New Findings on Nicotine Addiction and Treatment
Over the last 10 years, we have witnessed a rapid expansion in both the scientific understanding of tobacco addiction and in the range of pharmacotherapies available for smoking cessation treatment. These recent developments will be reviewed below, emphasizing the link between basic research and the development of new treatments. This link is bidirectional: increased knowledge gained from basic animal and human laboratory research informs the development of new treatments; in addition, however, findings from treatment studies help us test and refine hypotheses about underlying mechanisms. We will consider three main areas of treatment research: (1) pre-cessation administration of therapeutic agents, including nicotine, varenicline, mecamylamine and bupropion; (2) development of nicotine vaccines; and (3) progress towards tailoring cessation treatments based on a smoker’s genetic make-up.
Pre-cessation Administration of Pharmacologic Agents
Pre-cessation use of Nicotine...
KeywordsNicotine Replacement Therapy Nicotinic Receptor Rewarding Effect Nicotine Patch Smoking Cessation Treatment
This work was supported by an unrestricted grant on adult smoking cessation provided by Philip Morris USA, Inc. The author appreciates helpful suggestions on an earlier draft of this manuscript from Frederique Behm and Alexey Mukhin, M.D., Ph.D.
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