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Isotopic Steady-State Flux Analysis

  • Jörg Schwender
Chapter

Metabolic flux analysis (MFA) provides an integrated view of the function of biochemical pathways within a cell and is an important methodology in systems biology and metabolic engineering [102]. Originally developed to study microbial metabolism, it has also been applied to plants [67, 74, 83, 85, 88, 106]. A key concept in MFA is the biochemical reaction stoichiometry, which is used to mathematically describe a cellular reaction network at metabolic steady state. For example, the theoretical capability of metabolic network can be explored by exhaustive enumeration of all possible distinct routes in a metabolic network [96, 101; see also Chapter 8].

Keywords

Metabolic Network Fatty Acid Synthesis Flux Balance Analysis Flux Analysis Central Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Brookhaven National LaboratoryBiology DepartmentUptonUSA

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