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Role of VEGF in Organogenesis

  • Jody J. Haigh
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

The cardiovascular system, consisting of the heart, blood vessels and hematopoietic cells, is the first organ system to develop in vertebrates and is essential for providing oxygen and nutrients to the embryo and adult organs. Work done predominantly using the mouse and zebrafish as model systems has demonstrated that Vascular Endothelial Growth Factor (VEGF, also known as VEGFA) and its receptors KDR (FLK1/VEGFR2), FLT1 (VEGFR1), NRP1 and NRP2 play essential roles in many different aspects of cardiovascular development, including endothelial cell differentiation, migration and survival as well as heart formation and hematopoiesis. This review will summarize the approaches taken and conclusions reached in dissecting the role of VEGF signalling in vivo during the development of the early cardiovasculature and other organ systems. The VEGF-mediated assembly of a functional vasculature is also a prerequisite for the proper formation of other organs and for tissue homeostasis, because blood vessels deliver oxygen and nutrients and vascular endothelium provides inductive signals to other tissues. Particular emphasis will therefore be placed in this review on the cellular interactions between vascular endothelium and developing organ systems, in addition to a discussion of the role of VEGF in modulating the behavior of nonendothelial cell populations.

Keywords

Vascular Endothelial Growth Factor Amyotrophic Lateral Sclerosis Vascular Endothelial Growth Factor Gene Primitive Streak Endocardial Cushion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Jody J. Haigh
    • 1
  1. 1.Vascular Cell Biology Unit, Department for Molecular Biomedical Research (DMBR)Flanders Interuniversity Institute for Biotechnology (VIB)/Ghent UniversityGhent (Zwijnaarde)Belgium

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