Embryonic Vasculogenesis and Hematopoietic Specification

  • Lauren C. Goldie
  • Melissa K. Nix
  • Karen K. Hirschi
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Vasculogenesis is the process by which blood vessels are formed de novo. In mammals, vasculogenesis occurs in parallel with hematopoiesis, the formation of blood cells. Thus, it is debated whether vascular endothelial cells and blood cells are derived from a common progenitor. Whether or not this is the case, there certainly is commonality among regulatory factors that control the differentiation and differentiated function of both cell lineages. VEGF is a major regulator of both cell types and plays a critical role, in coordination with other signaling pathways and transcriptional regulators, in controlling the differentiation and behavior of endothelial and blood cells during early embryonic development, as further discussed herein.


Vascular Endothelial Growth Factor Endothelial Cell Proliferation Fluid Shear Stress Side Population Cell Primitive Streak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Lauren C. Goldie
    • 1
  • Melissa K. Nix
    • 2
  • Karen K. Hirschi
    • 2
    • 3
  1. 1.Department of Pediatrics, Children’ Nutrition Research Center and Center for Cell and Gene TherapyBaylor College of MedicineHoustonUSA
  2. 2.Department of Molecular and Cellular Biology Center for Cell and Gene TherapyBaylor College of MedicineHoustonUSA
  3. 3.Department of PediatricsChildren’s Nutrition Research CenterHoustonUSA

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