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Unexpected Reactions by In Vivo Applications of PEGylated Liposomes

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Book cover Safety of Nanoparticles

Part of the book series: Nanostructure Science and Technology ((NST))

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Abstract

PEGylated liposome, a liposome coated with polyethylene glycol (PEG), is understood to be biologically inert and, therefore, a suitable vehicle for in vivo applications. The most successful example is the doxorubicin-containing PEGylated liposome, known under the commercial name Doxil/Caelyx for cancer therapy. However, several researchers have found evidence that unexpected immune responses occur even to such polymer-coated liposomes after intravenous injection not only in animals but also in humans. An understanding of the immunological and pathological factors that control the pharmacokinetic and biological behavior of PEGylated liposomes is crucial for the design and safety of a system with optimal therapeutic and/or diagnostic performance. In this study, the interaction of PEGylated liposomes within the biological milieu following parenteral administration is discussed.

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Acknowledgments

We thank Dr. James L. McDonald for his helpful advice in writing the English manuscript.

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  1. Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, 1-78-1, Sho-machi, Tokushima, 770-8505, Japan

    Tatsuhiro Ishida & Hiroshi Kiwada

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  1. Tatsuhiro Ishida
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Correspondence to Hiroshi Kiwada .

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  1. School of Engineering, Brown University, 182 Hope Street, Providence, 02912, Rhode Island, USA

    Thomas J. Webster

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Ishida, T., Kiwada, H. (2009). Unexpected Reactions by In Vivo Applications of PEGylated Liposomes. In: Webster, T. (eds) Safety of Nanoparticles. Nanostructure Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78608-7_6

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