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Nanoparticles for Cancer Diagnosis and Therapy

  • Andrew Z. Wang
  • Frank X. Gu
  • Omid C. Farokhzad
Chapter
Part of the Nanostructure Science and Technology book series (NST)

Abstract

Nanotechnology enables unique approaches to the diagnosis and treatment of cancer. Over the last two decades, a large number of nanoparticle-based cancer diagnostics and therapeutics have been developed. These include superparamagnetic iron oxide nanoparticles, gold nanoparticles, liposomes and polymeric nanoparticles. While some of the liposomal and polymer-based therapeutic nanoparticles have advanced to clinical applications, a greater number of remaining nanoparticles platforms are currently in the preclinical stages of development. They have relatively incomplete toxicity profiles at this time. In this chapter, we will review the available preclinical and clinical toxicity data of a variety of nanoparticle platforms.

Keywords

Gold Nanoparticles Iron Oxide Nanoparticles Polymeric Micelle Liposomal Formulation Polymeric Nanoparticles 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank Drs. Philip Kantoff and Neil Bander for helpful discussions throughout this study. This work was supported by National Institutes of Health Grants CA119349 and EB003647 and Koch–Prostate Cancer Foundation Award in Nanotherapeutics.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Andrew Z. Wang
    • 1
  • Frank X. Gu
    • 2
    • 3
  • Omid C. Farokhzad
    • 4
    • 3
  1. 1.Laboratory of Nanomedicine and Biomaterials, Department of AnesthesiaBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Harvard-MIT Division of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA
  3. 3.MIT-Harvard Center for Cancer Nanotechnology ExcellenceMassachusetts Institute of TechnologyCambridgeUSA
  4. 4.Laboratory of Nanomedicine and Biomaterials, Department of AnesthesiaBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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