Functionally Defined T Cell Subsets in Transplantation Biology and Therapy: Regulatory T Cells and Th2 Cells

Part of the Cancer Treatment and Research book series (CTAR, volume 144)

Regulatory T Cells

Biology of CD4+CD25+ Regulatory T Cells (Treg Cells)

Peripheral tolerance mechanisms include deletion by activation induced cell death, anergy and dominant suppression. Although the important contribution of suppression for the maintenance of peripheral T-cell tolerance was repeatedly proven in experimental systems, it was discredited for many years as no defined suppressor cell population could be identified. In 1995, Sakaguchi and coworkers rejuvenated interest in T-cell-mediated immunosuppression when they showed that thymectomy in neonatal mice caused autoimmunity that could be prevented by adoptive transfer of CD25-coexpressing CD4+ T cells isolated from adult animals [1]. These findings advanced the field in several aspects: (1) For the first time, phenotypic markers (CD4+CD25+) identified a cell population endowed with potent suppressive activity; (2) the suppressive cell population seemed to be thymus-derived; (3) its export from the thymus seemed to be...


Hematopoietic Stem Cell Transplantation Treg Cell Acute GvHD Allogeneic Hematopoietic Stem Cell Transplantation Chronic GvHD 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Experimental Transplantation and Immunology BranchCenter for Cancer Research, National Cancer InstituteBethesdaUSA

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