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Cellular Adoptive Immunotherapy After Autologous and Allogeneic Hematopoietic Stem Cell Transplantation

  • David L. Porter
  • Elizabeth O. Hexner
  • Sarah Cooley
  • Jeffrey S. Miller
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 144)

Introduction

HSCT remains the best if not only curative therapy for many patients with hematologic malignancies. The success of HSCT is related not just to the high dose conditioning therapy, but at least in the setting of allogeneic HSCT, the donor graft itself can provide powerful “graft-versus-leukemia” (GvL) activity critically important for the cure of many patients. The relevant cellular immune components of the donor graft include at least T cells, natural killer (NK) cells and B cells, all recognized in various settings as potential effectors of the GvL (or graft-versus-tumor, GvT) effect. Although GvL activity was identified in some of the earliest murine models of HSCT [1], it took many years to unequivocally prove GvL activity was critical in clinical transplantation. Numerous observations implicated mature donor T cells as primarily mediators of GvL, and a tight association of GvL activity and graft-versus-host disease (GvHD) was repeatedly observed [2]. Ultimately, the...

Keywords

Natural Killer Cell Chronic Myelogenous Leukemia Acute Myelogenous Leukemia Mesenchymal Stromal Cell Acute GvHD 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported in part by grants from The Leukemia & Lymphoma Society (7000-02) and NIH (K24 CA11787901) (DLP) and P01 CA111412 and P01 CA65493 (JM).

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • David L. Porter
    • 1
  • Elizabeth O. Hexner
  • Sarah Cooley
  • Jeffrey S. Miller
  1. 1.Division of Hematology-OncologyUniversity of Pennsylvania Medical CenterPhiladelphiaUSA

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