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The Principles and Overview of Autologous Hematopoietic Stem Cell Transplantation

  • William Vaughan
  • Tara Seshadri
  • Mark Bridges
  • Armand Keating
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 144)

Introduction

Autologous hematopoietic stem cell transplantation (HSCT) refers to the use of self-renewing progenitor cells derived either from the patient’s own marrow or peripheral blood, as opposed to cells from an allogeneic or syngeneic donor, to repopulate the hematopoietic system after administration of chemotherapy. This treatment modality enables very high (“myeloablative”) doses of chemotherapy to be administered in the hope of eradicating tumors while avoiding the serious side effect of prolonged myelosuppression or even marrow ablation. Autologous HSCT is best viewed as one step in the treatment strategy for malignant (usually hematological) diseases and not a therapeutic entity in itself.

Almost half a century has passed since the first report of the infusion of autologous bone marrow into a human to facilitate hematopoietic reconstitution following high-dose chemotherapy [1], although interest in the therapeutic use of marrow dates back much further. Brown-Sequard and...

Keywords

Overall Survival Multiple Myeloma Acute Myeloid Leukemia Hematopoietic Stem Cell Transplantation Minimal Residual Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • William Vaughan
    • 1
  • Tara Seshadri
  • Mark Bridges
  • Armand Keating
  1. 1.University of Alabama Bone Marrow Transplantation Program, University of Alabama Comprehensive Cancer CenterBirminghamUSA

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