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Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia

  • Daniel Weisdorf
  • Stephen Forman
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 144)

Introduction

Although multidrug chemotherapy yields complete remission (CR) for nearly 90% of adults with acute lymphoblastic leukemia (ALL, a.k.a. acute lymphocytic leukemia), post-remission therapy fails to control disease recurrence for the majority [1, 2, 3, 4, 5, 6, 7, 8]. Twenty percent of adult acute leukemia is ALL, and despite some parallels to the morphology and molecular features of pediatric ALL, where therapy is often curative [9, 10, 11, 12], the majority of adults have high-risk phenotypes of disease, and current therapies remain inadequate. Extended leukemia-free survival (LFS) in unlikely, particularly for those with high-risk features including age greater than 35 years, elevated white blood count (WBC) at diagnosis, cytogenetically high-risk subsets and poor initial response to therapy. These further truncate the odds of extended LFS. Newer immunopathologic, molecular and monitoring techniques have improved classifications and potentially allowed risk-directed...

Keywords

Acute Lymphoblastic Leukemia Hematopoietic Stem Cell Transplantation Minimal Residual Disease Total Body Irradiation Allogeneic Hematopoietic Stem Cell Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.University of Minnesota, Mayo Mail Code 480MinneapolisUSA

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