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Biology and Management of Acute Graft-Versus-Host Disease

  • Robert Korngold
  • Joseph H. Antin
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 144)

Introduction

Extensive investigations over the last 25 years of the basic biology of acute graft-versus-host disease (GvHD) in murine models of allogeneic blood and marrow transplantation (BMT), particularly in major histocompatibility complex (MHC)-matched, minor histocompatibility antigen (miHA) different strain combinations, has brought us to an understanding of much of the etiology and pathogenesis of this disease. The relative contributions of mature donor CD4+ and CD8+T cells in causing the development of GvHD across different histocompatibility barriers has been clarified and the involvement of host conditioning factors and the requirements for inflammatory cytokines at early stages after transplant are now appreciated. We also now have a reasonable understanding of what miHA are and how T cells recognize them, although which particular minor H antigens elicit severe GvHD responses in mice is still far from clear. Overall, the elucidation of the complex aspects of GvHD...

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Class Conditioning Regimen Acute GvHD Chronic GvHD 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Dana-Farber Cancer InstituteBostonUSA

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