Topical Treatment of Field Cancerization
The concept of “field cancerization” was established by Slaughter  in 1953 to describe the presence of histologically abnormal tissue surrounding an invasive squamous cell carcinoma from the upper gastrointestinal tract. The term was proposed to explain the development of multiple primary tumours and locally recurrent cancer; this specifically accounts for organ systems such as the skin (head and neck) cancers, in the ENT areas (oral cavity, oropharynx, and larynx), but also the lung, vulva, esophagus, cervix, breast, skin, colon, and bladder.
KeywordsTransplant Recipient Actinic Keratose Organ Transplant Recipient Invasive Squamous Cell Carcinoma Imiquimod Cream
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