Merkel Cell Carcinoma

  • Jean Kanitakis
Part of the Cancer Treatment and Research book series (CTAR, volume 146)

Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer, first described by Toker in 1972 as “trabecular carcinoma of the skin” [1]. It is also known as primary neuroendocrine skin carcinoma, Toker tumor, cutaneous apudoma, or Merkel cell tumor. The origin of this malignancy from epidermal Merkel cells is likely but not unequivocally proven, and therefore the term primary neuroendocrine skin carcinoma seems more appropriate; however, the term Merkel cell carcinoma has prevailed in the literature and is adopted here. To date, several hundreds of MCC cases have been reported. An important percentage of these develop in immunocompromised patients, including solid organ transplant recipients (OTR). The salient features of MCC, with emphasis on those cases appearing in the setting of organ transplantation, are reviewed here.


Sentinel Lymph Node Biopsy Skin Cancer Merkel Cell Carcinoma Organ Transplant Recipient Solid Organ Transplant Recipient 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Jean Kanitakis
    • 1
  1. 1.Department of DermatologyEdouard Herriot HospitalFrance

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