Skip to main content
SpringerLink
Log in

Kaposi’s Sarcoma

  • Chapter
Book cover Skin Cancer after Organ Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 146))

Herpesviruses are double-stranded DNA viruses that can remain latent in vertebrate hosts. Eight human herpesviruses have been discovered to date. Herpesviruses are classified into three subfamilies, a, ß, and ? , on the basis of their genome structure and biological properties. Kaposi’s sarcoma-associated virus (KSHV), also known as human herpesvirus 8 (HHV8), is a gamma herpesvirus (rhadinovirus) closely related to Epstein–Barr virus (EBV) and in the lineage of various rhadinoviruses infecting macaques, African green monkeys (Fig. 1). It was discovered in 1994 by Chang et al. [1] in a Kaposi’s sarcoma (KS) specimen from an human immunodeficiency virus (HIV)-infected patient using representational difference analysis and was shown to be the long-sought infectious agent responsible for KS. Since then, its association has been confirmed in all clinical settings of KS and was extended to a limited number of lymphoproliferations including multicentric Castleman’s disease and primary effusion lymphoma (PEL) [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 266:1865–9.

    Article  PubMed  CAS  Google Scholar 

  2. Farge D, and the collaborative transplantation research group of Ile de France. Kaposi’s sarcoma in organ transplant recipients. Eur J Med 1993; 2:339–43.

    Google Scholar 

  3. Garcia-Astudillo L, Leyva-Cobian F. Human herpes-virus-8 infection and Kaposi’s sarcoma after liver and kidney transplantation in different geographical areas of Spain. Transplant Immunol 2006; 17:65–9.

    Article  CAS  Google Scholar 

  4. Serraino D, Angeletti C, Carrieri MP, Longo B, Piche M, Piselli P, Piselli P, Arbustini E et al. Kaposi’s sarcoma in transplant and HIV-infected patients: an epidemiologic study in Italy and France. Transplantation 2005; 80:1699–704.

    Article  PubMed  Google Scholar 

  5. Serraino D, Piselli P, Angeletti C, Minetti E, Pozzetto A, Civati G, Brelleli S et al. Risk of Kaposi’s sarcoma and other cancers in Italian renal transplant patients. Br J Cancer 2005; 92:572–5.

    PubMed  CAS  Google Scholar 

  6. Qunibi WY, Barri Y, Aifurayh O, Almeshari K, Khan B, Taher S, Sheth K. Kaposi’s sarcoma in renal transplant recipients: a report on 26 cases from a single institution. Transplant Proc 1993; 25:1402–5.

    PubMed  CAS  Google Scholar 

  7. Margolius L, Stein M, Spencer D, Bezwoda WR. Kaposi’s sarcoma in renal transplant recipients. Experience at Johannesburg Hospital, 1966–1989. S Afr Med J 1994; 84:16–7.

    CAS  Google Scholar 

  8. Shmueli D, Shapira Z, Yussim A, Nakache R, Ram Z, Shaharabani E. The incidence of Kaposi’s sarcoma in renal transplant patients and its relation to immunosuppression. Transplant Proc 1989; 21:3209–10.

    PubMed  CAS  Google Scholar 

  9. Zahger D, Lotan C, Admond D, Klapholz L, Kaufman B, Shimon D, Woolfson N, Gotsman MS. Very early appearance of Kaposi’s sarcoma after cardiac transplantation in Sephardic Jews. Am Heart J 1993; 126:999–1000.

    Article  PubMed  CAS  Google Scholar 

  10. Mbulaitey SM, Engels EA. Kaposis’s sarcoma risk among transplant recipients in the United States (1993–2003). Int J Cancer 2006; 119:2685–91.

    Article  CAS  Google Scholar 

  11. Frezza EE, Fung JJ, van Thiel DH. Non-lymphoid cancer after liver transplantation. Hepatogastroenterology 1997; 44:1172–81.

    PubMed  CAS  Google Scholar 

  12. Shepherd FA, Maher E, Cardella C, Cole E, Greig P, Wade JA, Levy G. Treatment of Kaposi sarcoma after solid organ transplantation. J Clin Oncol 1997; 15:2371–7.

    PubMed  CAS  Google Scholar 

  13. Penn I. Sarcomas in organ allografts recipients. Transplantation 1995; 60:1485–91.

    Article  PubMed  CAS  Google Scholar 

  14. Harwood AR, Osoba D, Hofstader SL, Goldstein MB, Cardella CJ, Holecek MJ, Kunynetz R, Giammarco RA. Kaposi’s sarcoma in recipients of renal transplants. Am J Med 1979; 67:759–65.

    Article  PubMed  CAS  Google Scholar 

  15. Euvrard S, Kanitakis J, Claudy A. Skin cancers after organ transplantation. N Engl J Med 2003; 348:1681–91.

    Article  PubMed  Google Scholar 

  16. Woodle E, Hanaway M, Buell J, Gross T, First MR, Trofe J, Beebe T; Israel Penn International Transplant Tumor Registry. Kaposi’s sarcoma: an analysis of the US and international experiences from the Israel Penn International Transplant Tumor Registry. Transplant Proc 2001; 33:3660–1.

    Article  PubMed  CAS  Google Scholar 

  17. Marcelin AG, Calvez V, Dussaix E. KSHV after an organ transplant: should we screen? Curr Top Microbiol Immunol 2007; 312:245–62.

    Article  PubMed  CAS  Google Scholar 

  18. Cattani P, Capuano M, Graffeo R, Ricci R, Cerimele F, Cerimele D, Nanni G, Fadda G. Kaposi’s sarcoma associated with previous human herpesvirus 8 infection in kidney. J Clin Microbiol 2001; 39:506–8.

    Article  PubMed  CAS  Google Scholar 

  19. Francès C, Mouquet C, Marcelin AG, Barete S, Agher R, Charron D, Benalia H et al. Outcome of kidney transplant recipients with previous human herpesvirus-8 infection. Transplantation 2000; 69:1776–9.

    Article  PubMed  Google Scholar 

  20. Andreoni M, Goletti D, Pezzotti P, Monini P, Sarmati L, Farchi T et al. Prevalence, incidence and correlates of HHV-8/KSHV infection and Kaposi’s sarcoma in renal and liver transplant recipients. J Infect 2001; 43:195–9.

    Article  PubMed  CAS  Google Scholar 

  21. Marcelin AG, Roque-Afonso AM, Hurtova M, Dupin N, Tulliez M, Sebagh M, Arkoub ZA et al. Fatal disseminated Kaposi’s sarcoma following human herpesvirus 8 primary infections in liver-transplant recipients. Liver Transplant 2004; 10:295–300.

    Article  Google Scholar 

  22. Aseni P, Vertemati M, Minola E, Arcieri K, Bonacina E, Camozzi M, Osio C et al. Kaposi’s sarcoma in liver transplant recipients: morphological and clinical description. Liver Transplant 2001; 7:816–23.

    Article  CAS  Google Scholar 

  23. Edmond JP, Marcellin AG, Dorent R, Milliancourt C, Dupin N, Frances C, Agut H, Gandjbakhch I, Calvez V. Kaposi’s sarcoma associated with previous human herpesvirus 8 infection in heart transplant recipients. J Clin Microbiol 2002; 40:2217–9.

    Article  Google Scholar 

  24. Sachsenberg-Studer EM, Dobrynski N, Sheldon J, Schulz TF, Pechere M, Nadore RG, Spiliopoulos A et al. Human herpes-virus 8 seropositive patient with skin and graft Kaposi’s sarcoma after lung transplantation. J Am Acad Dermatol 1999; 40:308–11.

    Article  PubMed  CAS  Google Scholar 

  25. Barozzi P, Luppi M, Facchetti F, Mecucci G, Alu M, Sarid R, Rasini V et al. Post-transplant Kaposi’s sarcoma originates from the seeding of donor-derived progenitors. Nat Med 2003; 9:554–61.

    Article  PubMed  CAS  Google Scholar 

  26. Marcelin AG, Roque-Afonso AM, Hurtova M, Dupin N, Tulliez M, Sebagh M, Arkoub ZA, et al. Fatal disseminated Kaposi’s sarcoma following human herpesvirus 8 primary infections in liver-transplant recipients. Liver Transplant 2004; 10:295–300.

    Article  Google Scholar 

  27. Regamey N, Tamm M, Wernli M, Witschi A, Thiel G, Cathomas G, Erb P. Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. N Engl J Med 1998; 339:1358–63.

    Article  PubMed  CAS  Google Scholar 

  28. Milliancourt C, Barete S, Marcelin AG, Mouquet C, Dupin N, Frances C, Agut H, Bitker MO, Calvez V. Human herpes-virus-8 seroconversions after renal transplantation. Transplantation 2001; 72:1319–20.

    Article  PubMed  CAS  Google Scholar 

  29. Micali G, Gasparri O, Nasca MR, Sapuppo A. Kaposi’s sarcoma occurring de novo in the surgical scar in a heart transplant recipient. J Am Acad Dermatol 1992; 27:273–4.

    Article  PubMed  CAS  Google Scholar 

  30. Barete S, Calvez V, Mouquet C, Barrou B, Kreis H, Dantal J, Dorent R, Durand F, Dimitrov Y, Dupin N, Marcelin AG, Piette JC, Bitker MO, Frances C. Kaposi’s sarcoma in organ allograft recipients: clinical features and contribution of virological findings for the management of the disease. Arch Dermatol 2000; 136:1452–6.

    Article  PubMed  CAS  Google Scholar 

  31. Quniby WY, Akhtar M, Ginn E, Smith P. Kaposi sarcoma in cyclosporin-induced gingival hyperplasia. Am J Kidney Dis 1988; 11:349–2.

    Google Scholar 

  32. Lopes P, Petit T, Audoin AF, Lenne Y. Sarcome de Kaposi du col utérin chez une transplantée cardiaque (lettre). Presse Med 1988; 17:1539.

    PubMed  CAS  Google Scholar 

  33. Frances C. Kaposi’s sarcoma after renal transplantation. Nephrol Dial Transplant 1998; 13:2368–73.

    Article  Google Scholar 

  34. Restrepo CS, Martinez S, Lemos JO, Carrillo JA, Lemos DF, Ojeda P, Koshy P. Imaging manifestations of Kaposi’s sarcoma. Radiographics 2006; 26:1169–85.

    Article  PubMed  Google Scholar 

  35. Dupin N, Fisher C, Kellam P, Ariad S, Tulliez M, Franck N, et al. Distribution of human herpesvirus-8 latently infected cells in Kaposi’s sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Proc Natl Acad Sci U S A 1999; 96:4546–51.

    Article  PubMed  CAS  Google Scholar 

  36. Gill PS, Tsai YC, Rao AP, Spruck CH 3rd, Zheng T, Harrington WA, Cheung T Jr, Nathwani B, Jones PA. Evidence for multiclonality in multicentric Kaposi’s sarcoma. Proc Natl Acad Sci USA 1998; 95:8257–61.

    Article  PubMed  CAS  Google Scholar 

  37. Klass CM, Offerman MK. Targeting human herpesvirus-8 for treatment of Kaposi’s sarcoma and primary effusion lymphoma. Curr Opin Oncol 2005; 17:447–55.

    Article  PubMed  CAS  Google Scholar 

  38. Pellet C, Chevret S, Francès C, Euvrard S, Hurault M, Legendre C, Dalac S, et al. Prognostic value of quantitative Kaposi sarcoma-associated herpes virus load in posttransplantation Kaposi sarcoma. J Infect Dis 2002; 186:110–3.

    Article  PubMed  Google Scholar 

  39. Al-Khader AA, Suleiman M, Al-Hasani M, Haleem A. Posttransplant Kaposi’s sarcoma: staging as a guide to therapy and prognosis. Nephron 1988; 48:165.

    Article  PubMed  CAS  Google Scholar 

  40. Stallone G, Schena A, Infante B, Di Paolo S, Loverre A, Maggio G, Ranieri E, et al. Sirolimus for Kaposi’s sarcoma in renal-transplant recipients. N Engl J Med 2005; 352:1317–23.

    Article  PubMed  CAS  Google Scholar 

  41. Campistol JM, Gutierrez-Dalmau A, Torregrosa JV. Conversion to sirolimus: a successful treatment for posttransplantation Kaposi’s sarcoma. Tranplantation 2004; 77:760–2.

    Article  Google Scholar 

  42. Gutierrez-Dalmau A, Sanchez-Fructuoso A, Sanz-Guajardo A, Mazuecos A, Franco A, Rial MC, Iranzo P. Efficacy of conversion to sirolimus in posttransplantation Kaposi’s sarcoma. Tranplant Proc 2005; 37:3836–8.

    Article  CAS  Google Scholar 

  43. Boeckle E, Boesmueller C, Wiesmayr S, Mark W, Rieger M, Tabarelli D, Graziadei I, et al. Kaposi’s sarcoma in solid organ transplant recipients: a single center report. Transplant Proc 2005; 37:1905–9.

    Article  PubMed  CAS  Google Scholar 

  44. Zmonarski SC, Boratynska M, Rabczynski J, Kazimierczak K, Klinger M. Regression of Kaposi’s sarcoma in renal graft recipients after conversion to sirolimus treatment. Transplant Proc 2005; 37:964–6.

    Article  PubMed  CAS  Google Scholar 

  45. Mohsin N, Budruddin M, Pakkyara A, Darweesh A, Nayyer M, Amitabh J, Daar AS. Complete regression of visceral Kaposi’s sarcoma after conversion to sirolimus. Exp Clin Transplant 2005; 3:366–9.

    PubMed  CAS  Google Scholar 

  46. Lebbe C, Euvrard S, Barrou B, Pouteil-Noble C, Garnier JL, Glotz D, Legendre C, Frances C. Sirolimus conversion for patients with posttransplant Kaposi’s sarcoma. Am J Transplant 2006; 6:2164–8.

    Article  PubMed  CAS  Google Scholar 

  47. Campistol JM, Schena FP. Kaposi’s sarcoma in renal transplant recipients: the impact of proliferation signal inhibitors. Nephrol Dial Transplant 2007; 22(suppl 1): i17–i22.

    Article  PubMed  CAS  Google Scholar 

  48. Boratynska M, Zmonarski SC, Klinger M. Recurrence of Kaposi’s sarcoma after increased exposure to sirolimus. Int Immunopharmacol 2006; 6:2018–22.

    Article  PubMed  CAS  Google Scholar 

  49. Wasywich CA, Croxson MC, van Doornum GJ, Coverdale HA, Ruygrok PN. Sirolimus for Kaposi’s sarcoma. J Heart Lung Transplant 2006; 25:726–9.

    Article  PubMed  Google Scholar 

  50. Descoeudres B, Giannini O, Graf T, Steiger J, Mayr M. No effect of sirolimus for Kaposi sarcoma in a renal transplant recipient. Transplantation 2006; 81:1472–4.

    Article  PubMed  Google Scholar 

  51. Di Paolo S, Teutonico A, Ranieri E, Gesualdo L, Schena PF. Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma. Am J Kidney Dis 2007; 49:462–70.

    Article  PubMed  CAS  Google Scholar 

  52. Magnone M, Holley J, Shapiro R, Scantelbury V, McCauley J, Jordan M, Vivas C, Starzl T, Johnson J. Interferon-α induced acute renal allograft rejection. Transplantation 1994; 59:1068–70.

    Article  Google Scholar 

  53. Wright WHL, Galaver JS, Van Thiel DH. Preliminary experience with alpha-2b-interferon therapy of viral hepatitis in liver allograft recipients. Transplantation 1994; 53:121–4.

    Article  Google Scholar 

  54. Halmos O, Inturri P, Galligioni A, Di Landro D, Rigotti P, Tedeschi U, Graziotto A, Burra P, Poletti A, Rossaro L. Two cases of Kaposi’s sarcoma in renal and liver transplant recipients treated with interferon. Clin Transplant 1996; 10: 374–8.

    PubMed  CAS  Google Scholar 

  55. Euvrard S, Kanitakis J, Bosshard S, Lebbe C, Garnier JL, Touraine JL, Claudy A. No recurrence of posttransplantation Kaposi’s sarcoma three years after renal retransplantation. Transplantation 2002; 73:297–9.

    Article  PubMed  Google Scholar 

  56. Segoloni GP, Giraudi R, Messina M, Rossetti M, Biancone L, Leonardi G, Piccoli GB, Magnano A, Gai M. No recurrence of Kaposi’s sarcoma in a case of renal retransplantation under a calcineurin inhibitor free immunosuppressive regimen: first report. Transplant Int 2007; 20:395–6.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, APHP Hospital Tenon Paris, Paris, France

    Camille Francøs

  2. Department of Dermatology, APHP Hospital Saint Louis, Paris Inserm U 716, France

    Cùleste Lebbù

Authors
  1. Camille Francøs
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cùleste Lebbù
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik für Dermatologie Venerologie und Allergologie, Charité - Universitätsklinikum Berlin Charite Campus Mitte Klinik und Poliklinik for Dermatologie, Charitéplatz 1, 10117 Berlin, Germany

    Eggert Stockfleth MD, PhD  & Claas Ulrich  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Francøs, C., Lebbù, C. (2009). Kaposi’s Sarcoma. In: Stockfleth, E., Ulrich, C. (eds) Skin Cancer after Organ Transplantation. Cancer Treatment and Research, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78574-5_24

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-78574-5_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-78573-8

  • Online ISBN: 978-0-387-78574-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation