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Molecular Pathogenesis of Squamous Cell Carcinoma

  • Ingo Nindl
  • Frank Rösl
Part of the Cancer Treatment and Research book series (CTAR, volume 146)

Nonmelanoma skin cancer (NMSC), comprising basal cell carcinoma (BCC), Bowen’s disease, cutaneous squamous cell carcinoma (SCC), and its early-stage actinic keratosis (AK), is the most frequent malignancy among populations of European origin [1,2]. Cutaneous SCC accounts for 10% to 20% of all skin malignancies and is the second most common skin cancer after BCC. Epidermal keratinocytes from the suprabasal layer are the origin of this cancer. The major risk factor is ultraviolet radiation (UV), and multiple factors result in the development of this disease. SCC are invasive tumours whose cells histologically appear like differentiated suprabasal keratinocytes, and approximately 3% metastasise. It grows faster than BCC and produces a more indurated, hyperkeratotic lesion with ulceration. Cutaneous SCC frequently occurs as multiple primary tumours in the same skin area (“field”) in proximity to each other and is termed field cancerisation [3].

Keywords

Squamous Cell Carcinoma Skin Cancer Basal Cell Carcinoma Actinic Keratosis Cutaneous Squamous Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ingo Nindl
    • 1
  • Frank Rösl
    • 2
  1. 1.Charité Cooperation, Viral Skin Carcinogenesis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 24269120 HeidelbergGermany
  2. 2.Division Viral Transformation MechanismGerman Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 HeidelbergGermany

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