Molecular Events in Skin Cancer

  • Thomas Meyer
Part of the Cancer Treatment and Research book series (CTAR, volume 146)

Skin cancer represents the most frequent cancer in humans and includes different entities, based on the cell types and tissues affected. Next to epithelial tumors, such as keratinocyte-derived basal cell carcinomas (BCC) and squamous cell carcinomas (SCC), and neuroendocrine Merkel cell carcinoma (MCC), skin malignancies also include neuroectodermal malignant melanoma (MM), as well as tumors of skin-associated tissues, lipomas, angiosarcomas, tumors of connective tissue, and cutaneous lymphomas. Ultraviolet (UV) radiation is an important risk factor for epithelial tumors and MM, because most of the tumor lesions occur in sun-exposed skin areas and contain UV signature mutations [1, 2]. However, some tumors are located in sun-protected body areas, indicating other factors involved in carcinogenesis.


Malignant Melanoma Skin Cancer Basal Cell Carcinoma HaCaT Cell Merkel Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Thomas Meyer
    • 1
  1. 1.Institute of Medical Microbiology Virology and Hygiene, University Hospital Hamburg-Eppendorf, University of Hamburg, Martinistrasse 52HamburgGermany

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