Interaction Between Ultraviolet Radiation and Human Papillomavirus

  • Alan Storey
  • Mark Simmonds
Part of the Cancer Treatment and Research book series (CTAR, volume 146)

Human papillomaviruses (HPV) are small double-stranded DNA viruses that predominantly form hyperproliferative lesions in mucosal and cutaneous epithelial tissues and are strictly epitheliotropic. More than 120 different types have been characterised based on DNA sequence homology [1]. The association between HPV and cervical cancer has been well documented,with 99% of cervical tumours containing HPV DNA [2]. The expression of E6 and E7 proteins of high-risk anogenital types, such as HPV 16 and 18, has been linked with the subsequent degradation of both p53 and pRb, respectively, and the constitutive expression of both viral proteins in anogenital tumours is required to maintain this transformed state [3].


Basal Cell Carcinoma Organotypic Culture Skin Tumour Primary Human Keratinocytes Squamous Cell Dysplasia 


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Alan Storey
    • 1
  • Mark Simmonds
    • 2
  1. 1.Molecular Oncology Department, Weatherall Institute for Molecular MedicineJohn Radcliffe Hospital, University of OxfordOxfordUnited Kingdom
  2. 2.Cancer Research UK Skin Tumour Laboratory Institute of Cell and Molecular ScienceUnited Kingdom

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