The Marmoset Brain in Stereotaxic Coordinates
The marmoset (Callithrix jacchus) is a New World primate that is used in toxicology as a non-rodent species and more broadly, in the field of neurosciences. Among non-human primates, the marmoset represents a species of choice given its small size (14–18 cm, 400 g), biosafety, ease of handling and ethical considerations. It also allows for reducing the use of Macaques that fall under the Washington declaration. When pharmaceutical bulk is the limiting factor, the marmoset enables to progress a project rapidly to clinical phase and there is now a broad industry history of use and regulatory acceptance. It also appears to be a valuable animal model to study central nervous system (CNS) neurodegenerative diseases.
Due to little published data in this species, generating robust historical database and references is a challenge for scientists to establish leadership in the use of this model in preclinical or mechanistic studies (Saavedra, 1968; Stephan, 1980; Eidelberg, 1960)....
KeywordsInferior Colliculus Thalamic Nucleus Cerebellar Nucleus Amygdaloid Nucleus Ventral Cochlear Nucleus
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