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Gene Therapy for Chronic Pain

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Biobehavioral Approaches to Pain

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Abstract

Gene therapy shows great potential to assist numerous patients with inadequate relief of inflammatory or neuropathic pain, or intractable pain associated with advanced cancer. A brief overview is provided of the methods of gene therapy and of preclinical findings in animal models of prolonged inflammatory, neuropathic and cancer pain. Preclinical findings demonstrate no efficacy of gene therapy on basal thermal nociception and mechanical sensitivity, and almost universal effects on pathological nociception and hypersensitivity models. The status of human trials is provided with recommendations for future directions and precautions. This early stage of development of gene therapy for chronic pain will likely be followed by an increased number of human clinical trials aimed specifically at the relief of chronic, unrelenting pain.

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  1. Assistant Professor, Department of Anesthesiology, University of Pittsburgh School of Medicine, A-1305 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA

    William R. Lariviere

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  1. William R. Lariviere
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  2. Doris K. Cope
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Correspondence to William R. Lariviere .

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Lariviere, W.R., Cope, D.K. (2009). Gene Therapy for Chronic Pain. In: Biobehavioral Approaches to Pain. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78323-9_19

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  • DOI: https://doi.org/10.1007/978-0-387-78323-9_19

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