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Impact of Medication Delivery Method on Patient Adherence

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Asthma, Health and Society

Abstract

In this chapter, we provide a systematic review of randomized controlled trials, meta-analysis, case-control, or cohort studies that compared patient adherence with, or preference for, oral or inhaled controller medication for asthma. Among 17 studies meeting inclusion criteria for our review, patients were more adherent to oral than inhaled medications. Where queried, patients or parents expressed preference for oral medications. These findings were consistent across study designs, using contrasting measures of adherence, over varied time periods and including many with 12-month follow-up, and with patients who knew they were being monitored as well as those included in an anonymous database. Indirect evidence indicates that patient’s preference for oral medication is not related to dosing frequency.

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References

  • Adherence to Long-Term Therapies: Evidence for Action. World Health Organization, 2003

    Google Scholar 

  • Adams RJ, Fuhlbrigge A, Guilbert T, Lozano P, Martinez F (2002) Inadequate use of asthma mediation in the United States: results of the asthma in America national population survey. J Allergy Clin Immunol 110:58–64

    Article  PubMed  Google Scholar 

  • Alessandro G, Vincenzo Z, Marco S, Marcello G, Enrica R (1994) Compliance with pharmacologic prophylaxis and therapy in bronchial asthma. Ann Allergy 73:135–140

    CAS  PubMed  Google Scholar 

  • Apter A, Reisine S, Affleck G, Barrows E, ZuWallack R (1998) Adherence with twice-daily dosing of inhaled steroids. Am J Respir Crit Care Med 157:1810–1817

    CAS  PubMed  Google Scholar 

  • Apter A, Boston R, George M et al (2003) Modifiable barriers to adherence to inhaled steroids among adults with asthma: it’s not just black and white. J Allergy Clin Immunol 111:1219–1226

    Article  PubMed  Google Scholar 

  • Balkrishnan R, Nelsen LM, Kulkarni AS, Pleasants RA, Whitmire JT, Schechter MS (2005) Outcomes associated with initiation of different controller therapies in a Medicaid asthmatic population: a retrospective data analysis. J Asthma 42(1):35–40

    Article  PubMed  Google Scholar 

  • Barr R, Somers S, Speizer F, Camargo CJ (2002) Patient factors and medication guideline adherence among older women with asthma. Arch Intern Med 162:1761–1768

    Article  PubMed  Google Scholar 

  • Bateman ED, Boushey HA, Bousquet J et al (2004) Can guideline-defined asthma control be achieved? The gaining optimal asthma control study. Am J Respir Crit Care Med 170:836–844

    Article  PubMed  Google Scholar 

  • Beardon PH (1993) Primary non-compliance with prescribed medication in primary care. Br Med J 307:846–848

    Article  CAS  Google Scholar 

  • Bender BG, Bender SE (2005) Patient-identified barriers to asthma treatment adherence: responses to interview, focus groups, and questionnaires. Immunol Allergy Clin North Am 25:107–130

    Article  PubMed  Google Scholar 

  • Bender B, Wamboldt F, O’Connor S et al (2000) Measurement of children’s asthma medication adherence by self report, mother report, canister weight, and Doser CT. Ann Allergy Asthma Immunol 85:416–421

    Article  CAS  PubMed  Google Scholar 

  • Bosley CM, Parry DT, Cochrane GM (1994) Patient compliance with inhaled medication: does combining beta-agonists with corticosteroids improve compliance? Eur Respir J 7(3):504–509

    Article  CAS  PubMed  Google Scholar 

  • Bukstein D, Luskin AT, Bernstein BA (2003a) “Real-world” effectiveness of daily controller medicine in children with mild persistent asthma. Ann Allergy Asthma Immunol 90:543–549

    Article  PubMed  Google Scholar 

  • Bukstein DA, Bratton DL, Firriolo KM et al (2003b) Evaluation of parental preference for the treatment of asthmatic children aged 6 to 11 years with oral montelukast or inhaled cromolyn: a randomized, open-label, crossover study. J Asthma 40(5):475–485

    Article  CAS  PubMed  Google Scholar 

  • Carter ER, Ananthakrishnan M (2003) Adherence to montelukast versus inhaled corticosteriods in children with asthma. Pediatr Pulmonol 36:301–304

    Article  PubMed  Google Scholar 

  • Cerveri I, Locatelli F, Zoia MC, Corsico A, Accordini S (1999) International variations in asthma treatment compliance: the results of the European Community Respiratory Health Survey (ECRHS). Eur Respir J 14:288–294

    Article  CAS  PubMed  Google Scholar 

  • Cooper WO, Hickson GB (2001) Corticosteroid presciption filling for children covered by Medicaid following an emergency department visit or a hospitalization for asthma. Arch Pediatr Adolesc Med 155:1111–1115

    CAS  PubMed  Google Scholar 

  • Coutts JA, Gibson NA, Paton JY (1992) Measuring compliance with inhaled medication in asthma. Arch Dis Child 67:332–333

    Article  CAS  PubMed  Google Scholar 

  • Cramer J, Mattson R, Prevey M, Scheyer R, Oullette V (1989) How often is medication taken as prescribed? A novel assessment technique. JAMA 261:3273–3277

    Article  CAS  PubMed  Google Scholar 

  • Creer G, Bender G (1993) Psychophysiological Disorders Research and Clinical Applications. In: Gotchel R, Blanchard E (eds) Asthma. American Psychological Association, Washington, DC, pp 151–208

    Google Scholar 

  • DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW (2002) Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 40:794–811

    Article  PubMed  Google Scholar 

  • Donahue JG, Weiss ST, Livingston JM, Goetsch MA, Greineder DK, Platt R (1997) Inhaled steroids and the risk of hospitalization for asthma. JAMA 277:887–891

    Article  CAS  PubMed  Google Scholar 

  • Dorais M, Glais L, Chabot I, LeLorier J (2005) Treatment persistence with leukotriene receptor antagonists and inhaled corticosteriods. J Asthma 42:385–393

    CAS  PubMed  Google Scholar 

  • Gibson N, Ferguson A, Aitchison T, Paton J (1995) Compliance with inhaled asthma medication in preschool children. Thorax 50:1274–1279

    Article  CAS  PubMed  Google Scholar 

  • Greenberg RN (1984) Overview of patient compliance with medication dosing: a literature review. Clin Ther 6(5):592–598

    CAS  PubMed  Google Scholar 

  • Harbour R, Miller JA (2001) A new system for grading recommendations in evidence based guidelines. BMJ 323:334–336

    Article  CAS  PubMed  Google Scholar 

  • Horne R, Weinman J (1999) Patients’ beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res 47(6):555–567

    Article  CAS  PubMed  Google Scholar 

  • Jones C, Santanello NC, Boccuzzi SJ, Wogen J, Strub P, Nelsen LM (2003) Adherence to prescribed treatment for asthma: evidence from pharmacy benefits data. J Asthma 40(1):93–101

    Article  PubMed  Google Scholar 

  • Kelloway JS, Wyatt RA, Adlis SA (1994) Comparison of patients’ compliance with prescribed oral and inhaled asthma medications. Arch Intern Med 154:1349–1352

    Article  CAS  PubMed  Google Scholar 

  • Krishnan JA, Riekert KA, McCoy JV et al (2004) Corticosteriod use after hospital discharge among high-risk adults with asthma. Am J Respir and Crit Care Med 170:1281–1285

    Article  Google Scholar 

  • Lai CK, DeGuia TS, Kim YY, Asthma insights and reality in Asia-Pacific Steering Committee et al (2003) Asthma control in the Asia-Pacific region: the asthma insights and reality in Asia-Pacific Study. J Allergy Clin Immunol 111:263–268

    Article  PubMed  Google Scholar 

  • Malo JL, Cartier A, Ghezzo H, Trudeau C, Morris J, Jennings B (1995) Comparison of four-times-a-day and twice-a-day dosing regimens in subjects requiring 1200 ug or less of budesonide to control mild to moderate asthma. Respir Med 89:537–543

    Article  CAS  PubMed  Google Scholar 

  • Mann M, Eliasson O, Patel K, ZuWallack L (1992) A comparison of the effects of bid and qid dosing on compliance with inhaled flunisolide. Chest 101(2):496–499

    Article  CAS  PubMed  Google Scholar 

  • Masoli M, Weatherall M, Holt S, Beasley R (2004) Systematic review of the dose-response relation of inhaled fluticasone propionate. Arch Dis Child 89:902–907

    Article  CAS  PubMed  Google Scholar 

  • Maspero JF, Duenas-Meza E, Volovitz B et al (2001) Oral montelukast versus inhaled beclomethasone in 6 to 11 year old children with asthma: results of an open-label extension study evaluating long-term safety satisfaction, and adherence with therapy. Curr Med Res Opin 17(2):96–104

    CAS  PubMed  Google Scholar 

  • McQuaid E, Kopel S, Klein R, Fritz G (2003) Medication adherence in pediatric asthma: reasoning, responsibility, and behavior. J Pediatr Psychol 28:323–333

    Article  PubMed  Google Scholar 

  • Melnikow J, Kiefe C (1994) Patient compliance and medical research: issues in methodology. J Gen Intern Med 9:96–105

    Article  CAS  PubMed  Google Scholar 

  • Purucker ME, Rosebraugh CJ, Zhou F, Meyer RJ (2003) Inhaled fluticasone propionate by diskus in the treatment of asthma. Chest 124:1584–1593

    Article  CAS  PubMed  Google Scholar 

  • Rabe KF, Adachi M, Lai CK et al (2004) Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol 114:40–47

    Article  PubMed  Google Scholar 

  • Rand C (2005) Non-adherence with asthma therapy: more than just forgetting. J Pediatr 146:157–159

    Article  PubMed  Google Scholar 

  • Rand CS, Wise R (1996) Adherence with asthma therapy in the management of asthma: review and clinical guidelines. In: Szefler SJ, Leung DYM (eds) Severe asthma: pathogenesis and clinical management. Marcel Dekker, New York, pp 436–464

    Google Scholar 

  • Schatz M, Cook EF, Nakahiro R, Petitti D (2003) Inhaled corticosteriods and allergy speciality care reduce emergency hospital use for asthma. J Allergy Clin Immunol 111:503–508

    Article  PubMed  Google Scholar 

  • Sherman J, Hutson A, Baumstein S, Hendeles L (2000) Telephoning the patient’s pharmacy to assess adherence with asthma medications by measuring refill rate for prescriptions. J Pediatr 136(4):532–535

    Article  CAS  PubMed  Google Scholar 

  • Sherman J, Patel P, Hutson A, Chesrown S, Hendeles L (2001) Adherence to oral montelukast and inhaled fluticasone in children with persistent asthma. Pharmacotherapy 21(12):1464–1467

    Article  CAS  PubMed  Google Scholar 

  • Simmons MS, Nides M, Rand C (2000) Unpredictability of deception in compliance with physician-prescribed bronchodilator inhaler use in clinical trial. Chest 118:290–295

    Article  CAS  PubMed  Google Scholar 

  • Stempel DA, Roberts CS, Stanford RH (2004) Treatment patterns in the months prior to and after asthma-related emergency department visit. Chest 126:75–80

    Article  PubMed  Google Scholar 

  • Stoloff SW, Stempel DA, Meyer J, Stnaford RH, Rosenzweig JR (2004) Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies. J Allergy Clin Immunol 113(2):245–251

    Article  PubMed  Google Scholar 

  • Suissa S, Ernst P, Benayoun S, Baltzan M, Cai B (2000) Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med 343:332–336

    Article  CAS  PubMed  Google Scholar 

  • Szefler S, Weiss SR, Tonascia J, Childhood Asthma Management Program Group (2000) Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 15:1054–1063

    Google Scholar 

  • Tuggey J, Hosker HS, Chetcuti P, Brownlee K, Taylor J, MacGowan C (2001) Choice of add-on therapy in asthma – another inhaler or a tablet/syrup? A survey of 1415 UK asthmatics. Prim Care Respir J 10(1):27–30

    Google Scholar 

  • Volovitz B, Duenas-Meza E, Chmielewska-Szewczyk DA et al (2000) Comparison of oral montelukast and inhaled cromolyn with respect to preference, satisfaction, and adherence: a multicenter, randomized, open-label, crossover study in children with mild to moderate persistent asthma. Curr Ther Res 61(7):490–506

    Article  CAS  Google Scholar 

  • Walders N, Kopel SJ, Koinis-Mitchell D, McQuaid EL (2005) Patterns of quick-relief and long-term controller medication use in pediatric asthma. J Pediatr 146:177–182

    Article  PubMed  Google Scholar 

  • Weinberg EG, Naya I (2000) Treatment preferences of adolescent patients with asthma. Pediatr Allergy Immunol 11:49–55

    Article  CAS  PubMed  Google Scholar 

  • Williams LK, Pladevall M, Xi H et al (2004) Relationship between adherence to inhaled corticosteriods and poor outcomes among adults with asthma. J Allergy Clin Immunol 114:1288–1293

    Article  CAS  PubMed  Google Scholar 

  • Winnick S, Luca D, Hartment AL, Toll D (2005) How do you improve compliance? Pediatrics 115:718–724

    Article  Google Scholar 

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Authors and Affiliations

  1. Pediatric Behavioral Health, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO, 80206, USA

    Bruce G. Bender

Authors
  1. Bruce G. Bender
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  2. Vasilisa Sazonov
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  3. Karl J. Krobot
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Corresponding author

Correspondence to Bruce G. Bender .

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Editors and Affiliations

  1. College of Health & Human Services, University of North Carolina, Charlotte, University City Blvd. 9201 , Charlotte, 28223-0001, U.S.A.

    Andrew Harver

  2. Dept. Psychology, Ohio University, Porter Hall 200, Athens, 45701, U.S.A.

    Harry Kotses

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Bender, B.G., Sazonov, V., Krobot, K.J. (2010). Impact of Medication Delivery Method on Patient Adherence. In: Harver, A., Kotses, H. (eds) Asthma, Health and Society. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78285-0_7

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  • DOI: https://doi.org/10.1007/978-0-387-78285-0_7

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