Impact of Medication Delivery Method on Patient Adherence

  • Bruce G. Bender
  • Vasilisa Sazonov
  • Karl J. Krobot


In this chapter, we provide a systematic review of randomized controlled trials, meta-analysis, case-control, or cohort studies that compared patient adherence with, or preference for, oral or inhaled controller medication for asthma. Among 17 studies meeting inclusion criteria for our review, patients were more adherent to oral than inhaled medications. Where queried, patients or parents expressed preference for oral medications. These findings were consistent across study designs, using contrasting measures of adherence, over varied time periods and including many with 12-month follow-up, and with patients who knew they were being monitored as well as those included in an anonymous database. Indirect evidence indicates that patient’s preference for oral medication is not related to dosing frequency.


Oral Medication Meet Inclusion Criterion Pharmacy Claim Great Adherence Cromolyn Sodium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Bruce G. Bender
    • 1
  • Vasilisa Sazonov
  • Karl J. Krobot
  1. 1.Pediatric Behavioral HealthNational Jewish Medical and Research CenterDenverUSA

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