Host Cell Actin Remodeling in Response to Cryptosporidium

  • Steven P. O’Hara
  • Aaron J. Small
  • Xian-Ming Chen
  • Nicholas F. LaRusso
Part of the Subcellular Biochemistry book series (SCBI, volume 47)


Despite sporadic reports of Cryptosporidium infection throughout the 1900s, the clinical significance of this parasite in humans was not recognized until the first documented human diagnosis of C. parvum in 1976,1,2 and the subsequent realization that as an opportunistic infectious agent, Cryptosporidium infection in AIDS patients was associated with significant morbidity and mortality3,4 and a causative agent of AIDS-related biliary disease.5 With the advent of highly active antiretroviral therapy, AIDS-related cryptosporidial disease occurs less frequently, yet Cryptosporidium is now recognized as a widely dispersed parasite and a significant enteropathogen of immunocompetent and immunocompromised hosts. Two species, C. hominis and C. parvum, readily infect humans. While C. parvum infects a wide range of mammalian hosts, C. hominis is believed to infect only humans. Most of the experimental evidence of host cell actin remodeling to date has been accomplished using C. parvum.


Actin Polymerization Cryptosporidium Parvum Membrane Protrusion Actin Reorganization Cryptosporidium Infection 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Steven P. O’Hara
    • 1
  • Aaron J. Small
    • 1
  • Xian-Ming Chen
    • 1
  • Nicholas F. LaRusso
    • 1
  1. 1.Miles and Shirley Fiterman Center for Digestive DiseasesMayo ClinicRochesterUSA

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