Role of the gp85/Trans-Sialidase Superfamily of Glycoproteins in the Interaction of Trypanosoma cruzi with Host Structures

  • Maria Júlia M. Alves
  • Walter Colli
Part of the Subcellular Biochemistry book series (SCBI, volume 47)


Invasion of mammalian cells by T. cruzi trypomastigotes is a multi-step and complex process involving several adhesion molecules, signaling events and proteolytic activities. From the blood to the cell target in different tissues the parasite has to interact with different cells and the extracellular matrix (ECM). The review focus on the role of the gp85/trans-sialidase superfamily members in the interaction of the parasite with the host cell, particularly with ECM components, with emphasis on the significant variability among the ligands and receptors involved. Use of the SELEX technique to evolve nuclease-resistant RNA aptamers for receptor identification is briefly discussed.


Sialic Acid Heparan Sulfate Trypanosoma Cruzi Host Structure Parasitophorous Vacuole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.Departamento de Bioquímica, Instituto de QuímicaUniversidade de São PauloSao PauloBrazil

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