Transepithelial Migration by Toxoplasma

  • Antonio Barragan
  • Niclas Hitziger
Part of the Subcellular Biochemistry book series (SCBI, volume 47)


A hallmark of T. gondii infections is passage of parasites across restrictive biological barriers—intestine, blood-brain barrier, blood-retina barrier and placenta—during primary infection or reactivation of chronic disease. Traversal of cellular barriers permits rapid dissemination of parasites to gain access to biologically restricted organs. This process involves active parasite motility and tighdy regulated interactions between host cell receptors and parasite adhesins that facilitate paracellular transfer. Mounting evidence also suggests that parasites use migrating leukocytes as Trojan horses to disseminate in the organism while avoiding immune attack. Thus, the interaction of Toxoplasma with biological barriers is a determinant factor of human toxoplasmosis. The elucidation of determinants involved in the process of migration may reveal virulence factors and novel therapeutic targets to combat disease.


Toxoplasma Gondii Bioluminescence Imaging Trojan Horse Biological Barrier Apicomplexan Parasite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.Karolinska InstitutetSwedish Institute for Infectious Disease Control and Center for Infectious MedicineStockholmSweden

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