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Plasmodium Sporozoite Passage across the Sinusoidal Cell Layer

  • Chapter
Molecular Mechanisms of Parasite Invasion

Part of the book series: Subcellular Biochemistry ((SCBI,volume 47))

Abstract

Malaria sporozoites must cross at least two cell barriers to reach their initial site of replication in the mammalian host. After transmission into the skin by an infected mosquito, they migrate towards small dermal capillaries, traverse the vascular endothelial layer,1,2 and rapidly home to the liver. To infect hepatocytes, the parasites must cross the sinusoidal cell layer, composed of specialized highly fenestrated sinusoidal endothelia and Kupffer cells, the resident macrophages of the liver (Fig. 1). The exact route Plasmodium sporozoites take to hepatocytes has been subject of controversial discussions for many years. Recent cell biological, microscopic, and genetic approaches have considerably enhanced our understanding of the initial events leading to the establishment of a malaria infection in the liver (for recent reviews see refs. 3–8).

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Authors and Affiliations

  1. Department of Medical Parasitology, New York University School of Medicine, New York, New York, USA

    Ute Frevert

  2. Department of Medical Parasitology, NYU School of Medicine, 341 E. 25 Street, New York, New York, 10010, USA

    Ivan Usynin, Kerstin Baer & Christian Klotz

Authors
  1. Ute Frevert
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  2. Ivan Usynin
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  3. Kerstin Baer
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  4. Christian Klotz
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Correspondence to Ute Frevert .

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Editors and Affiliations

  1. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

    Barbara A. Burleigh PhD

  2. Department of Biological Sciences, Imperial College, London, UK

    Dominique Soldati-Favre PhD

  3. Département de Microbiologie et Medecine Moléculaire, Université de Genève, Geneve, Switzerland

    Dominique Soldati-Favre PhD

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Frevert, U., Usynin, I., Baer, K., Klotz, C. (2008). Plasmodium Sporozoite Passage across the Sinusoidal Cell Layer. In: Burleigh, B.A., Soldati-Favre, D. (eds) Molecular Mechanisms of Parasite Invasion. Subcellular Biochemistry, vol 47. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78267-6_15

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