Plasmodium Sporozoite Passage across the Sinusoidal Cell Layer

  • Ute Frevert
  • Ivan Usynin
  • Kerstin Baer
  • Christian Klotz
Part of the Subcellular Biochemistry book series (SCBI, volume 47)


Malaria sporozoites must cross at least two cell barriers to reach their initial site of replication in the mammalian host. After transmission into the skin by an infected mosquito, they migrate towards small dermal capillaries, traverse the vascular endothelial layer,1,2 and rapidly home to the liver. To infect hepatocytes, the parasites must cross the sinusoidal cell layer, composed of specialized highly fenestrated sinusoidal endothelia and Kupffer cells, the resident macrophages of the liver (Fig. 1). The exact route Plasmodium sporozoites take to hepatocytes has been subject of controversial discussions for many years. Recent cell biological, microscopic, and genetic approaches have considerably enhanced our understanding of the initial events leading to the establishment of a malaria infection in the liver (for recent reviews see refs. 3, 4, 5, 6, 7, 8).


Kupffer Cell Liver Stage Parasitophorous Vacuole Liver Sinusoid Sinusoidal Cell 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Ute Frevert
    • 1
  • Ivan Usynin
    • 2
  • Kerstin Baer
    • 2
  • Christian Klotz
    • 2
  1. 1.Department of Medical ParasitologyNew York University School of MedicineNew YorkUSA
  2. 2.Department of Medical ParasitologyNYU School of MedicineNew YorkUSA

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