Risk Factors Intervention

  • K.G. Manton
  • Igor Akushevich
  • Julia Kravchenko
Part of the Statistics for Biology and Health book series (SBH)

Environmental Risk Factor Contribution to Cancer and Noncancer Diseases

Age–incidence relationships and experimental evidence suggest that cancer is a polygenic multifactorial disease, where the environmental components are important causes of most cancer types (see Chapter 3). A recent study of 90,000 twins (Lichtenstein et al., 2000) showed that the nonshared random environmental effect was the largest factor for all cancers, accounting for 58–82% of the total variation. Various environmental factors, sometimes isolated, but most often in combinations, influence human health, contributing to both cancer and noncancer deaths, including such leading death causes as cardio- and cerebrovascular diseases, cancer, and chronic obstructive pulmonary disease.

Risk factor intervention analysis is used for investigating how systematic changes of age-specific values of parameters, featuring one or group of risk factors, impact life expectancy, mortality, morbidity, and other demographic and...


Smoking Prevalence Smoking Rate Conventional Risk Factor Secondary Infertility Population Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • K.G. Manton
    • 1
  • Igor Akushevich
    • 1
  • Julia Kravchenko
    • 1
  1. 1.Duke UniversityDurhamUSA

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