U.S. Cancer Morbidity: Modeling Age-Patterns of Cancer Histotypes

  • K.G. Manton
  • Igor Akushevich
  • Julia Kravchenko
Part of the Statistics for Biology and Health book series (SBH)


In this chapter, we use modeling to study the features of possible mechanisms of carcinogenesis that may underlie morbidity trends described in Chapter 6. Hypotheses considered include that (1) observed data represent a mixture of diseases, each of which can be described by different models or by a model with different combinations of parameters, and (2) the main differences are due to cancer histotypes contributing to observed cancer incidence patterns. Hence, the model represents disease heterogeneity by estimating histotype-specific incidence rates. Other factors, which may contribute to heterogeneity of cancer incidence, include unobserved factors, such as a genetic predisposition and other host-related features that modulated cancer risk when exposed to risk factors. Analytic approaches used in this chapter include the models of carcinogenesis reviewed in Chapter 2, as well as their generalizations, such as the two-disease model (see Chapter 4). Analysis of the...


Cervical Cancer Black Male Lobular Carcinoma Black Female Cervix Uterus 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • K.G. Manton
    • 1
  • Igor Akushevich
    • 1
  • Julia Kravchenko
    • 1
  1. 1.Duke UniversityDurhamUSA

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