Regulatory T Cells and Disease State

  • Manzoor M. Khan


The immune response is designed to protect human and other organisms from disease-causing agents; it also protects against detrimental responses to self. The immune system needs to be strictly regulated because of its ability to produce inflammatory mediators, killer cells and antibodies, which are synthesized to eliminate the invading organisms, but can also harm other normal cells. Consequently, an immune response not only can produce autoimmunity but also is capable of producing other diseases due to its ability to attack normal cells that are damaged mainly by the inflammatory cytokines in a collateral damage. A number of regulatory mechanisms keep these harmful effects of the immune response in check.

Immune response is triggered by antigen presentation to the TCR in the context of MHC molecules, resulting in the activation and proliferation of CD4+ cells and secretion of cytokines. This activation also causes CD4+T cells to express a number of cell surface...


Treg Cell Mature Dendritic Cell Primary Immune Response Foxp3 Gene Induce Treg Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Creighton University Medical CenterOmahaUSA

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