Regulatory T Cells and Disease State



Treg Cell Mature Dendritic Cell Primary Immune Response Foxp3 Gene Induce Treg Cell 
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  1. Allez M, Mayer L. 2006. Regulatory T cells, peace keepers in the gut. Inflamm Bowel Dis. 10:666–676.CrossRefGoogle Scholar
  2. Baecher-Allan C, Hafler DA. 2004. Suppressor T cells in human disease. J Exp Med. 200:273–276.PubMedCrossRefGoogle Scholar
  3. Baecher-Allan C, Hafler DA. 2006. Human regulatory T cells and their role in autoimmune disease. Immunol Rev. 212:203–216.PubMedCrossRefGoogle Scholar
  4. Barnett Z, Larussa SH, Hogam M, Wei S, et al. 2004. Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals. Cancer Res. 64:8451–8455.PubMedCrossRefGoogle Scholar
  5. Battaglia M, Gregori S, Bacchetta R, Roncarolo MG. 2006. Tr 1 cells: From discovery to their clinical application. Semin Immunol. 18:120–127.PubMedCrossRefGoogle Scholar
  6. Beissert S, Schwarz A, Schwarz T. 2006. Regulatory T cells. J Invest Dermatol. 126:15–24.PubMedCrossRefGoogle Scholar
  7. Belkaid Y, Rouse BJ. 2005. Natural regulatory T cells in infectious disease. Nat Immunol. 6: 353–360.PubMedCrossRefGoogle Scholar
  8. Beyer M, Schultze JL. 2007. CD 4+CD25+high Foxp3+ regulatory T cells in peripheral blood are primarily of effector memory phenotype. J Clin Oncol. 25:2628–2630.PubMedCrossRefGoogle Scholar
  9. Bluestone JA, Abbas AK. 2003. Natural versus adaptive regulatory T cells. Nat Rev Immunol. 3:253–257.PubMedCrossRefGoogle Scholar
  10. Bluestone JA. 2004. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci USA. 101:14622–14626.Google Scholar
  11. Brimnes J, Allez M, Dotan I, Mayer L. 2005. Defects in CD8+ regulatory T cells in the Lamina Propria of patients with inflammatory bowel disease. J Immunol. 174:5814–5822.PubMedGoogle Scholar
  12. Buckner JH, Ziegler SF. 2004. Regulating the immune system: The induction f regulatory T cells in periphery. Arthritis Res Ther. 6:215–222.PubMedCrossRefGoogle Scholar
  13. Cao D, Vollenhoven RV, Klareskog L, Trollmo C, Malstrom V. 2004. CD 25+CD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther. 6:R335–346.PubMedCrossRefGoogle Scholar
  14. Chatenoud L, Salomon B, Bluestone JA. 2001. Suppressor T cells – they’re back and critical for regulation of autoimmunity! Immunol. Rev. 182:149–163.Google Scholar
  15. Chen Z, Benoist C, Mathis D. 2005. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci USA. 102:14735–14740.Google Scholar
  16. Cohen IR, Quintana FJ, Mimran A. 2004. Tregs in T cell vaccination: Exploring the regulation of regulation. J Clin Inv. 114:1227–1232.Google Scholar
  17. Dejaco C, Duftner C, Grubeck-Loebenstein B, Schrimer M. 2006. Imbalance of regulatory T cells in human autoimmune diseases. Immunology. 117:289–300.PubMedCrossRefGoogle Scholar
  18. Dieckmann D, Bruett CH, Ploettner H, Lutz MB, Schuler G. 2002. Human CD4+CD25+ regulatory, contact-dependent T cells induce interleukin 10 producing, contact-independent type 1-regulatory T cells. J Exp Med. 196:247–253.PubMedCrossRefGoogle Scholar
  19. Fehervari Z, Sakaguchi S. 2004. CD 4+ Tregs and immune control. J Clin Inv. 114:1209–1217.Google Scholar
  20. Ferretti G, Felici A, Pino MS, Cognetti F. 2006. Does CTLA4 influence the suppressive effects of CD25+CD4+ regulatory T cells? J Clin Oncol. 24:5469–5470.PubMedCrossRefGoogle Scholar
  21. Fields RC, Bharat A, Mohanakumar T. 2006. The role of regulatory T-cells in transplantation tolerance. ASHI Quarterly. (first quarter):10–15.Google Scholar
  22. Franzece O, Kennedy PTF, Gehring AJ, Gotto GM., et al. 2005. Modulation of the CD8+ T cell response by CD4+CD25+ regulatory T cells in patients with Hepatitis B virus infection. J Virol. 79:3322–3328.CrossRefGoogle Scholar
  23. Gershon RK, Kondo K. 1970. Cell interactions in the induction of tolerance: The role of thymic lymphocytes. Immunology. 18:723–737.PubMedGoogle Scholar
  24. Gershon RK. 1975. A disquisition on suppressor T cells. Transplant Rev. 26:170–185.PubMedGoogle Scholar
  25. Godfrey DI, Kronenberg M. 2004. Going both ways: Immune regulation via CD1d-dependent NKT cells. J Clin Inv. 114:1379–1388.Google Scholar
  26. Gould HJ, Sutton BJ, et al. 2003. The biology of IgE and the basis of the allergic disease. Ann Rev Immunol. 21:579–628.CrossRefGoogle Scholar
  27. Green DR, Flood PM, Gershon RK. 1983. Immuno -regulatory T cell pathways. Ann Rev Immunol. 1:439–463.CrossRefGoogle Scholar
  28. Groux H. 2003. Type 1 T-regulatory cells: Their role in the control of immune response. Transplantation. 75:85–125.CrossRefGoogle Scholar
  29. Hawrylowicz CM, O’Garra A. 2005. Potential role of interleukin-10 secreting regulatory T cells in allergy and asthma. Nat Rev Immunol. 5:271–283.PubMedCrossRefGoogle Scholar
  30. Hong J, Zang YC, Nie H, Zhong J. 2006. CD 4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis, PNAS. 103:5024–5029.PubMedCrossRefGoogle Scholar
  31. Hori S, Nomura T, Sakaguchi S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057–1061.PubMedCrossRefGoogle Scholar
  32. Ito T, Wang Y-H, Duramad O, Hanabuchi S, et al. 2006. OX 40 ligand shuts down IL-10 producing regulatory T cells. PNAS. 103:13188–13141.Google Scholar
  33. Iwashiro M, Messer RJ, Peterson KE, Stronnes IM, et al. 2001. Immunosuppression of CD4+ regulatory T cells induced by chronic retroviral infection. PNAS. 98:9226–9230.PubMedCrossRefGoogle Scholar
  34. Janeway Jr. C. 1988. Do suppressor T cells exist? A reply. Scand J Immunol. 27:621–623.PubMedCrossRefGoogle Scholar
  35. Jerne NK. 1974. Towards a network theory of the immune system. Ann Immunol. 125:373–389.Google Scholar
  36. Joosten SA, Meigjaarden KE, Savage N, Boer TD, et al. 2007. Identification of a human CD8+ regulatory T cells subset that mediates suppression through the chemokine CC chemokine ligand 4. PNAS, 104:8029–8034.PubMedCrossRefGoogle Scholar
  37. Karlsson MR, Rugtveit J, Brandtzaeg P. 2004. Allergen -responsive CD4+CD25+ regulatory T cells in children who have outgrown cow’s milk allergy. J Exp Med 12:1679–1688.CrossRefGoogle Scholar
  38. Kim JM, Rudensky A. 2006. The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunol Rev. 212:86–98.PubMedCrossRefGoogle Scholar
  39. Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK. 2005. Sequential development of interleukin 2-depdent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med. 202:1375–1386.PubMedCrossRefGoogle Scholar
  40. Kretschmer K, Apostolou I, Jaechel E, Khazaie K., et al. 2006. Making regulatory T cells with defined antigen specificity: Role in autoimmunity and cancer. Immunol Rev. 212:163–169.PubMedCrossRefGoogle Scholar
  41. Latour RP, Dujardin HC, Mishellany F, Defranoux OB, et al. 2006. Ontogeny , function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7. Blood. 108: 2300–2306.CrossRefGoogle Scholar
  42. Liu H, Komai-Koma M, Xu D, Liew FY. 2005, Toll-like receptor2 signaling modulates the function of CD4+CD25+ regulatory T cells. PNAS. 103:7048–7053.CrossRefGoogle Scholar
  43. Lohr J, Knowchel B, Abbas AK. 2006. Regulatory T cells in periphery. Immunol Rev. 212: 149–162.PubMedCrossRefGoogle Scholar
  44. Lu L, Wermeck MBF, Cantor H. 2006. The immunoregulatory effects of Qα-1. Immunol Rev. 212:51–59.PubMedCrossRefGoogle Scholar
  45. Masteller EL, Tang Q, Bluestone JA. 2006. Antigen -specific regulatory T cells-ex vivo expansion and therapeutic potential. Semin Immunol. 18:103–110.PubMedCrossRefGoogle Scholar
  46. Nishizuka Y, Sakakura T. 1969. Thymus and reproduction: Sex linked dysgenesia of the gonad after neonatal thymectomy in mice. Science. 166:753–755.PubMedCrossRefGoogle Scholar
  47. O’Garra A, Vieira P. 2004. Regulatory T cells and mechanisms of immune system control. Nat Med. 10:801–805.PubMedCrossRefGoogle Scholar
  48. O’Garra A, Vieira P, Goldfeld A. 2004. IL -10 producing and naturally occurring CD4+ Tregs: Limiting collateral damage. J Clin Inv. 114:1372–1378.Google Scholar
  49. Picca CC, Larkin III J, Boesteanu A, Lerman MA, Rankin AL, Caton AJ. 2006. Role of TCR specificity in CD4+CD25+ regulatory T cell selection. Immunol Rev. 212:74–85.PubMedCrossRefGoogle Scholar
  50. Qizhi T, Bluestone JA. 2006. Regulatory T cell physiology and application to treat autoimmunity. Immunol Rev. 212:217–237.CrossRefGoogle Scholar
  51. Reibke R, Garbi N, Hammerling GH, et al. 2006. CD 8+ regulatory T cells generated by neonatal recognition of peripheral self antigen. PNAS. 103:15142–15147.PubMedCrossRefGoogle Scholar
  52. Roncarlo MG, Gregori S, Battaglia M, Bacchetta R, et al. 2006. Interleukin -10 secreting type 1 regulatory T cells in rodents and humans. Immunol Rev. 212:28–50.CrossRefGoogle Scholar
  53. Rouse BT, Sarangi PP, Suvas S. 2006. Regulatory T cells in virus infections. Immunol Rev. 212:272–286.PubMedCrossRefGoogle Scholar
  54. Sakaguchi S. 2004. Naturally arising CD4+ regulatory T cells for immunologic self tolerance and negative control of immune response. Ann Rev Immunol. 22:531–562.CrossRefGoogle Scholar
  55. Sakaguchi S. 2005. Naturally arising Foxp3-expressing Cd25+CD4+ regulatory T cells in immunological tolerance to self and nonself. Nat Immunol. 6:345–352.PubMedCrossRefGoogle Scholar
  56. Sakaguchi S. 2006. Regulatory T cells: Meden Agan, Immunological reviews, 212:1–5.Google Scholar
  57. Sakaguchi S, Ono M, Setoguchi R, Yagi H, et al. 2006. Foxp 3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 212:8–27.PubMedCrossRefGoogle Scholar
  58. Sansom DM, Walker LS. 2006. The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T cell biology. Immunol Rev. 212:131–148.PubMedCrossRefGoogle Scholar
  59. Schultze JL. 2006. Regulatory T cells: Timing is everything. Blood. 107:857.Google Scholar
  60. Shevach EM. 2000. Regulatory T cells in autoimmunity. Ann Rev Immunol. 18:423–449.CrossRefGoogle Scholar
  61. Shevach EM. 2002. CD 4+CD25+ suppressor T cells: More questions than answers. Nat Rev Immunol. 2:389–400.PubMedGoogle Scholar
  62. Shevack EM. 2004. Fatal attraction: Tumors beckon regulatory T cells. Nat Med. 10:900–901.CrossRefGoogle Scholar
  63. Shevach EM, DiPaolo RA, Anderson J, Zhao DM. 2006. The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells. Immunol Rev. 212:60–73.PubMedCrossRefGoogle Scholar
  64. Snoeck V, Peters I, Cox E. 2006. The IgA system. Vet Res. 37:455–467.PubMedCrossRefGoogle Scholar
  65. Sutmuller RPM, den Brok HMGM, Kramer M, Bennink EJ, et al. 2006. Toll -like receptors control expansion and function of regulatory T cells. J Clin Invest. 116:485–494.Google Scholar
  66. Taams LS, Palmer DB, Akbar AN, Robinson DS, et al. 2006. Regulatory T cells in human disease and their potential for therapeutic manipulation. Immunology. 118:1–9.PubMedCrossRefGoogle Scholar
  67. Tarbell KV. Yamazaki S, Steinman RM. 2006. The interaction of dendritic cells with antigen specific, regulatory T cells that suppress autoimmunity. Semin Immunol. 18:93–102.Google Scholar
  68. Thomas D, Zaccone P, Cooke A. 2005. The role of regulatory T cell defects in Type I diabetes and the potential of these cells for therapy. Rev Diabet Stud. 2:9–18.PubMedCrossRefGoogle Scholar
  69. Umetsu DT, DeKruyff RH. 2006. The regulation of allergy and asthma. Immunol Rev. 212: 238–255.PubMedCrossRefGoogle Scholar
  70. Vigouroux S, Yvon E, Biagi E, Brenner MK. 2004. Antigen -induced regulatory T cells. Blood. 104:26–33.PubMedCrossRefGoogle Scholar
  71. Walker LS, Chodos A, Eggena M, Dooms H, Abbas AK. 2003. Antigen -dependent proliferation of CD4+CD25+ regulatory T cells in vivo. J Exp Med. 198:249–258.PubMedCrossRefGoogle Scholar
  72. Walsh PT, Taylor DK, Turka LA. 2004. Tregs and transplantation tolerance. J Clin Inv. 114: 1398–1403.Google Scholar
  73. Walsh PT, Buckler JL, Zhang J, Gelman AE, et al. 2006. PTEN inhibits IL-2 receptor mediated expansion of CD4+CD25+ Tregs. J Clin Inv. 116:2521–2531.Google Scholar
  74. Wan YY, Flavell RA. 2006. The roles for cytokines in the generation and maintenance of regulatory T cells. Immunol Rev. 212:114–130.PubMedCrossRefGoogle Scholar
  75. Wau Y, Flavell RA. 2007. Regulatory T cell functions are subverted and converted owing to attenuated FoxP-3 expression. Nature. 445:766–770.CrossRefGoogle Scholar
  76. You S, Thieblemont N, Alayankian MA, Bach J, Chatenoud L. 2006. Transforming growth factor-β and T-cell-mediated immunoregulation in the control of autoimmune diabetes. Immunol Rev. 212:185–202.PubMedCrossRefGoogle Scholar
  77. Zorn E, Nelson EA, Mohseni M, Porchery F, et al. 2006. IL -2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expression of these cells in vivo. Blood. 108:1571–1579.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Creighton University Medical CenterOmahaUSA

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