Acquired Immune Deficiency Syndrome

  • Manzoor M. Khan


In 1959, a Bantu man died of an unidentified illness in Belgian Congo, and later analysis of his blood samples confirmed him to be the first case of HIV infection. Human immunodeficiency virus-1 (HIV-1) and -2 (HIV-2), which cause AIDS, evolved from strains of simian immunodeficiency virus SIVepz and SIVsm, respectively. SIVepz infects a subspecies of chimpanzees and SIVsm infects sooty mangabeys but AIDS is not observed in these hosts. Humans may have been exposed to SIV, but these strains are not able to adapt, infect and transmit between humans. It is suggested that HIV-1 originated from a subspecies of chimpanzees as HIV-1 groups M and N have their origins in a distinct population of chimpanzees in Cameroon. The spread may have started after World War II. It is not known how many people developed this disease in the 1970s or before that, but in 1978 gay men in the United States and Sweden and heterosexuals in Haiti and Tanzania exhibited symptoms that were later...


Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Nonnucleoside Reverse Transcriptase Inhibitor Viral Protease Human Immunodeficiency Virus Protease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Creighton University Medical CenterOmahaUSA

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