Tissue Transplantation

  • Manzoor M. Khan


The concept of transplantation may go back to the stories of chimeras including sphinxes and mermaids. According to a third-century legend of Saints Cosmas and Damian, these two brother physicians replaced the cancerous leg of a church sacristan using the limb of a dead Moor. It is suggested that about 2000 years ago, transplantation surgery was done for nose reconstruction by Vaidya, the Ayurvedic physicians. Gaspare Tagliacozzi in the late sixteenth century performed reconstructive rhinoplasty by using skin from the arms of the patients. The allografts of skin always failed and no further progress was reported until the twentieth century.

The original experiments of tissue transplantation were done by using skin transplants in inbred strains of mice. In 1908, Alexis Carrel first reported kidney transplantation in cats, but all the cats died, and only some exhibited a functional urinary output. George Schone published in 1912 the difficulties associated with tissue...


Blood Group Acute Rejection Chronic Rejection Acute Cellular Rejection Human Leukocyte Antigen Typing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Creighton University Medical CenterOmahaUSA

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