Allergic Disease

  • Manzoor M. Khan


The term allergy (from Greek allos, meaning “other,” and ergon, meaning “work”) was introduced in 1906 by von Priquet. Atopy (from Greek, meaning “out of place”) is also used to describe allergic disease. In 1919, a physician first reported allergy-related symptoms of transient asthma following blood transfusion. In the study, a response to horse dander suggested that an allergic reaction could be mediated by a factor in the blood. The passive transfer of a positive skin test performed by Prausnitz and Kustner in an experiment in 1921 led to a search to discover the substances responsible for allergic reaction. Until 1960 the focus was on several labile complexes in the serum rather than on one molecule, and it was assumed that antibodies were not involved in allergic reaction.

In 1965, Bennick and Johansson in Sweden reported a new class of immunoglobulin called IgND, and it was subsequently found that the levels of IgND were severalfold higher in allergic asthmatics than...


Mast Cell Atopic Eczema Allergic Rhinitis Allergic Disease House Dust Mite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Creighton University Medical CenterOmahaUSA

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