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Monoclonal Antibodies as Therapeutic Agents

  • Manzoor M. Khan
Chapter

Introduction

In 1895, Hericourt and Richet reported the first clinical trials testing the principle of antibody production. They injected cancer cells into animals to obtain antiserum to treat cancer patients; this was the first time several patients with cancer were administered tailor-made serum for treatment. Several patients showed improvement, which was encouraging, but none of the patients were completely cured. These trials were repeated in the early 1900s but the results were not consistent. The problems included the variability of the antisera and the side effects of polyclonal antibodies – some of which were directed against self.

Paul Ehrlich, at the beginning of the twentieth century, first proposed the concept of “magic bullets.” He reasoned that the development of compounds that selectively target a disease-causing organism could potentially deliver toxins to that organism. The specificity of antibodies, which are extremely specific and bind to and attack one particular...

Keywords

Acute Myeloid Leukemia Myeloma Cell Chimeric Monoclonal Antibody Chimeric Antibody Murine Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Creighton University Medical CenterOmahaUSA

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