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Overview of the Immune Response

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Bibliography

  • Abbas AK, Lichtman AH, Pober JS. 1994. Cellular and Molecular Immunology, WB Saunders Company, Philadelphia.

    Google Scholar 

  • Alacorn B, Swamy M, Van-Santen HM, Schamel WW. 2006. T cell antigen receptor stoichiometry: Pre-clustering for sensitivity. EMBO-Rep. 7:490–495.

    Google Scholar 

  • Allison TJ, Garboczi DN. 2002. Structure of γδ T cell receptors and their recognition of non-peptide antigens. Mol Immunol. 38:1051–1061.

    Article  PubMed  CAS  Google Scholar 

  • Arnold JN, Wormald MR, Sim RB, Rudd PM, Dwek RA. 2007. The impact of glycosylation on the biological function and structure of human immunoglobulins. Ann Rev Immunol. 25:21–50.

    Article  CAS  Google Scholar 

  • Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature. 392:245–252.

    Article  PubMed  CAS  Google Scholar 

  • Barclay A. 2003. Membrane proteins with immunoglobulin-domains – a master superfamily of interaction molecules. Sem Immunol. 15:215.

    Google Scholar 

  • Baron P, Constantin G, D’Andrea A, Ponzin D, et al. 1993. production of TNF and other proinflammatory cytokines by human mononuclear phagocytes stimulated with myelin P2 protein. Proc Natl Acad Sci USA. 90:4414–4418.

    Article  PubMed  CAS  Google Scholar 

  • Bazzoni F, Cassatella MA, Rossi F, Ceska M, et al. 1991. Phagocytosing neutrophils produce and release high amounts of the NaP-1/interleukin 8. J Exp Med. 173:771–774.

    Article  PubMed  CAS  Google Scholar 

  • Benichou G. 1998. The presentation of self and allogeneic MHC peptides to T lymphocytes. Hum Immunol. 59:540–561.

    Article  PubMed  CAS  Google Scholar 

  • Butcher E, Picker LJ. 1996. Lymphocyte homing and homeostasis. Science. 272:60–62.

    Article  PubMed  CAS  Google Scholar 

  • Cantrell D. 1996. T-cell antigen receptor signal transduction pathways. Ann Rev Immunol. 14:259.

    Article  CAS  Google Scholar 

  • Carayannopoulos L, Capra JD. 1993. Immunoglobulins: Structure and function. In: Paul WE, Ed. Fundamental Immunology. 3rd Ed., Raven Press, New York.

    Google Scholar 

  • Carreno LJ, Gonzales PA, Kalergis AM. 2006. Modulation of T cell function by TCR/pMHC binding kinetics. Immunobiology. 211:47–64.

    Article  PubMed  CAS  Google Scholar 

  • Cassatella MA. 1995. The production of cytokines by neutrophils. Immunol Today. 16:21–26.

    Article  PubMed  CAS  Google Scholar 

  • Cassatella MA. 1999. Neutrophil-derived proteins: selling cytokines by the pound. Adv Immunol. 73:369–509.

    Article  PubMed  CAS  Google Scholar 

  • Castellino F. 1997. Antigen presentation by MHC Class II molecules: Invariant chain function, protein trafficking and the molecular basis of diverse determinant capture. Hum Immunol. 54:159–169.

    Article  PubMed  CAS  Google Scholar 

  • Cella M, Sallusto F, Lanzavecchia A. 1997. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol. 9:10–16.

    Article  PubMed  CAS  Google Scholar 

  • Chien YH, Bonneville M. 2006. Gamma delta T cell receptors. Cell Mol Life Sci. 63:2089–2094.

    Article  PubMed  CAS  Google Scholar 

  • Chtanova T, MacKay CR. 2001. T cell effector subsets: extending the Th1/TH2 paradigm. Adv Immunol. 78:233–266.

    Article  PubMed  CAS  Google Scholar 

  • Colucci F, Caligiuri MA, DiSanto JP. 2003. What does it take to make a natural killer? Nat Rev Immunol. 3:413–425.

    Article  PubMed  CAS  Google Scholar 

  • Cooper MA, Fehniger TA, Calilgiuri MA. 2001. The biology of human natural killer-cell subsets. Trends Immunol. 22:633–640.

    Article  PubMed  CAS  Google Scholar 

  • Davis MM, Chien Y. 1995. Issues concerning the nature of antigen recognition by αβ and γδ T cell receptors. Immunol Today. 16:316–318.

    Article  PubMed  CAS  Google Scholar 

  • Dawicki W, Marshall JS. 2007. New and emerging roles for mast cells in host defence. Curr Opin Immunol. 19:31–38.

    Article  PubMed  CAS  Google Scholar 

  • Dianzani U, Malavasi F. 1995. Lymphocyte adhesion to endothelium. Crit Rev Immunol. 15:167–178.

    PubMed  CAS  Google Scholar 

  • Fernette PS, Wagner DD. 1996. Adhesion molecules. NEJM. 334:1526–1529.

    Google Scholar 

  • Fitzsimmons CM, McBeath R, Joseph S, Jones FM, Walter K, Hoffman KF, et al. 2007. Factors affecting human IgE and IgG responses to allergin-like schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposure. Int Arch Allergy Immunol. 142: 40–50.

    Article  PubMed  CAS  Google Scholar 

  • Gangadhavan D, Cheroutre H. 2004. The CD8 isoform CD8 alpha alpha is not a functional homologue of the TCR co-receptor CD8 alpha beta. Curr Opin Immunol. 16:264–270.

    Article  Google Scholar 

  • Geisler C. 2004. TCR trafficking in resting and stimulator T cells. Crit Rev Immunol. 24:67–86.

    Article  PubMed  CAS  Google Scholar 

  • Gleich G, Adolphson C. 1986. The eosinophilic leukocyte: Structure and function. Adv Immunol. 39:177–253.

    Article  PubMed  CAS  Google Scholar 

  • Godfrey DI. 2004. Natural killer T cells. Nat Rev Immunol. 4:231.

    Article  PubMed  CAS  Google Scholar 

  • Goldsby RA, Kindt TJ, Osborne BA. 2000. Kuby Immunology, WH Freeman and Company, New York.

    Google Scholar 

  • Greenwald RJ, Freeman GJ, Shapre AH. 2005. The B7 family revisited. Ann Rev Immunol, 23:515–548.

    Article  Google Scholar 

  • Grimbaldeston MA, Metz M, Yu M, Galli SJ. 2006. Effector and potential immunoregulatory role of mast cells in IgE-mediated acquired immune responses. Curr Opin Immunol. 18:751–760.

    Article  PubMed  CAS  Google Scholar 

  • Gurish MF, Boyce JA. 2006. Mast cells: Ontogeny, homing and recruitment of a unique innate effector cell. J All Clin Immunol. 117:1285–1291.

    Article  CAS  Google Scholar 

  • Hart DN. 1997. Dendritic cells: Unique leukocyte populations which control the primary immune response. Blood. 90:3245–3287.

    PubMed  CAS  Google Scholar 

  • Hofmeyr SA. 1997. An overview of the immune system. http://www.cs.unm.edu/~immsec/html-imm/introduction.html. Retrieved 8/7/07.

  • Hynes RO. 2004. The emergence of integrins: A personal and historical perspective. Matrix Biol. 23:333–340.

    Article  PubMed  CAS  Google Scholar 

  • Janeway CA. 1995. Ligands for the T cell receptors: Hard times for avidity models. Immunol Today. 16:223–225.

    Article  PubMed  CAS  Google Scholar 

  • Janeway CA, Travers P. 1996. Immunobiology, the immune system in health and disease. Current biology limited. London, San Francisco and Philadelphia, Garland publishing incorporated, New York and London.

    Google Scholar 

  • Jerud ES. 2006. Natural killer T cells: Roles in tumor immunosurveillance and tolerance. Trans Med Hemother. 33:18–36.

    Article  Google Scholar 

  • Kohler G, Milstein C. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 256:459.

    Article  Google Scholar 

  • Kuhns MS, Davis MM, Garcia KC. 2006. Deconstructing the form and function of the TCR/CD3 complex. Immunity. 24:133–139.

    Article  PubMed  CAS  Google Scholar 

  • Laky K, Fleischacker C, Fowlkes BJ. 2006. TCR and notch signaling in CD4 and CD8 T-cell development. Immunol Rev. 209:274–283.

    Article  PubMed  CAS  Google Scholar 

  • Lanier LL. 2005. NK cell recognition. Ann Rev Immunol. 23:225–274.

    Article  CAS  Google Scholar 

  • Lanzavecchia A, Lezzi G, Viola A. 1999. From TCR engagement to T cell activation: A kinetic view of T cell behavior. Cell. 96:1.

    Article  PubMed  CAS  Google Scholar 

  • Lehner PJ, Trowsdale J. 1998. Antigen presentation: coming out gracefully. Curr Biol. 8:R605–R621.

    Article  PubMed  CAS  Google Scholar 

  • Li H, Llera A, Mariuzza RA. 1998. Structure function studies of T cell receptor-superantigen interactions. Immunol Rev. 163:177–186.

    Article  PubMed  CAS  Google Scholar 

  • Liszewski MK, Yokoyama WM, Atkinson JP. 2000. Innate immunity: Innate immune cells. Immunology/Allergy, II Innate immunity, ACP Medicine, New York.

    Google Scholar 

  • Luo B, Springer TA. 2006. Integrin structures and conformational signaling. Curr Opin Cell Biol. 18:1–8.

    Article  Google Scholar 

  • Luo B, Carmen CV, Springer TA. 2007. Structural basis of integrin regulation and signaling. Ann Rev Immunol. 25:619–647.

    Article  CAS  Google Scholar 

  • Maruotti N, Crivellato E. Cantatore FP, Vacca A, Ribatti D. 2007. Mast cells in rheumatoid arthritis. Clin Rheumatol. 26:1–4.

    Article  PubMed  Google Scholar 

  • McDonald PP, Bald A, Cassatella MA. 1997. Activation of the NF-kB pathway by inflammatory stimuli in human PMN. Blood. 89:3421–3433.

    PubMed  CAS  Google Scholar 

  • Mellman I, Turley SJ, Steinman RM. 1998. Antigen processing for amateurs and professionals. Trends Cell Biol. 8:231–242.

    Article  PubMed  CAS  Google Scholar 

  • MHC Sequencing Consortium. 1999. complete sequence and gene map of a human major histocompatibility complex. Nature. 401:921–923.

    Article  Google Scholar 

  • Morgan R, Costello R, Durcan N, Kingham P, Gleich G, McLean W, Walsh M. 2005. Diverse effects of eosinophil cationic granule proteins in IMR-32 nerve cell signaling and survival. Am J Respir Cell Mol Biol. 33:169–177.

    Article  PubMed  CAS  Google Scholar 

  • O’Brien RL, Roark CL, Aydintug MK, French JD, et al. 2007. Gamma delta T cell receptors functional correlations. Immunol Rev. 215:77–88.

    Article  PubMed  Google Scholar 

  • Okkenhaug K, Ali K, Vanhaesebroek B. 2007. The antigen receptor signaling, a distinctive role for the p10 delta isoform of PI3 K. Trends Immunol. 28:80–87.

    Article  PubMed  CAS  Google Scholar 

  • Orange JS, Ballas ZK. 2006. Natural killer cells in human health and disease. Clin Immunol. 118:1–10.

    Article  PubMed  CAS  Google Scholar 

  • Pamer E, Cresswell P. 1998. Mechanisms of MHC Class I-restricted antigen processing. Ann Rev Immunol. 16:323–358.

    Article  CAS  Google Scholar 

  • Perussia B, Chen Y, Loza MJ. 2005. Peripheral NK cell phenotypes: Multiple changing of faces of an adapting, developing cell. Mol Immunol. 42:385–295.

    Article  PubMed  CAS  Google Scholar 

  • Pribila JT, Quale AC, Mueller KL, Shimizu Y. 2004. The integrins and T cell mediated immunity. Ann Rev Immunol. 22:157–180.

    Article  CAS  Google Scholar 

  • Prussin C, Metcalfe DD. 2003. IgE, mast cells, basophils and eosinophils. J Allergy Clin Immunol. 111:S486–S494.

    Article  PubMed  CAS  Google Scholar 

  • Reid CD. 1997. The dendritic cell lineage in haemopoiesis. Br J Hematol. 96:217–223.

    Article  CAS  Google Scholar 

  • Rogge L. 2002. A genomic view of helper T cell subsets. Ann N Y Acad Sci. 975:57–67.

    Article  PubMed  CAS  Google Scholar 

  • Rothenberg M, Hogan S. 2006. The eosinophil. Ann Rev Immunol. 24:147–174.

    Article  CAS  Google Scholar 

  • Sallusto F, Lanzavecchia A. 2002. The instructive role of dendritic cells on T cell responses. Arthritis Res. 4:S127–S132.

    Article  PubMed  Google Scholar 

  • Schwarz BA, Bhandoola A. 2006. Trafficking from the bone marrow to the thymus: a prerequisite for thrombopoiesis. Immunol Rev. 209:47–57.

    Article  PubMed  Google Scholar 

  • Springer TA. 1990. Adhesion receptors of the immune system. Nature. 346:425–434.

    Article  PubMed  CAS  Google Scholar 

  • Springer TA. 1993. Adhesion receptors in inflammation: A précis. In: Thomas ED, Carter SK, Eds. Application of Basic Scineces to Hemoatopoiesis and treatment of disease, Raven Press, New York, pp. 231–239.

    Google Scholar 

  • Springer TA. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell. 76:301–314.

    Article  PubMed  CAS  Google Scholar 

  • Steinman RM, Cohn ZA. 1973. Identification of a novel cell type in peripheral lymphoid organs of mice. I Morphology, quantitation, tissue distribution. J Exp Med. 137:1142–1162.

    Article  PubMed  CAS  Google Scholar 

  • Takhar P, Smurthwaite L, Coker HA, Fear DJ, et al. 2005. Allergen derives class switching to IgE in the nasal mucosa in allergic rhinitis. J Immunol. 174:5024–5032.

    PubMed  CAS  Google Scholar 

  • Theoharides TC, Kalogeromitros D. 2006. The critical role of mast cells in allergy and inflammation. Ann NY Acad Sci. 1088:78–99.

    Article  PubMed  CAS  Google Scholar 

  • Trulson A, Bystrom J, Engstrom A, Larsson R, Venge P. 2007. The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications. Clin Exp Allergy. 37:208–218.

    Article  PubMed  CAS  Google Scholar 

  • Venge P, Bystrom J, Carlson M, Hakansson L, Karawacjzyk M, Peterson C, Seveus L, Trulson A. 1999. Eosinophil cationic protein (ECP): Molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease. Clin Exp Allergy. 29:1172–1186.

    Article  PubMed  CAS  Google Scholar 

  • Vernon P, Allo V, Riviere C, Bernard J, et al. 2007. Major subsets of human dendritic cells are efficiently transduced by self-complementary Adeno-associated virus vectors 1 and 2. J Virol. 81:5385–5394.

    Article  Google Scholar 

  • Wiersma EJ, Collins C, Fazel S, Shulman MJ. 1998. Structural and functional analysis of J chain deficient IgM. J Immunol. 160:5979–5989.

    PubMed  CAS  Google Scholar 

  • Woof JM, Mestecky J. 2005. Mucosal immunoglobulins. Immunol Rev. 206:64–82.

    Article  PubMed  CAS  Google Scholar 

  • Yamasaki S, Takashi S. 2007. Molecular basis for a pre-TCR mediated autonomous signaling. Trends Immunol. 28:39–43.

    Article  PubMed  CAS  Google Scholar 

  • Young J, Peterson C, Venge P, Cohn Z. 1986. Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature. 321:613–616.

    Article  PubMed  CAS  Google Scholar 

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Khan, M.M. (2008). Overview of the Immune Response. In: Immunopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77976-8_1

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