Nosocomial and Community-acquired Acinetobacter Infections

  • M. L. Joly-Guillou
Part of the Infectious Agents and Pathogenesis book series (IAPA)


Infective Endocarditis Nosocomial Infection Intensive Care Unit Patient Prosthetic Valve Endocarditis Acinetobacter Species 


  1. Albrecht, M.A., Griffith, M.E., Murray, C.K., Chung, K.K., Horvath, E.E., Ward, J.A., Hospenthal, D.R., Holcomb, J.B., Wolf, S.E. 2006. Impact of Acinetobacter infection on the mortality of burn patients. J Am Coll Surg. 203:546–550.PubMedCrossRefGoogle Scholar
  2. Anstey, N.M., Currie, B.J., Hassell, M., Palmer, D., Dwyer, B., Seifert, H. 2002. Community-acquired bacteremic Acinetobacter pneumonia in tropical Australia is caused by diverse strains of Acinetobacter baumannii, with carriage in the throat in at-risk groups. J. Clin. Microbiol. 40:685–686.PubMedCrossRefGoogle Scholar
  3. Bayuga, S., Zeana, C., Sahni, J., Della-Latta, P., El-Sadr, W., Larson, E. 2002. Prevalence and antimicrobial patterns of Acinetobacter baumannii on hands and nares of hospital personnel and patients: the iceberg phenomenon again. Heart Lung. 31:382–390.PubMedCrossRefGoogle Scholar
  4. Bergogne-Berezin, E., Joly-Guillou, M.L., Towner, K.J. 1996. Acinetobacter, microbiology, epidemiology, infections, management. CRC Press, FL.Google Scholar
  5. Blot, S., Vandewoude, K., Colardyn, F. 2003. Nosocomial bacteremia involving Acinetobacter baumannii in critically ill patients; a matched cohort study. Int Care Med. 29:471–475.Google Scholar
  6. Carbonne, A., Naas, T., Blanckaert, K., Couzigou, C., Cattoen, C., Chagnon, J.L., Nordmann, P., Astagneau, P. 2005. Investigation of a nosocomial outbreak of extended-spectrum ß-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a hospital setting. J Hosp Infect. 60:14–18.PubMedCrossRefGoogle Scholar
  7. Cardenosa Cendrero, J.A., Sole-Violan, J., Bordez Benitez, A., Noguera Catalan, J., Arroyo Fernandez, J., Saavedra Santana, P., Rodriguez de Castro F. 1999. Role of different routes of tracheal colonization in the development of pneumonia in patients receiving mechanical ventilation. Chest. 116:462–470.PubMedCrossRefGoogle Scholar
  8. Centers for Disease Control and Prevention (CDC). 2002–2004. Acinetobacter baumannii infections among patients at military medical facilities treating injured U.S. service members. MMWR Morb Mortal Wkly Rep. 53:1063–1066.Google Scholar
  9. Chastre, J. 2003. Infections due to Acinetobacter baumannii in the ICU. Semin Respir Crit Care Med. 24:69–78.PubMedCrossRefGoogle Scholar
  10. Chastre, J., Trouillet, J.L., Vuagnat, A., Joly-Guillou, M.L. 1996. Nosocomial pneumonia caused by Acinetobacter spp. In Bergogne-Berezin, E., Joly-Guillou, M.L., Towner, K.J. (eds.), Acinetobacter, Microbiology, Epidemiology, Infections, Management. Florida: CRC Press.Google Scholar
  11. Chen, S.F., Chang, W.W., Chuang, Y.C., Tsaï, H.H., Tsaï, N.W., Chang, H.W., Lee, P.Y., Chien, C.C., Huang, C.R., Young, T.G. 2005. Adult Acinetobacter meningitis and its comparison with non Acinetobacter Gram negative bacterial meningitis. ACTA neurol Taïwan. 14:131–137.PubMedGoogle Scholar
  12. Davis, K.A., Moran, K.A., McAllister, C.K., Gray, P.J. 2005. Multidrug-resistant Acinetobacter extremity infections in soldiers. Emerging Infect Dis. 11:1218–1224.PubMedGoogle Scholar
  13. Del Mar, C., Thomas, M., Cartelle, M., Pertega, S., Beceiro, A., Llinares, P., Canle, D., Molina, F., Villanueva, R., Cisneros, J.M., Bou, G. 2005. Hospital outbreak caused by a carbanepen-resistant strain of Acinetobacter baumannii: patient prognosis and risk-factors for colonisation and infection. Clin Microbiol Infect. 11:540–6.CrossRefGoogle Scholar
  14. Fagon, J.Y., Chastre, J., Domart, Y., Trouillet, J.L., Gibert, C. 1996. Mortality due to ventilator-associated pneumonia or colonization with Pseudomonas or Acinetobacter species. Assessment by quantitative culture of samples obtained by a protected specimen brush. Clin Infect Dis. 23:538–542.PubMedCrossRefGoogle Scholar
  15. Fierobe, L., Lucet, J.C., Decre, D., Muller-Seryies, C., Deleuze, A., Joly-Guillou, M.L., Mantz, J., Desmont, J.M. 2001. An outbreak of imipenem-resistant Acinetobacter baumannii in critically ill surgical patients. Infect Control Hosp Epidemiol. 22:35–40.PubMedCrossRefGoogle Scholar
  16. Gales, A.C., Sader, H.S., Jones, R.N. 2002. Respiratory tract pathogens isolated from patients hospitalized with suspected pneumonia in Latin America: frequency of occurrence and antimicrobial susceptibility profile: results from the SENTRY Antimicrobial Surveillance Program (1997–2000). Diagn Microbiol Infect Dis. 44:301–11.PubMedCrossRefGoogle Scholar
  17. Garnacho, J., Sole-Violan, J., Sa-Borges, M., Diaz, E., Rello, J. 2003. Clinical impact of pneumonia caused by Acinetobacter baumannii in intubated patient: a matched cohort study. Crit Care Med. 10:2478–2482.CrossRefGoogle Scholar
  18. Goel, V.K., Kapil, A. 2001. Monoclonal antibodies against the iron regulated outer membrane Proteins of Acinetobacter baumannii are bactericidal. BMC Microbiol. 1: 16–24PubMedCrossRefGoogle Scholar
  19. Gonzalez, R.H., Nusblat, A., Nudel, B.C. 2001. Detection and characterization of quorum sensing signal molecules in Acinetobacter strains. Microbiol Res. 155:271–277.PubMedCrossRefGoogle Scholar
  20. Jiang, J.H., Chiu, N.C., Huang, F.Y., Kao, H.A., Hsu, C.H., Hung, H.Y., Chang, J.H., Peng, C.C. 2004. Neonatal sepsis in the neonatal intensive care unit: characteristics of early versus late onset. J Microbiol Immunol Infect. 37:301–306.PubMedGoogle Scholar
  21. Kaul, R., Burt, J.A., Cork, L., Dedier, H., Garcia, M., Kennedy, C., Brunton Krajden, M., Conly, J. 1996. Investigation of a multiyear multiple critical care unit outbreak due to relatively drug-sensitive Acinetobacter baumannii: risk factors and attributable mortality. J Infect Dis. 174:1279–1287.PubMedCrossRefGoogle Scholar
  22. Kelkar, R., Gordon, S.M., Giri, N., Rao, K., Ramakrishnan, G., Saikia, T., Nair, C.N., Kurkure, P.A., Pai, S.K., Jarvis, W.R. and Advani, S.H. 1989. Epidemic iatrogenic Acinetobacter spp. meningitis following administration of intrathecal methotrexate. J Hosp Infect. 14: 233–243Google Scholar
  23. Koeleman, J.G.M., Van Der Bijl, M.W., Stoof, J., Vanderbroucke-Grauls, C.M.J.E., Savelkoul, P.H.M. 2001. Antibiotic resistance is a major risk factor for epidemic behavior of Acinetobacter baumannii. Infect Control Hosp Epidemiol. 22:284–288.PubMedCrossRefGoogle Scholar
  24. La Scola, B., Fournier, P.E., Brouqui, P., Raoult, D. 2001. Detection and culture of Bartonella quintana, Serratia marscesens, and Acinetobacter spp. from decontaminted human body lice. J Clin Microbiol. 39:1707–1709.PubMedCrossRefGoogle Scholar
  25. Leung, W.S., Chu, C.M., Tsang, K.Y., Lo, F.H., Lo, K.F., Ho, P.L. 2006. Fulminant community acquired Acinetobacter baumannii pneumonia as a distinct clinical syndrome. Chest. 129: 102–109.PubMedCrossRefGoogle Scholar
  26. Livermore, D.M. 2003. The threat from the pink corner. Ann Med Int. 35:226–234.CrossRefGoogle Scholar
  27. Mah, M.W., Memish, Z.A., Cunningham, G., Bannatyne, R.M. 2001. Outbreak of Acinetobacter baumannii in an intensive care unit associated with tracheostomy. Am J Infect Control. 29:284–288.PubMedCrossRefGoogle Scholar
  28. McDonald, L.C., Banerjee, S.N., Jarvis, W.R. 1999. Seasonal variation of Acinetobacter infections: 1987–1996. Nosocomial Infections Surveillance System. Clin Infect Dis. 29:1133–1137.PubMedCrossRefGoogle Scholar
  29. Megarbane, B., Bruneel, F., Bedos, J.P., Wolff, M., Regnier, B. 2000. Acinetobacter baumannii community-acquired pneumonia in a patient with HIV infection. Presse Med. 29:788–789.PubMedGoogle Scholar
  30. Mehr, S.S., Sadowsky, J.L., Doyle, L.W., Carr, J. 2002. Sepsis in neonatal intensive care in the late 1990s. J Paediatr Child Health. 38:246–251.PubMedCrossRefGoogle Scholar
  31. Metan, G., Alp, E., Aygen, B., Sumerkan, B. 2007. Carbapenem-resistant Acinetobacter baumannii: an emerging threat for patients with post-neurosurgical meningitidis. Int J Antimicrob Agents. 29:112–116.PubMedCrossRefGoogle Scholar
  32. Mitchell, A.E., Siviz, L.B., Black, R.E. Editors. 2007. Gulf War and Health: Volume 5. Infectious Diseases. Washington DC: The National Academies Press.Google Scholar
  33. Obana, Y. 1986. Pathogenic significance of Acinetobacter calcoaceticus: analysis of experimental infection in mice. Microbiol Immunol. 30:645–657.PubMedGoogle Scholar
  34. Olut, A.I., Erkek, E. 2005. Early prosthetic valve endocarditis due to Acinetobacter baumannii: a case report and brief review of the literature. Scand J Infect Dis. 37:919–921.PubMedCrossRefGoogle Scholar
  35. Oncül, O., Keskin, O., Acar, H.V., Kucukardali, Y., Evrenkaya, R., Atasoyu, E.M., Top, C., Nalbant, S., Ozkan, S., Emekdas, G., Cavuslu, S., Us, M.H., Pahsa, A., Gokben, M. 2002. Hospital-acquired infections following the 1999 Marmara earthquake. J Hosp Infect. 51:47–51.PubMedCrossRefGoogle Scholar
  36. Poutanen, S.M., Louie, M., Simor, A.E. 1997. Risk factors, clinical features and outcome of Acinetobacter bacteremia in adults. Eur J Clin Microbiol Infect Dis. 16: 737–740.PubMedCrossRefGoogle Scholar
  37. Rathinavelu, S., Zavros, Y., Merchant, J.L. 2003. Acinetobacter lwoffii infection and gastritis. Microbes Infect. 5:651–657.PubMedCrossRefGoogle Scholar
  38. Rello, J. 1999. Acinetobacter baumannii infections in the ICU: customization is the key. Chest. 115:1226–1229.PubMedCrossRefGoogle Scholar
  39. Rello, J., Diaz, E. 2003. Acinetobacter baumannii: a threat for ICU. Intensive Care Med. 29:350–351.PubMedGoogle Scholar
  40. Salas Coronas, J., Cabezas Fernandez, T., Alvarez-Ossorio Garcia de Soria, R., Diez Garcia, F. 2003. Community-acquired Acinetobacter baumannii pneumonia. Rev Clin Esp. 203:284–286.Google Scholar
  41. Saulnier, F.F., Hubert, H., Onimus, T.M., Beague, S., Nseir, S., Grandbastien, B., Renault, C.Y., Idzik, M., Erb, M.P., Durocher, A.V. 2001. Assessing excess nurse work load generated by multi-resistant nosocomial bacteria in intensive care. Infect Control Hosp Epidemiol. 22:273–278.PubMedCrossRefGoogle Scholar
  42. Sherertz, R.J., Sullivan, M.L. 1985. An outbreak of infections with Acinetobacter calcoaceticus in burn patients: contamination of patients' mattresses. J Infect Dis. 151:252–258.PubMedCrossRefGoogle Scholar
  43. Simor, A.E., Lee, M., Vearncombe, M., Jones-Paul, L., Barry, C., Gomez, M., Fish, J.S., Cartotto, R.C., Palmer, R., Louie, M. 2002. An outbreak due to multi-resistant Acinetobacter baumannii in a burn unit: risk factors for acquisition and management. Infec Control Hosp Epidemiol. 23:261–267.CrossRefGoogle Scholar
  44. Smolyakov, R., Borer, A., Riesenberg, K., Schlaeffler, F., Alkan, M., Porath, A., Rimar, D., Almog, Y., Gilad, J. 2003. Nosocomial multi-drug resistant Acinetobacter baumannii bloodstream infection: risk factor and outcome with ampicillin-sulbactam treatment. J Hosp Infect. 54:32–38.PubMedCrossRefGoogle Scholar
  45. Starakis, I., Blikas, A., Siagris, D., Marangos, M., Karatza, C., Bassaris, H. 2006. Prosthetic valve endocarditis caused by Acinetobacter lwoffi: a case report and Review. Cardiol Rev. 14:45–49.PubMedCrossRefGoogle Scholar
  46. Theaker, C., Azadian, B., Soni, N. 2003. The impact of Acinetobacter baumannii in the intensive care unit. Anaesthesia. 58:271–274.PubMedCrossRefGoogle Scholar
  47. Tong, M.J. 1972. Septic complications of war wounds. JAMA. 219:1044–1047.PubMedCrossRefGoogle Scholar
  48. Valero, C., Farinas, M.C., Garcia Palomo, D., Mazarrasa, J.C., Gonzalèz Macias, J. 1999. Endocarditis due to Acinetobacter lwoffi on native mitral valve. Int J Cardiology. 69:37–99.CrossRefGoogle Scholar
  49. Valero, C., Garcia Palomo, J.D., Mattoras, P., Fernandez-Mazarrasa, C., Gonzales-Fernandez, C., Farinas, M.C. 2001. Acinetobacter bacteraemia in a teaching hospital, 1989–1998. Eur J Int Med. 12:425–429.CrossRefGoogle Scholar
  50. Vaque, J., Rossello, J., Arribas, J.L. 1999. Prevalence of nosocomial infections in Spain: EPINE study 1990–1997. EPINE Working Group. J Hosp Infect. 43:S105–S111.PubMedCrossRefGoogle Scholar
  51. Vincent, J.L., Bihari, D.J., Suter, P.M., Bruining, H.A., White, J., Nicholas-Chanoine, M.H. 1995. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of infection in intensive care (EPIC) study. EPIC International Advisory Committee. JAMA. 274:639–644.PubMedCrossRefGoogle Scholar
  52. Von Dolinger De Brito, D., Oliveira, E.J., Abdallah, V.O., Da Costa Darina, A.L., Filho, P.P. 2005. An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil. Braz J Infect Dis. 9:301–309.CrossRefGoogle Scholar
  53. Wagenvort, J.H.T., De Brauwer, E.I.G.B., Toenbreker, H.M.J., Van Der Linden, C.J. 2002. Epidemic Acinetobacter baumannii strain with MRSA-like behaviour carried by healthcare staff. Eur J Clin microbiol Infect Dis. 21:326–327.CrossRefGoogle Scholar
  54. Wang, J.T., McDonald, L.C., Chang, S.C., Ho, M. 2002. Community-acquired Acinetobacter baumannii bacteremia in adult patients in Taiwan. J Clin Microbiol. 40:1526–1529.PubMedCrossRefGoogle Scholar
  55. Wang, S.H., Sheng, W.H., Chang, Y.Y., Wang, L.H., Lin, H.C., Chen, M.L., Pan, H.J., Ko, W.J., Chang, S.C., Lin, F.Y. 2003. Healthcare-associated outbreak due to pan-drug resistant Acinetobacter baumannii in a surgical intensive care unit. J Hosp Infect. 53:97–102.PubMedCrossRefGoogle Scholar
  56. Wisplinghoff, H., Edmond, M.B., Pfaller, M.A., Jones, R.N., Wenzel, R.P., Seifert, H. 2000. Nosocomial blood stream infections caused by Acinetobacter species in United States Hospitals: Clinical features, molecular epidemiology, and antimicrobial susceptibility. Clin Infect Dis. 31:690–697.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • M. L. Joly-Guillou
    • 1
  1. 1.Microbiology DepartmentMedical UniversityAngersFrance

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