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Acinetobacter baumannii: Mechanisms of Resistance, Multiple ß-Lactamases

  • Laurent Poirel
  • Patrice Nordmann
Chapter
Part of the Infectious Agents and Pathogenesis book series (IAPA)

Naturally encoded ß-Lactamases in Acinetobacter baumannii

Acinetobacter baumannii produces naturally an AmpC-type cephalosporinase, normally expressed at a basal level, which does not reduce the efficacy of expanded-spectrum cephalosporins (Bou and Martinez-Beltran, 2000). The AmpC variants identified from A. baumannii strains have been named ADC-type (Acinetobacter derived cephalosporinase) enzymes (Hujer et al., 2005). They hydrolyze amino-penicillins and first-, second- and third-generation cephalosporins; they do not confer resistance to ceftazidime when the corresponding gene is expressed at a basal level. However, insertion of a specific insertion sequence element ISAba1 (belonging to the IS4 family) upstream of the blaampC gene enhances the expression of this AmpC ß-lactamase by providing promoter sequences, resulting in resistance to ceftazidime but sparing carbapenems (Corvec et al., 2003; Segal et al., 2004; Héritier et al., 2006c). A. baumanniiproduces another naturally...

Keywords

Acinetobacter Baumannii ESBL Producer Carbapenem Resistance ESBL Gene Baumannii Isolate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Laurent Poirel
    • 1
  • Patrice Nordmann
    • 1
  1. 1.Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de ParisUniversité Paris XIFrance

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