TGF-Beta and Regulatory T Cells

  • Yisong Y. Wan
  • Richard A. Flavell


Suppression of the immune system is critical in maintaining self-tolerance and immune homeostasis. Multiple types of cytokines and cell types actively suppress immune responses. Among them, the pleiotropic cytokine TGF-β, and naturally occurring regulatory T cells (Treg) are the best characterized. Dysregulation of either one leads to various immunopathologies under physiological conditions, demonstrating their essential roles in immune suppression. In addition, therapeutic strategies to treat aberrations of immune function by manipulating TGF-β and Treg functions have shown promising results. In this chapter, we will discuss the biologic functions of TGF-β and Treg, and the potential therapeutic effects on immune-related diseases through the manipulation of TGF-β and Treg function.


Treg Cell Immune Suppression Foxp3 Expression Neonatal Diabetes Mellitus Scurfy Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The research performed in our laboratory mentioned in this book chapter is supported by the NIH, American Diabetes Association (ADA) and Howard Hughes Medical Institute. R.A.F. is an investigator of the Howard Hughes Medical Institute. Y.Y.W. is supported by a postdoctoral fellowship from Cancer Research Institute (CRI). We are grateful to S. Wrzesinski for the critical reading of this manuscript and helpful comments. We thank F. Manzo for secretarial assistance.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Section of ImmunobiologyYale University School of Medicine; Howard Hughes Medical InstituteNew HavenUSA

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