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IL-2 Signaling and CD4+ CD25+ Regulatory T Cells

  • Louise M. D’Cruz
  • Ludger Klein
Chapter

Abstract

Over the last two decades, our understanding of the function of Interleukin-2 (IL-2) has experienced several paradigmatic shifts. Although IL-2 was initially identified as a T cell growth factor, loss of function experiments clearly showed that it rather acts as a gatekeeper of immune homeostasis and tolerance. It is now widely accepted that the major non-redundant function of IL-2 is the maintenance of naturally occurring CD25+ Foxp3+ regulatory T cells (Treg). Importantly, this role as an essential survival factor may blur the interpretation of loss-of-function studies that tried to address other, mutually not exclusive functions of IL-2 in Treg biology, such as development and function. This chapter will summarize our current understanding of how IL-2 signaling may relate to these aspects of immune regulation by Treg.

Keywords

Experimental Autoimmune Encephalomyelitis Immune Homeostasis Activation Induce Cell Death Responder Cell Treg Induction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Institute for ImmunologyLudwig-Maximilians-University MunichGoethestrasse 31Germany

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