Natural Killer T Cells Regulate the Development of Asthma

  • Muriel Pichavant
  • Rosemarie H. DeKruyff
  • Dale T. Umetsu


NKT cells play an important role at the interface between innate and acquired immunity, because of their rapid production of Th1 as well as Th2 cytokines upon activation, and their expression of germline encoded T cell receptors. In addition, NKT cells critically regulate the development of airway hypeerreactivity (AHR), a cardinal feature of asthma, by producing IL-4 and IL-13, and by interacting with T cells and inducing Th2 cell production of IL-4 and IL-13. NKT cells thus play an important proinflammatory role in asthma, in contrast to suppressive CD4+ CD25+ natural and adaptive regulatory T cells, which inhibit airway inflammation and AHR.


Experimental Autoimmune Encephalomyelitis TReg Cell Primary Biliary Cirrhosis Allergic Asthma iNKT Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Muriel Pichavant
  • Rosemarie H. DeKruyff
  • Dale T. Umetsu
    • 1
  1. 1.Karp Laboratories, Division of Immunology and AllergyChildren’s Hospital, Harvard Medical School, Harvard UniversityBostonUSA

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