Innate Regulatory iNKT Cells

  • Dalam Ly
  • Terry L. Delovitch


The complexity of the immune system requires mechanisms, cellular and molecular, that coordinate early innate immune responses to those of late adaptive immune responses. One type of immune cell that is able to mediate this bridge between innate immunity and adaptive immunity is the invariant natural killer T (iNKT) cell. In recent years, much research has been focused on describing the role of iNKT cells in a variety of immune responses, from pathogen clearance, cancer immunity, to autoimmune regulation. In each of these immune conditions, iNKT cells have been shown to play direct or indirect roles in the coordinating immune responses leading to downstream effector activation. In this review, we highlight our current understanding of iNKT cell biology, and provide an overview of iNKT cell antigen specificities and of the role of iNKT cells in regulating immune responses.


Natural Killer Cell Cerebral Malaria iNKT Cell Borrelia Burgdorferi Experimental Autoimmune Encephalomyelitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Laboratory of Autoimmune Diabetes, Robarts Research Institute; Department of Microbiology and ImmunologyUniversity of Western Ontario; FOCIS Centre for Clinical Immunology and ImmunotherapeuticsLondonCanada

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