Immune Suppression by a Novel Population of CD8ββ+TCRββ+ Regulatory T cells

  • Trevor R.F. Smith
  • Vipin Kumar


Peripheral tolerance mechanisms involve CD4+CD25+FoxP3+ as well as CD8+ Treg populations, each operating in a distinct manner. Here we have focused on immune suppression mediated by a novel population of CD8αα+TCRαβ+ Treg that target only activated T cells. These Treg are reactive to a peptide derived from the conserved region of the beta chain of the T cell receptor (TCR) utilized by pathogenic T cells and are restricted by a class Ib MHC molecule, Qa-1. Upregulation of Qa-1 on activated T cells for a limited time provides a window of opportunity for the suppression to occur. Furthermore expansion of CD8αα+TCRαβ+ Treg is dependent upon the provision of IL-2 externally and upon activation of dendritic cells. This brief review summarizes some of the important features of CD8αα+TCRαβ+ Treg and highlights their importance in the negative feedback regulation of the immune response.


Experimental Autoimmune Encephalomyelitis Treg Cell Treg Population Fetal Thymic Organ Culture Peripheral Tolerance Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Laboratory of AutoimmunityTorrey Pines Institute for Molecular Studies, 3550 General Atomics CourtSan DiegoUSA

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