IL-10 and TGF-β-Producing Regulatory T Cells in Infection

  • P.J. Dunne
  • A.G. Rowan
  • J.M. Fletcher
  • Kingston H.G. Mills


Protective immunity against viruses, bacteria, parasites and fungi is mediated by innate and adaptive immune responses of the hosts. However, pathogens have developed strategies for subverting these responses and thereby establishing persistent or chronic infections. Furthermore, anti-pathogen effector immune responses must be tightly regulated to prevent collateral damage to host tissues. Regulatory T (Treg) cells that secrete the immunosuppressive cytokines IL-10 and /or TGF-β have been implicated in both processes, assisting the host to prevent immunopathology and helping the pathogen to evade protective immunity. This chapter discusses the induction of antigen-specific IL-10 and TGF-β-producing regulatory T cells during infection and gives some examples of their different roles in immunity to parasites, bacteria, viruses and fungi.


Human Immunodeficiency Virus Peripheral Blood Mononuclear Cell Treg Cell Infected Mouse Simian Immunodeficiency Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • P.J. Dunne
    • 1
  • A.G. Rowan
  • J.M. Fletcher
  • Kingston H.G. Mills
  1. 1.School of Biochemistry and ImmunologyTrinity College Dublin 2Ireland

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