Regulatory T Cells in Transplantation

  • Kathryn J Wood
  • Andrew Bushell
  • Manuela Carvalho-Gaspar
  • Gang Feng
  • Ross Francis
  • Nick Jones
  • Elaine Long
  • Shiqiao Luo
  • Ian Lyons
  • Satish Nadig
  • Birgit Sawitzki
  • Gregor Warnecke
  • Bin Wei
  • Joanna Więckiewicz


Clinical success in treating transplant rejection to date has been achieved primarily through the development increasingly potent immunosuppressive drugs to inhibit immune responses. These approaches require life-long treatment and suppress the entire immune system non-specifically exposing the patient to increased risks of cancer and infection. Even then long-term graft survival is not guaranteed. Evidence that regulatory T cells can control rejection and facilitate the development of specific unresponsiveness to alloantigens in vivo has been accumulating over many years. Understanding how the immune system is controlled by regulatory T cells when it responds to alloantigen and promoting the development of cells that can regulate immune responses holds the key to the development of more selective therapies that target only destructive immune responses while leaving the beneficial protective functions of the immune system intact.


Experimental Autoimmune Encephalomyelitis Allograft Rejection Tolerance Induction Transplant Model Acute Rejection Episode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Kathryn J Wood
    • 1
  • Andrew Bushell
  • Manuela Carvalho-Gaspar
  • Gang Feng
  • Ross Francis
  • Nick Jones
  • Elaine Long
  • Shiqiao Luo
  • Ian Lyons
  • Satish Nadig
  • Birgit Sawitzki
  • Gregor Warnecke
  • Bin Wei
  • Joanna Więckiewicz
  1. 1.Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe HospitalUniversity of OxfordUK

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