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CD4+CD25+ Regulatory T Cells and TGF-Beta in Mucosal Inflammation

  • M. Fantini
  • Markus F. Neurath
Chapter

Abstract

Transforming growth factor-beta (TGF-beta) is an anti-inflammatory cytokine which plays a key role in the maintenance of the immune system homeostasis. Indeed the abrogation of the TGF-beta signaling in immune cells leads to autoimmunity and inflammation in several organs including the gut. TGF-beta acts at multiple levels to maintain the immune system in check. However, TGF-beta has been recently shown to play a key role in the peripheral generation and function of CD4+CD25+ regulatory T cells, a subset of suppressive lymphocytes involved in the control of effector T cell activation and proliferation. Consistently abrogation of Tregs maturation as observed in different systems leads to a phenotype resembling that caused by the impairment of the TGF-beta signaling thus linking Tregs and TGF-beta activities. Here we review data generated in the last years at support of this link.

Keywords

Adoptive Transfer Mucosal Inflammation Mucosal Immune System Smad7 Expression FoxP3 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • M. Fantini
  • Markus F. Neurath
    • 1
  1. 1.Laboratoty of Mucosal ImmunologyJohannes Gutenberg University of MainzGermany

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