Natural CD4+CD25+ Regulatory T Cells in Regulation of Autoimmune Disease



An essential characteristic of thymic T cell development is the generation of TCR diversity enabling T cells to respond to an unlimited number of foreign antigens. However, one inevitable consequence of TCR diversity is the generation of self-reactive TCRs creating the potential for autoimmune disease. To balance this, the immune system has developed the processes of central and peripheral tolerance to deter the generation of self-reactive T cells as well as to regulate the function of autoreactive T cells that persist in the mature T cell repertoire, respectively. We’ll discuss here one critical mediator of peripheral tolerance, CD4+CD25+ regulatory or suppressor T cells, and their role in regulating the various processes of autoimmune disease.


Multiple Sclerosis Rheumatoid Arthritis Patient Central Tolerance Cell Effector Function Regulatory Cell Population 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of Microbiology-Immunology and Interdepartmental Immunobiology CenterFeinberg School of Medicine, Northwestern UniversityChicagoUSA

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