Postoperative Care of the Cardiac Surgical Patient

  • Ross F. DiMarcoJr.


The subspecialty of interventional cardiology began in 1977. Since then, the discipline of interventional cardiology has matured rapidly, particularly with regards to ischemic heart disease. As a result, more patients are undergoing percutaneous catheter interventional therapy for ischemic heart disease and fewer patients are undergoing surgical myocardial revascularization. Those patients referred for surgical revascularization are generally older and have more complex problems. Furthermore, as the population ages more patients are referred to surgery for valvular heart disease. The result of these changes is a population of surgical patients older and sicker than previously treated.


Atrial Fibrillation Cardiac Output Cardiopulmonary Bypass Right Ventricle Pulmonary Capillary Wedge Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Cameron D. Initiation of white cell activation during cardiopulmonary bypass: cytokines and receptors. J Cardiovasc Pharmacol. 1996;27(Suppl 1):S1.PubMedCrossRefGoogle Scholar
  2. 2.
    Chu SH, Huang TS, Hsu RB, et al. Thyroid hormone changes after cardiovascular surgery and clinical implications. Ann Thorac Surg. 1991;52:791.PubMedCrossRefGoogle Scholar
  3. 3.
    Tulla H, Takala J, Alhava E, et al. Hypermetabolism after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1991;101:598.PubMedGoogle Scholar
  4. 4.
    Chiara O, Giomarelli PP, Biagioli B, et al. Hypermetabolic response after hypothermic cardiopulmonary bypass. Crit Care Med. 1987;15:995.PubMedCrossRefGoogle Scholar
  5. 5.
    Crock PA, Ley CJ, Martin IK, et al. Hormonal and metabolic changes during hypothermic coronary artery bypass surgery in diabetic and non-diabetic subjects. Diabet Med. 1988;5:47.PubMedCrossRefGoogle Scholar
  6. 6.
    Westaby S. Organ dysfunction after cardiopulmonary bypass. A systemic inflammatory reaction initiated by the extracorporeal circuit. Intensive Care Med. 1987;13:89.PubMedCrossRefGoogle Scholar
  7. 7.
    Chenoweth DE, Cooper SW, Hugli TE, et al. Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins. N Eng J Med. 1981;304:497.CrossRefGoogle Scholar
  8. 8.
    Moore FD, Warner KG, Assousa S, et al. The effects of complement activation during cardiopulmonary bypass. Attenuation by hypothermia, heparin, and hem dilution. Ann Surg. 1988;208:95.PubMedCrossRefGoogle Scholar
  9. 9.
    Dinarello CA. Interleukin-1 and the pathogenesis of the acute phase response. N Eng J Med. 1984;311:1413.CrossRefGoogle Scholar
  10. 10.
    McCord JM, Wong K, Stokes SH, et al. Superoxide and inflammation: a mechanism for the anti-inflammatory activity of superoxide dismutase. Acta Physiol Scand Suppl. 1980;492:25.PubMedGoogle Scholar
  11. 11.
    Jastrzebski J, Sykes MK, Woods DG. Cardiorespiratory effects of protamine after cardiopulmonary bypass in man. Thorax. 1974;29:534.PubMedCrossRefGoogle Scholar
  12. 12.
    Klausner JM, Morel N, Paterson IS, et al. The rapid induction by interleukin-2 of pulmonary microvascular permeability. Ann Surg. 1989;209:119.PubMedCrossRefGoogle Scholar
  13. 13.
    Gold JP, Roberts AJ, Hoover EL, et al. Effects of prolonged aortic cross clamping with potassium cardioplegia on myocardial contractility in man. Surg Forum. 1979;30:252.PubMedGoogle Scholar
  14. 14.
    Sladen RV, Berkowitz DE. In: Gravlee, GP, Gavis RF, Uhey DR, editors. Cardiopulmonary bypass and the lung. 1st ed. Baltimore, MD: Williams & Willkins; 1993.Google Scholar
  15. 15.
    Bolli R. Oxygen derived free radical and postischemic myocardial dysfunction. J Am Coll Cardiol. 1988;12:239.PubMedCrossRefGoogle Scholar
  16. 16.
    Przyklenk K, Kloner RA. “Reperfusion injury” by oxygen derived free radicals? Circ Res. 1989;64:86.PubMedCrossRefGoogle Scholar
  17. 17.
    Spiess BD. Ischemia-a coagulation problem? J Cardiovasc Pharmacol. 1996;27(Suppl 1):538.Google Scholar
  18. 18.
    Breisblatt WM, Stein KI, Wolfe CJ, et al. Acute myocardial dysfunction and recovery: a common occurrence after coronary bypass surgery. J Am Coll Cardiol. 1990;15:1261.PubMedCrossRefGoogle Scholar
  19. 19.
    Mack MJ. Beating heart surgery: does it make a difference? Am Heart Hosp J. 2003;76:1510.Google Scholar
  20. 20.
    Morris DC, St Claire D. Management of patients after cardiac surgery. Curr Probl Card. 1999;24:161.Google Scholar
  21. 21.
    Milano CA, Smith PK. Critical care for the adult cardiac patient. Sabiston & Spencer surgery of the chest. 7th ed. Philadelphia: Elsevier Saunders; 2005.Google Scholar
  22. 22.
    Bojar RM. Manual of perioperative care in cardiac and thoracic surgery. 4th ed. Boston: Blackwell; 2005.CrossRefGoogle Scholar
  23. 23.
    Braunwald AG. Cardiac catheterization. In: Grossman W, editor. Heart disease. Philadelphia: WB Saunders; 1992. p. 180.Google Scholar
  24. 24.
    Applebaum A, Kouchoukos NT, Blackstone EH, Kirklin JW. Early risks of open heart surgery for mitral valve disease. Am J Cardiol. 1976;37:201.CrossRefGoogle Scholar
  25. 25.
    Kirklin JK, Kirklin JW. Management of the cardiovascular subsystem after cardiac surgery. Ann Thorac Surg. 1981;32:311.PubMedCrossRefGoogle Scholar
  26. 26.
    Kotter GS, Kortly KJ, Kalbfleisch JH, et al. Myocardial ischemia during cardiovascular surgery as detected by an ST segment trend monitoring system. J Cardiothorac Anesth. 1987;1:190.PubMedCrossRefGoogle Scholar
  27. 27.
    Yin FC. Ventricular wall stress. Circ Res. 1981;49:829.PubMedCrossRefGoogle Scholar
  28. 28.
    Johnson RG, Thurer RL, Kruskallm MS, et al. Comparison of two transfusion strategies after elective operations for myocardial revascularization. J Thorac Cardiovasc Surg. 1992;104:307–314.PubMedGoogle Scholar
  29. 29.
    Doak GJ, Hall RI. Does hemoglobin affect perioperative myocardial lactate flux in patients undergoing coronary artery bypass surgery? Anesth Analg. 1995;80:910–916.PubMedGoogle Scholar
  30. 30.
    Ardehali A, Ports TA. Myocardial oxygen supply and demand. Chest. 1990;98:699–705.PubMedCrossRefGoogle Scholar
  31. 31.
    Bojar RM, 2. Manual of perioperative care in cardiac and thoracic surgery. 2nd ed. Boston: Blackwell; 1994.Google Scholar
  32. 32.
    Pryzklenk K, Kloner RA. “Reperfusion injury” by oxygen free radicals? Circ Res. 1989;64:86.CrossRefGoogle Scholar
  33. 33.
    Bachman F, McKenna R, Cole ER, Najafi H. The hemostatic mechanism after open-heart surgery. I. Studies on plasma coagulation factors and fibrinolysis in 512 patients after extracorporeal circulation. J Thorac Cardiovasc Surg. 1975;70(1):76–85.Google Scholar
  34. 34.
    Royster RL, Butterworth JF, Prough DS, et al. Preoperative and intraoperative predictors of inotropic support and long-term outcomes in patients having coronary artery bypass grafting. Anesth Analg. 1991;72:729–736.PubMedCrossRefGoogle Scholar
  35. 35.
    Bernard F, Denault A, Babin D, et al. Diastolic dysfunction is predictive of difficult weaning of from cardiopulmonary bypass. Anesth Analg. 2001;92:291–298.PubMedCrossRefGoogle Scholar
  36. 36.
    Aurigemma G, Battista S, Orsinelli D, et al. Abnormal left ventricular intracavitary flow acceleration in patients undergoing aortic valve replacement for aortic stenosis. A marker for high postoperative morbidity and mortality. Circulation. 1992;86:926.PubMedCrossRefGoogle Scholar
  37. 37.
    Bartunek J, Sys Su, Rodrigues AC, et al. Abnormal systolic intracavity velocities after valve replacement for aortic stenosis. Mechanisms, predictive factors, and prognostic significance. Circulation. 1996;93:712.PubMedCrossRefGoogle Scholar
  38. 38.
    Kirklin JW, Barratt-Boyes G. Cardiac surgery. 2nd ed. New York: Churchill Livingstone; 1993.Google Scholar
  39. 39.
    Aral A, Oguz M, Ozberrak H, et al. Hemodynamic advantage to left atrial epinephrine administration in open heart surgery. Ann Thorac Surg. 1997;64:1046.PubMedCrossRefGoogle Scholar
  40. 40.
    Lassnigg A, Donner E, Grubhofer G, et al. Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. J Am Soc Neourol. 2000;11:97.Google Scholar
  41. 41.
    Woo EB, Tang AT, el-Gamel A, et al. Dopamine therapy for patients at risk of renal dysfunction following cardiac surgery: fact or fiction? Eur J Cardiothorac Surg. 2002;22:106.PubMedCrossRefGoogle Scholar
  42. 42.
    Fowler MB, Alderman EL, Oesterle SN, et al. Dobutamine and dopamine after cardiac surgery: greater augmentation of myocardial blood flow with dobutamine. Circulation. 1984;70(suppl I):I103.PubMedGoogle Scholar
  43. 43.
    Romson JL, Leung JM, Bellows WH, et al. Effects of dobutamine on hemodynamic and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients. Anesthesiology. 1999;91:1318.PubMedCrossRefGoogle Scholar
  44. 44.
    Van Trigt P, Spray TL, Pasque MK, Peyton RB, Pellom GL, Wechsler AS. The comparative effects of dopamine and dobutamine on ventricular mechanics after coronary artery grafting: a pressure-dimension analysis. Circulation. 1984;70(suppl I):112.Google Scholar
  45. 45.
    DiSesa VJ, Brown E, Mudge GH Jr, et al. Hemodynamic comparison of dopamine and dobutamine in the postoperative volume-loaded, pressure-loaded, and normal ventricle. J Thorac Cardiovasc Surg. 1982;83:256.PubMedGoogle Scholar
  46. 46.
    Butterworth JF IV. Use of amrinone in cardiac surgery patients. J Cardiothorac Vasc Anesth. 1993;7:1.PubMedCrossRefGoogle Scholar
  47. 47.
    Ko W, Zelano JA, Fahey AL, et al. The effects of amrinone versus dobutamine on myocardial mechanics after hypothermic global ischemia. J Thorac Cardiovasc Surg. 1993;105:1015.PubMedGoogle Scholar
  48. 48.
    Royster RL, Butterworth JF IV, Prielipp RC, et al. A randomized, blinded trial of amrinone, epinephrine, and amrinone/epinephrine after cardiopulmonary bypass (CPB). Anesthesiology. 1991;75:A148.CrossRefGoogle Scholar
  49. 49.
    Olsen KH, Kluger J, Fieldman A. Combination high dose amrinone and dopamine in the management of moribund cardiogenic shock after open heart surgery. Chest. 1988;94:503.PubMedCrossRefGoogle Scholar
  50. 50.
    Royster RL, Butterworth JF IV, Prielipp RC, et al. Combined inotropic effects of amrinone and epinephrine after cardiopulmonary bypass in humans. Anesth Analg. 1993;77:662.PubMedCrossRefGoogle Scholar
  51. 51.
    Alousi AA, Johnson DC. Pharmacology of bipyridines: amrinone and milrinone. Circulation. 1986;73:III10.PubMedGoogle Scholar
  52. 52.
    Kikura M, Levy JH, Michelsen LG, et al. The effect of milrinone on hemodynamics and left ventricular function after emergence from cardiopulmonary bypass. Anesth Analg. 1997;85(1):16.PubMedGoogle Scholar
  53. 53.
    Lobato EB, Florete O Jr, Bingham HL. A single dose of milrinone facilitates separation from cardiopulmonary bypass in patients with pre-existing left ventricular dysfunction. Br J Anaesth. 1998;81(5):782.PubMedCrossRefGoogle Scholar
  54. 54.
    Liu JJ, Doolan LA, Xie B, et al. Direct vasodilator effect of milrinone, an inotropic drug, on arterial coronary bypass grafts. J Thorac Cardiovasc Surg. 1997;113(1):108.PubMedCrossRefGoogle Scholar
  55. 55.
    He GW, Yang CQ. Vasorelaxant effect of the phosphodiesterase-inhibitor milrinone in the human radial artery used as coronary bypass graft. J Thorac Cardiovasc Surg. 2000;119(5):1039.PubMedCrossRefGoogle Scholar
  56. 56.
    Gold JA, Cullinane S, Chen J, et al. Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension. Crit Care Med. 2000;28(1):249.PubMedCrossRefGoogle Scholar
  57. 57.
    Kikura M, Lee MK, Safon RA, et al. The effects of milrinone on platelets in patients undergoing cardiac surgery. Anesth Analg. 1995;81:44.PubMedGoogle Scholar
  58. 58.
    Camara ML, Aris A, Alvarez J, et al. Hemodynamic effects of prostaglandin E1 and isoproterenol early after cardiac operations for mitral stenosis. J Thorac Cardiovasc Surg. 1992;103:1177.PubMedGoogle Scholar
  59. 59.
    Product inserts. Natrecor (nesiritide), revised April 2005. (accessed 2006 Oct 30).
  60. 60.
    Blais D. Nesiritide compared with milrinone for cardiac surgery. Ann Pharmacother. 2007;41:502–504.PubMedCrossRefGoogle Scholar
  61. 61.
    Brackbill ML, Stam MD, Schuller-Williams RV, et al. Perioperative nesiritide versus milrinone in high-risk coronary artery bypass patients. Ann Pharmacother. 2007;41:427–432.PubMedCrossRefGoogle Scholar
  62. 62.
    Hebler RF Jr, Oz MC. Effect of perioperative nesiritide administration on postoperative renal function and clinical outcomes in patients undergoing cardiothoracic surgery (poster 104, abstract 292). Presented at: 7th Scientific Forum for Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke, Washington, DC, May 9, 2006.Google Scholar
  63. 63.
    Dunser MW, Mayr AJ, Ulmer H, et al. Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study. Circulation. 2003;107:2313.PubMedCrossRefGoogle Scholar
  64. 64.
    Den Ouden DT, Meinders AE. Vasopressin: physiology and clinical use in patients with vasodilatory shock: a review. Neth J Med. 2005;63(1):4–13.Google Scholar
  65. 65.
    Mutu GM, Factor P. Role of vasopressin in the management of septic shock. Intensive Care Med. 2004;30(7):1276–1291.Google Scholar
  66. 66.
    Landry DW, Levin HR, Gallant EM, et al. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation. 1997;95:1122.PubMedCrossRefGoogle Scholar
  67. 67.
    Holmes CL, Walley KR. Vasopressin in the ICU. Curr Opin Crit Care. 2004;6:442.CrossRefGoogle Scholar
  68. 68.
    Mekontso-Dessap A, Houel R, Soutelle C, et al. Risk factors for post-cardiopulmonary bypass vasoplegia in patients with preserved left ventricular function. Ann Thorac Surg. 2001;71:1428.PubMedCrossRefGoogle Scholar
  69. 69.
    Gomes WJ, Carvalho AC, Palma JH, et al. Vasoplegic syndrome after open heart surgery. J Cardiovasc Surg (Torino). 1998;39:619.Google Scholar
  70. 70.
    Mets B, Michler RE, Delphin ED, et al. Refractory vasodilatation after cardiopulmonary bypass for heart transplantation in recipients on combined amiodarone and angiotensin-converting enzyme inhibitor therapy: a role for vasopressin administration. J Cardiothorac Vasc Anesth. 1998;12:326.PubMedCrossRefGoogle Scholar
  71. 71.
    Morales DLS, Gregg D, Helman DN, et al. Arginine vasopressin in the treatment of 50 patients with postcardiotomy vasodilatory shock. Ann Thorac Surg. 2000;69:102–106.PubMedCrossRefGoogle Scholar
  72. 72.
    Hall LG, Oyen LJ, Taner CB, et al. Fixed-dose vasopressin compared with titrated dopamine and norepinephrine as initial vasopressor therapy for septic shock. Pharmacotherapy. 2004;8:1002.CrossRefGoogle Scholar
  73. 73.
    Linder KH, Dirks B, Strohmenger HU, et al. Randomized comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation. Lancet. 1997;349:535.CrossRefGoogle Scholar
  74. 74.
    O’Brien A, Clapp L, Singer M, et al. Terlipressin for norepinephrine-resistance septic shock. Lancet. 2002;359:1209.PubMedCrossRefGoogle Scholar
  75. 75.
    Dellinger RP, Carlet JM, et al. Surviving Sepsis Campaign for management of severe sepsis and septic shock. Crit Care Med. 2004;32:858.PubMedCrossRefGoogle Scholar
  76. 76.
    Drop LJ. Iononized calcium, the heart, and hemodynamic function. Anesth Anal. 1985;64:432.CrossRefGoogle Scholar
  77. 77.
    Holland FW, Brown PS Jr, Weintraub BD, et al. Cardiopulmonary bypass and thyroid function: a “euthyroid sick syndrome”. Ann Thorac Surg. 1991;52:46.PubMedCrossRefGoogle Scholar
  78. 78.
    Klemperer JD, Klein I, Gomez M, et al. Thyroid hormone treatment after coronary-artery bypass surgery. N Eng J Med. 1995;333:1522.CrossRefGoogle Scholar
  79. 79.
    Novitzky D, Cooper DKC, Swanepoel A. Inotropic effect of triiodothyronine in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: an initial experience in patients undergoing open-heart surgery. Eur J Cardiothorac Surg. 1989;3:140.PubMedCrossRefGoogle Scholar
  80. 80.
    Novitzky D, Cooper DKC, Barton CI, et al. Triiodothyronine as an inotropic agent after open-heart surgery. J Thorac Cardiovasc Surg. 1989;98:972.PubMedGoogle Scholar
  81. 81.
    Klemperer JD, Klein I, Gomez M, et al. Thyroid hormone treatment after coronary artery bypass surgery. N Engl J Med. 1995;333:1522.PubMedCrossRefGoogle Scholar
  82. 82.
    Davis PJ, Davis FB. Acute cellular actions of thyroid hormone and myocardial function. Ann Thorac Surg. 1993;56:S16.PubMedCrossRefGoogle Scholar
  83. 83.
    Vavouranakis I, Sanoudos G, Manios A, et al. Triiodothyronine administration in coronary artery bypass surgery: effect on hemodynamics. J Cardiovasc Surg (Torino). 1994;35:383.Google Scholar
  84. 84.
    Mullis-Jansson S, Corwin SJ, Delphin E, et al. A double blind placebo controlled study of the effect of triiodothyronine upon cardiac performance and outcome following coronary bypass surgery. Circulation. 1996;94(suppl I):1–171.Google Scholar
  85. 85.
    Kantrowicz A, Tjonneland S, Freed PS, et al. Initial clinical experience with intraaortic pumping for cardiogenic shock. JAMA. 1968;203:113.CrossRefGoogle Scholar
  86. 86.
    Maccioli GA, Lucas WJ, Norfleet EA. The intraaortic balloon pump: a review. J Cardiothorac Anesth. 1988;2:365.PubMedCrossRefGoogle Scholar
  87. 87.
    Khir AW, Price S, Heinein MY, et al. Intra-aortic balloon pumping: effects of left ventricular diastolic function. Eur J Cardiothorac Surg. 2003;24:277.PubMedCrossRefGoogle Scholar
  88. 88.
    Creswell LL, Rosenbloom M, Cox JL, et al. Intraaortic balloon counterpulsation: patterns of usage and outcome in cardiac surgery patients. Ann Thorac Surg. 1992;54:11.PubMedCrossRefGoogle Scholar
  89. 89.
    Naunheim KS, Swartz MT, Pennington DG, et al. Intraaortic balloon pumping in patients requiring cardiac operations. Risk analysis and long-term follow-up. J Thorac Cardiovasc Surg. 1992;104:654.Google Scholar
  90. 90.
    Goldberg MJ, Ruabenfire M, Kantowitz A, et al. Intraaortic balloon pump insertion: a randomized study comparing percutaneous and surgical techniques. J Am Coll Cardiol. 1987;9:515.PubMedCrossRefGoogle Scholar
  91. 91.
    Kirklin JW, Barratt-Boyes G. Cardiac surgery. 3rd ed. New York: Churchill Livingstone; 2003.Google Scholar
  92. 92.
    Swartz MT, Sakawato T, Arai H, et al. Effects of intraaortic balloon position on renal artery blood flow. Ann Thorac Surg. 1992;53:604–610.PubMedCrossRefGoogle Scholar
  93. 93.
    Rodigas PC, Bridges KG. Occlusion of left internal mammary artery with intraaortic balloon: clinical implications. J Thorac Cardiovasc Surg. 1986;01:142.Google Scholar
  94. 94.
    Cooley DA, Liotta D, Hallman GL, et al. Orthotopic cardiac prosthesis for two-staged cardiac replacement. Am J Cardiol. 1969;24:723.PubMedCrossRefGoogle Scholar
  95. 95.
    Pennington DG, editor. Mechanical circulatory support. Semin Thorac Cardiovasc Surg 1994;6:129–194.Google Scholar
  96. 96.
    Argenziano M, Oz MC, Rose EA. The continuing evolution of mechanical ventricular support. Curr Probl Surg. 1997;34:318.CrossRefGoogle Scholar
  97. 97.
    Oz MC, Rose EA, Levin HR. Selection criteria for placement of left ventricular assist devices. Am Heart J. 1995;129:173.PubMedCrossRefGoogle Scholar
  98. 98.
    Schmid C, Welp H, Klotz S, et al. Outcome of patients surviving to heart transplantation after being mechanically bridged for more than 100 days. J Heart Lung Transplant. 2003;22:1054.PubMedCrossRefGoogle Scholar
  99. 99.
    Chen JM, Levin HR, Rose EA, et al. Experience with right ventricular assist devices for perioperative right-sided circulatory failure. Ann Thorac Surg. 1996;61:305–310.PubMedCrossRefGoogle Scholar
  100. 100.
    Park CH, Nishimura K, Kitano M, et al. Analysis of right ventricular function during bypass of the left side of the heart by afterload alterations in both normal and failing hearts. J Cardiovasc Thorac Surg. 1996;111:1092–1102.CrossRefGoogle Scholar
  101. 101.
    Mooney MR, Arom KV, Joyce LD, et al. Emergency ­cardiopulmonary bypass support in patients with cardiac arrest. J Thorac Cardiovasc Surg. 1991;101:450.PubMedGoogle Scholar
  102. 102.
    Phillips SJ, Zeff RH, Kongtahworn C, et al. Percutaneous cardiopulmonary bypass: application and indication for use. Ann Thorac Surg. 1989;47:21.Google Scholar
  103. 103.
    Pego-Fernandes PM, Stolf NAG, Moreira LFP, et al. Influence of Biopump with and without intraaortic balloon pump on the coronary and carotid flow. Ann Thorac Surg. 2000;69:536.PubMedCrossRefGoogle Scholar
  104. 104.
    Chen YS, Chao A, Yu HY, et al. An analysis and results of prolonged resuscitation in cardiac arrest patients by extracorporeal membrane oxygenation. J Am Coll Cardiol. 2003;41:197.PubMedCrossRefGoogle Scholar
  105. 105.
    Smedira NG, Moazami N, Golding CM, et al. Clinical experience with 202 adults receiving extracorporeal membrane oxygenation for cardiac failure: survival at 5 years. J Thorac Cardiovasc Surg. 2001;122:92.PubMedCrossRefGoogle Scholar
  106. 106.
    Smedira NG, Blackstone EH. Postcardiotomy mechanical support: risk factors and outcomes. Ann Thorac Surg. 2001;72:S60.CrossRefGoogle Scholar
  107. 107.
    Frazier OH. Left ventricular assist. In: Karp RB, Laks H, Wechsler, A, editors. Advances in cardiac surgery. 1997. vol. 9, p. 131.Google Scholar
  108. 108.
    Wallach R, Karp RB, Reves JG, et al. Pathogenesis of paroxysmal hypertension developing during and after coronary bypass surgery: s study of hemodynamic and humoral factors. Am J Cardiol. 1980;46:559.PubMedCrossRefGoogle Scholar
  109. 109.
    Roberts AJ, Niarchos AP, Subarmanian VA, et al. Systemic Hypertension associated with coronary artery bypass surgery. J Thorac Cardiovasc Surg. 1977;74:846.PubMedGoogle Scholar
  110. 110.
    Kaplan JA, Guffin AV. Perioperative management of hypertension and tachycardia. J Cardiothorac Anesth. 1990;4:7.CrossRefGoogle Scholar
  111. 111.
    Fremes SE, Weisel RD, Baird RJ, et al. Effects of postoperative hypertension and its treatment. J Thorac Cardiovasc Surg. 1983;86:47.PubMedGoogle Scholar
  112. 112.
    Palmer RF, Lasseter KC. Drug therapy: sodium nitroprusside. N Engl J Med. 1975;292:294.PubMedCrossRefGoogle Scholar
  113. 113.
    Flaherty JT, Magee PA, Gardner TL, et al. Comparison of intravenous nitroglycerine and sodium nitroprusside for treatment of acute hypertension developing after coronary bypass surgery. Circulation. 1982;65:1072.PubMedCrossRefGoogle Scholar
  114. 114.
    Bertolissi M, De Monte A, Giodano F. Comparison of intravenous nifedipine with sodium nitroprusside for treatment of acute hypertension after cardiac surgery. Minerva Anestesiol. 1998;64:321.PubMedGoogle Scholar
  115. 115.
    Chanda J, Canver CC. Reversal of preexisting vasospasm in coronary artery conduits. Ann Thorac Surg. 2001;72:476.PubMedCrossRefGoogle Scholar
  116. 116.
    Sladen RN, Klamerus KJ, Swafford MWG, et al. Labetalol for the control of elevated blood pressure following coronary artery bypass grafting. J Cardiothorac Anesth. 1990;4:210–221.PubMedCrossRefGoogle Scholar
  117. 117.
    Boldt J, Schindler E, Wollbruck M, et al. Cardiorespiratory response to intravenous angiotensin-converting enzyme inhibitor enalaprilat in hypertensive cardiac patients. J Cardiothorac Vasc Anesth. 1995;9:44.PubMedCrossRefGoogle Scholar
  118. 118.
    Gombotz H, Plaza J, Mahla E, et al. DA1 receptor stimulation by fenoldopam in the treatment of postcardiac surgical hypertension. Acta Anaesthesiol Scand. 1998;42(7):834.PubMedCrossRefGoogle Scholar
  119. 119.
    Davila-Roman VG, Waggoner AD, Hopkins WE, et al. Right ventricular dysfunction in low output syndrome after cardiac operations: assessment by transesophageal echocardiography. Ann Thorac Surg. 1995;60:1081.PubMedCrossRefGoogle Scholar
  120. 120.
    Gordon G, Rastegar H, Khabbaz K, et al. Perioperative use of nesiritide in adult cardiac surgery. Anesth Analg. 2004;98:SCA1.Google Scholar
  121. 121.
    Moazami N, Damiano RJ, Bailey MS, et al. Nesiritide (BNP) in the management of postoperative cardiac patients. Ann Thorac Surg. 2003;75:1974.PubMedCrossRefGoogle Scholar
  122. 122.
    Ichinose F, Robert JD Jr, Zapol WM. Inhaled nitric oxide. A selective pulmonary vasodilator. Current uses and therapeutic potential. Circulation. 2004;109:3106.PubMedCrossRefGoogle Scholar
  123. 123.
    Hache M, Denault A, Belisle S, et al. Inhaled epoprostenol (prostacyclin) and pulmonary hypertension before surgery. J Thorac Cardiovasc Surg. 2003;125:642.PubMedCrossRefGoogle Scholar
  124. 124.
    Sablotzki A, Czeslick E, Schubert S, et al. Iloprost improves hemodynamics in patients with severe chronic cardiac failure and secondary pulmonary hypertension. Can J Anaesth. 2002;49:1076.PubMedCrossRefGoogle Scholar
  125. 125.
    Brutsaert DL, Sys SU, Gillebert TC. Diastolic dysfunction in post-cardiac surgical management. J Cardiothorac Vasc Anesth. 1993;7(suppl 1):18.PubMedCrossRefGoogle Scholar
  126. 126.
    Waldo AL, Ross SM, Kaiser GA. The epicardial electrogram in the diagnosis of cardiac arrhythmias following cardiac surgery. Geriatrics. 1971;26:108.PubMedGoogle Scholar
  127. 127.
    Kirklin JK, Daggett WM, Lappas DG. Postoperative care following cardiac surgery. In: Johnson RA, Haber E, Austen WG, editors. The practice of cardiology. Boston: Little Brown; 1980. p. 1110.Google Scholar
  128. 128.
    Topol EJ, Lerman BB, Baughman KL, et al. De novo refractory ventricular tachyarrhythmias after coronary artery bypass revascularization. Am J Cardiol. 1986;57:57.PubMedCrossRefGoogle Scholar
  129. 129.
    Steinberg JS, Gaur A, Sciacca R, et al. New-onset sustained ventricular tachycardia after cardiac surgery. Circulation. 1999;99:903.PubMedCrossRefGoogle Scholar
  130. 130.
    Gollob MH, Seger JJ. Current status of the implantable cardioverter-defibrillator. Chest. 2001;119:1210.PubMedCrossRefGoogle Scholar
  131. 131.
    Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2000;102:I1.Google Scholar
  132. 132.
    Roden DM. A practical approach to torsades de pointes. Clin Cardiol. 1997;20:285.PubMedCrossRefGoogle Scholar
  133. 133.
    Laub GW, Muralidharan S, Janeira L, et al. Refractory postoperative torsades de pointes syndrome successfully treated with isoproterenol. J Cardiothorac Vasc Anest. 1993;7:210.CrossRefGoogle Scholar
  134. 134.
    Lauer MS, Eagle KA, Buckley MJ, et al. Atrial fibrillation following coronary artery bypass surgery. Prog Cardiovasc Dis. 1989;16:367–378.CrossRefGoogle Scholar
  135. 135.
    Aranki SF, Shaw DP, Adams DH, et al. Predictors of atrial fibrillation after coronary artery surgery: current trends and impact on hospital resources. Circulation. 1996;94:390.PubMedCrossRefGoogle Scholar
  136. 136.
    Maisel WH, Rawn JD, Stevenson WG. Atrial fibrillation after cardiac surgery. Ann Intern Med. 2001;135:1061.PubMedCrossRefGoogle Scholar
  137. 137.
    Asher CR, Chung MK, Grimm RA, et al. Is the incidence of postoperative atrial fibrillation following cardiac valve surgery reduced by minimally invasive surgery (abstract)? Circulation. 1996;94:651.CrossRefGoogle Scholar
  138. 138.
    Matthew JP, Parks R, Savino JS, et al. Atrial fibrillation after coronary artery bypass graft surgery: predictors, outcomes, and resource utilization. JAMA. 1996;276:300.CrossRefGoogle Scholar
  139. 139.
    Athanasiou T, Aziz O, Mangoush O, et al. Do off-pump techniques reduce the incidence of post-operatic atrial fibrillation in elderly patients undergoing coronary artery bypass grafting? Ann Thorac Surg. 2004;77:1567.PubMedCrossRefGoogle Scholar
  140. 140.
    Ellenbogen KA, Chung MK, et al. Postoperative atrial ­fibrillation. In: Karp RB, Laks H, Wechsler A, editors. Advances in cardiac surgery. 1997. vol. 9, p. 109.Google Scholar
  141. 141.
    Creswell LL, Schuessler RB, Rosenbloom M, et al. Hazards of postoperative atrial arrhythmias. Ann Thorac Surg. 1993;56:539.PubMedCrossRefGoogle Scholar
  142. 142.
    Frost L, Molgaard H, Christiansen EH, et al. Atrial fibrillation and flutter after coronary artery bypass grafting: epidemiology, risk factors and preventive trials. Int J Cardiol. 1992;36:253.PubMedCrossRefGoogle Scholar
  143. 143.
    Crosby LH, Pifalo WB, Woll KR, et al. Risk factors for atrial fibrillation after coronary artery bypass grafting. Am J Cardiol. 1990;66:1520.PubMedCrossRefGoogle Scholar
  144. 144.
    Leith JW, Thomson D, Baird DK, Harris PJ. The importance of age as a predictor of atrial fibrillation and flutter after coronary artery bypass grafting. J Thorac Cardiovasc Surg. 1990;10:338.Google Scholar
  145. 145.
    Hashimoto K, Illstrup DM, Schaff HV. Influence of clinical and hemodynamic variables on risk of supraventricular tachycardia after coronary artery bypass. J Thorac Cardiovasc Surg. 1991;101:55.Google Scholar
  146. 146.
    Andrews TC, Reimond SC, Berlin JA, Antman EM. Prevention of supraventricular arrhythmias after coronary artery bypass surgery: a meta-analysis of randomized controlled trials. Circulation. 1991;84(Suppl III):III236.PubMedGoogle Scholar
  147. 147.
    Ellenbogen KA, Dias VC, Plumb VJ, et al. A placebo-controlled trial of continuous intravenous diltiazem infusion for 24 hour heart rate control during atrial fibrillation and atrial flutter: a multicenter study. J Am Coll Cardiol. 1991;18:891.PubMedCrossRefGoogle Scholar
  148. 148.
    Moos AN, Wurdeman RL, Mahiuddin SM, et al. Esmolol versus diltiazem in the treatment of postoperative atrial fibrillation/flutter after open heart surgery. Am Heart J. 2000;140:176.CrossRefGoogle Scholar
  149. 149.
    Hilleman DE, Reyes AP, Moos AN, et al. Esmolol versus diltiazem in atrial fibrillation following coronary artery bypass graft surgery. Curr Med Res Opin. 2003;19:376.PubMedCrossRefGoogle Scholar
  150. 150.
    Ellenbogen KA, Dias VC, Cardello FP. Safety and efficacy of intravenous diltiazem in atrial fibrillation or atrial flutter. Am J Cardiol. 1995;75:45.PubMedCrossRefGoogle Scholar
  151. 151.
    Karth GD, Geppert A, Neunteufl T, et al. Amiodarone versus diltiazem for rate control in critically ill patients with atrial tachyarrhythmias. Crit Care Med. 2001;29:1149.CrossRefGoogle Scholar
  152. 152.
    Cheung AT, Weiss SJ, Savino JS. Acute circulatory actions of intravenous amiodarone loading in cardiac surgical patients. Ann Thorac Surg. 2003;76:535.PubMedCrossRefGoogle Scholar
  153. 153.
    Friedman PI, Hoffajie CD, Reiffel JA, et al. Practical approaches to treating atrial fibrillation. Cardiol Rev 1998;(Suppl 5):3.Google Scholar
  154. 154.
    Hjelms E. Proacainamide conversion of acute atrial fibrillation after open-heart surgery compared with digoxin treatment. Scand J Thorac Cardiovasc Surg. 1992;26:193.PubMedCrossRefGoogle Scholar
  155. 155.
    Dresing T. Tachyarrhythmias. In: Marso AP, Griffin BP, Topol EJ, editors. Manual of cardiovascular medicine. Philadelphia: Lippincott Williams and Wilkins; 2000.Google Scholar
  156. 156.
    Kay GN. Invited letter to the editor: amiodarone and quinidine for postoperative atrial arrhythmias. J Thorac Cardiovasc Surg. 1990;99:952.Google Scholar
  157. 157.
    McAlister HF, Luke RA, Whitlock RM, et al. Intravenous amiodarone bolus versus oral quinidine for atrial flutter and fibrillation after cardiac surgery. J Thorac Cardiovasc Surg. 1990;99:911.PubMedGoogle Scholar
  158. 158.
    Ellanbogan KA, Clemo HF, Stambler BS, et al. Efficacy of ibutilide for termination of atrial fibrillation and flutter. Am J Cardiol. 1996;78(Suppl 8A):42.CrossRefGoogle Scholar
  159. 159.
    Chung MK. Cardiac surgery: postoperative arrhythmias. Crit Care Med 2008;(suppl):N136.Google Scholar
  160. 160.
    Hill LL, De Wet C, Hogue CW Jr. Management of atrial fibrillation after cardiac surgery, Part II: prevention and treatment. J Cardiothorac Vasc Anesth. 2002;16:626.PubMedCrossRefGoogle Scholar
  161. 161.
    Solomon AJ. Pharmacological approach for the prevention of atrial fibrillation after cardiovascular surgery. Card Electrophysiol Rev. 2003;7:172.PubMedCrossRefGoogle Scholar
  162. 162.
    Kowey PR, Taylor JE, Rials SJ, Marinchak RA. Meta-analysis of the effectiveness of prophylactic drug therapy in preventing supraventricular arrhythmia early after coronary artery bypass grafting. Am J Cardiol. 1992;69:963.PubMedCrossRefGoogle Scholar
  163. 163.
    Fuller JA, Adams GG, Buxton B. Atrial fibrillation after coronary artery bypass grafting: is it a disorder of the elderly? J Thorac Cardiovasc Surg. 1989;98:821.Google Scholar
  164. 164.
    Matangi MF, Neutze JM, Grahm KJ, et al. Arrhythmia prophylaxis after aorto-coronary bypass: the effect of minidose propranolol. J Thorac Cardiovasc Surg. 1985;89:439.PubMedGoogle Scholar
  165. 165.
    Martinussen HJ, Lolk A, Szczepanski C, et al. Supraventricular tachyarrhythmias after coronary bypass surgery: a double blind randomized trial of prophylactic low dose propranolol. Thorac Cardiovasc Surg. 1988;36:206.PubMedCrossRefGoogle Scholar
  166. 166.
    Kaplan M, Kut MS, Icer UA, Dermirtas MM. Intravenous magnesium sulfate prophylaxis for atrial fibrillation after coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2003;125:344.PubMedCrossRefGoogle Scholar
  167. 167.
    Maslow AD, Regan MM, Heindle S, et al. Postoperative atrial tachyarrhythmias in patients undergoing coronary artery bypass graft surgery without cardiopulmonary bypass: a role for intraoperative magnesium supplementation. J Cardiothorac Vasc Anest. 2000;14:524.CrossRefGoogle Scholar
  168. 168.
    Kiziltepe U, Eyileten ZB, Sirlak M, et al. Antiarrhythmic effect of magnesium sulfate after open heart surgery: effect of blood levels. Int J Cardiol. 2003;89:153.PubMedCrossRefGoogle Scholar
  169. 169.
    Sanjuan R, Blasco M, Carbonell N, et al. Preoperative use of sotalol versus metoprolol in the prevention of atrial fibrillation after cardiac surgery. Ann Thorac Surg. 2004;77:838.PubMedCrossRefGoogle Scholar
  170. 170.
    Wurdeman RL, Mooss AN, Mohiuddin SM, Lenz TL. Amiodarone vs. sotalol as prophylaxis against atrial fibrillation/flutter after heart surgery. A meta-analysis. Chest. 2002;121:1203.PubMedCrossRefGoogle Scholar
  171. 171.
    Haan CK, Geraci SA. Role of amiodarone in reducing atrial fibrillation after cardiac surgery in adults. Ann Thorac Surg. 2002;73:1665.PubMedCrossRefGoogle Scholar
  172. 172.
    Yazigi A, Rahbani P, Zeid HA, et al. Postoperative oral amiodarone as prophylaxis against atrial fibrillation after coronary artery surgery. J Cardiothorac Vasc Anesth. 2002;16:603.PubMedCrossRefGoogle Scholar
  173. 173.
    Yagdi T, Nalbantgil S, Ayik F, et al. Amiodarone reduces the incidence of atrial fibrillation after coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2003;125:1420.PubMedCrossRefGoogle Scholar
  174. 174.
    Kaushik S, Hussain A, Clarke P, Lazar HL. Acute pulmonary toxicity after low-dose amiodarone therapy. Ann Thorac Surg. 2001;72:1760.PubMedCrossRefGoogle Scholar
  175. 175.
    Reed GL, Singer DE, Picard EH, et al. Stroke following coronary artery bypass surgery. N Eng J Med. 1988;319:1246.CrossRefGoogle Scholar
  176. 176.
    Arnold AZ, Mick MJ, Mazurek RP, et al. Role of prophylactic anticoagulation for direct current cardioversion in patients with atrial fibrillation and atrial flutter. J Am Coll Cardiol. 1989;13:617.CrossRefGoogle Scholar
  177. 177.
    Landolfo K, Smith P. Postoperative care in cardiac surgery. In: Sabiston DC, Spencer FC, editors. Surgery of the chest. 6th ed. Philadelphia: W.B. Saunders; 1995. p. 230–286.Google Scholar
  178. 178.
    Alajmo F, Calamai G. High-dose aprotinin in emergency coronary artery bypass after thrombolysis. Ann Thorac Surg. 1992;54:1022.PubMedCrossRefGoogle Scholar
  179. 179.
    Skinner JR, Phillips SJ, Zeff RH, Kongtahworn C. Immediate coronary bypass following failed streptokinase infusion in evolving myocardial infarction. J Thorac Cardiovasc Surg. 1984;87:567.PubMedGoogle Scholar
  180. 180.
    Stibbe J, Kluft C, Bommer EJ, et al. Enhanced fibrinolytic activity during cardiopulmonary bypass in open-heart surgery in man caused by extrinsic (tissue-type) plasminogen activator. Eur J Clin Invest. 1984;14:375.PubMedCrossRefGoogle Scholar
  181. 181.
    Esters JW. Kinetics of anticoagulation effect of heparin. JAMA. 1970;212:1492.CrossRefGoogle Scholar
  182. 182.
    Khuri SF, Wolfe JA, Josa M, et al. Hematologic changed during and after cardiopulmonary bypass and their relationship to the bleeding time and nonsurgical blood loss. J Thorac Cardiovasc Surg. 1992;104:94.PubMedGoogle Scholar
  183. 183.
    Boldt J, Knothe C, Zickmann B, et al. Platelet function in cardiac surgery: influence of temperature and aprotinin. Ann Thorac Surg. 1993;55:652.PubMedCrossRefGoogle Scholar
  184. 184.
    Harker LH. Bleeding after cardiopulmonary bypass. N Eng J Med. 1986;314:1446.CrossRefGoogle Scholar
  185. 185.
    Kestin AS, Valeri CR, Khuri SF, et al. The platelet function defect of cardiopulmonary bypass. Blood. 1993;82:107.PubMedGoogle Scholar
  186. 186.
    Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg. 2003;76:2121.PubMedCrossRefGoogle Scholar
  187. 187.
    Rawitscher RE, Jones JW, McCoy TA, Lindsley DA. A prospective study of aspirin’s effect on red cell losses in cardiac surgery. J Thorac Cardiovasc Surg (Torino). 1991;32:1.Google Scholar
  188. 188.
    John LC, Rees GM, Kovacs IB. Inhibition of platelet function by heparin: an etiologic factor in postbypass hemorrhage. J Thorac Cardiovasc Surg. 1993;105:816.PubMedGoogle Scholar
  189. 189.
    Gravlee GP, Rogers AT, Dudas LM, et al. Heparin management protocol for cardiopulmonary bypass influences heparin rebound but not bleeding. Anesthesiology. 1992;76:393.PubMedCrossRefGoogle Scholar
  190. 190.
    Teoh KH, Young E, Bradley CA, Hirsh J. Heparin binding proteins: contribution to heparin rebound after cardiopulmonary bypass. Circulation. 1993;88:II420.PubMedGoogle Scholar
  191. 191.
    Bick RL. Alterations in hemostasis associated with cardiopulmonary bypass; pathophysiology, prevention, diagnosis, and management. Semin Thromb Hemost. 1976;3:59.PubMedGoogle Scholar
  192. 192.
    Vertrees RA, Conti VR, Lick SD, et al. Adverse effects of postoperative infusion of shed mediastinal blood. Ann Thorac Surg. 1996;62:717.PubMedCrossRefGoogle Scholar
  193. 193.
    Schmaier AH. Diagnosis and therapy of disseminated intravascular coagulation and activated coagulation. In: Koepke JA, editor. Laboratory hematology Vol 2, Ch 25. New York:Churchill Livingstone; 1984.Google Scholar
  194. 194.
    Goodnough LT, Johnston MF, Ramsey G, et al. Guidelines for transfusion support in patients undergoing coronary artery bypass grafting. Transfusion Practices Committee of the American Association of Blood Banks. Ann Thorac Surg. 1990;50:675.PubMedCrossRefGoogle Scholar
  195. 195.
    Kirsh MM. Personal communication. 1978.Google Scholar
  196. 196.
    Ozkisacik E, Islamoglu F, Posacioglu H, et al. Desmopressin usage in elective cardiac surgery. J Cardiovasc Surg (Torino). 2001;42:741.Google Scholar
  197. 197.
    Gratz I, Koehler J, Olsen D, et al. The effect of desmopressin acetate on postoperative hemorrhage in patients receiving aspirin therapy before coronary artery bypass operations. J Thorac Cardiovasc Surg. 1992;104:1417.PubMedGoogle Scholar
  198. 198.
    Czer LSC, Bateman TM, Gray RJ, et al. Treatment of severe platelet dysfunction and hemorrhage after cardiopulmonary bypass: reduction in blood product usage with desmopressin. J Am Coll Cardiol. 1987;9:1139.PubMedCrossRefGoogle Scholar
  199. 199.
    Vander Salm TJ, Kaur S, Lancey RA, et al. Reduction of bleeding after heart operations through the prophylactic use of epsilon-aminocaproic acid. J Cardiovasc Surg. 1996;112:1098–1107.CrossRefGoogle Scholar
  200. 200.
    Lemmer JH, Stanford W, Bonney SL, et al. Aprotinin for primary coronary artery bypass grafting: a multicenter trial of three dose regimens. Ann Thorac Surg. 1996;62:1659–1668.PubMedCrossRefGoogle Scholar
  201. 201.
    Cicek S, Demirkilic U, Kuralay E, et al. Postoperative aprotinin: effect of blood loss and transfusion requirements in cardiac operations. Ann Thorac Surg. 1996;61:1372.PubMedCrossRefGoogle Scholar
  202. 202.
    Johnson RG, Thurer RL, Kruskal MS, et al. Comparison of two transfusion strategies after elective operations for myocardial revascularization. J Thorac Cardiovasc Surg. 1992;104:307.PubMedGoogle Scholar
  203. 203.
    Konishi T, Ohbayashi T, Kaneko T, et al. Preoperative use of erythropoietin for cardiovascular operations in anemia. Ann Thorac Surg. 1993;56:101.PubMedCrossRefGoogle Scholar
  204. 204.
    Griffth LD, Billman GF, Daily PO, Lane TA. Apparent coagulopathy caused by infusion of shed mediastinal blood and its prevention by washing of the infusate. Ann Thorac Surg. 1989;47:400.CrossRefGoogle Scholar
  205. 205.
    Axford TC, Dearani JA, Rango G, et al. Safety and therapeutic effectiveness of reinfused shed blood after open-heart surgery. Ann Thorac Surg. 1994;57:615.PubMedCrossRefGoogle Scholar
  206. 206.
    Vertrees RA, Conti VR, Lick SD, et al. Adverse effects of postoperative infusion of shed mediastinal blood. Ann Thorac Surg. 1996;662:717.CrossRefGoogle Scholar
  207. 207.
    Czer LCS. Mediastinal bleeding after cardiac surgery: etiologies, diagnostic consideration, and blood conservation methods. J Cardiothorac Anesth. 1989;3:760.PubMedCrossRefGoogle Scholar
  208. 208.
    Woodman RC, Harker LA. Bleeding complications associated with cardiopulmonary bypass. Blood. 1990;76:1680.PubMedGoogle Scholar
  209. 209.
    Moulton MJ, Creswell LL, Mackey ME, et al. Re-exploration for bleeding is a risk factor for increased morbidity and mortality. J Thorac Cardiovasc Surg. 1996;111:1037.PubMedCrossRefGoogle Scholar
  210. 210.
    Karthik S, Grayson AD, McCarron EE, et al. Re-exploration after coronary bypass surgery: risk factors, outcomes, and the effect of time delay. Ann Thorac Surg. 2004;78:1888.Google Scholar
  211. 211.
    Chenoweth DE, Cooper SW, Hugli TE, et al. Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins. N Engl J Med. 1981;304:497.PubMedCrossRefGoogle Scholar
  212. 212.
    Butler J, Chong GL, Baigrie RJ, et al. Cytokine responses to cardiopulmonary bypass with merman and bubble oxygenation. Ann Thorac Surg. 1992;53:833.PubMedCrossRefGoogle Scholar
  213. 213.
    Barrowcliffe MP, Jones GJ. Solute permeability of the alveolar capillary barrier. Thorax. 1987;42:1.PubMedCrossRefGoogle Scholar
  214. 214.
    McGowan F, Ikegonui N, Del Nido P, et al. Cardiopulmonary bypass significantly reduces surfactant activity in children. J Thorac Cardiovasc Surg. 1993;106:968.PubMedGoogle Scholar
  215. 215.
    Higgins TL, Barret C, Riden DJ, et al. The influence of pleural and mediastinal chest tubes on respiration following coronary artery bypass grafting (CABG). Chest. 1989;96(suppl):237S.Google Scholar
  216. 216.
    Sladden RN, Berkowitz DE. Cardiopulmonary bypass and the lung. In: Gravlee GP, Davis RF, Utley IR, editors. Cardiopulmonary bypass. Philadelphia: Williams & Wilkins; 1993. p. 468.Google Scholar
  217. 217.
    Markland ON, Moorthy SS, Mahomed Y, et al. Postoperative phrenic nerve palsy in patients with open-heart surgery. Ann Thorac Surg. 1985;39:68.CrossRefGoogle Scholar
  218. 218.
    Kollef MH, Schuster DP. The acute respiratory distress syndrome. N Eng J Med. 1995;332:27.CrossRefGoogle Scholar
  219. 219.
    Peruzzi WT, Franklin ML, Shapiro BA. New concepts and therapies of adult respiratory distress syndrome. J Cardiothorac Vasc Anesthesia. 1997;11:771.CrossRefGoogle Scholar
  220. 220.
    Porter GA, Kloster FE, Herr RJ, et al. Relationship between alteration in renal hemodynamics during cardiopulmonary bypass and postoperative renal function. Circulation. 1966;34:1005.PubMedCrossRefGoogle Scholar
  221. 221.
    Finterbusch W, Long DM, Sellers RD, et al. Renal arteriography during extracorporeal circulation in dogs with a preliminary report upon the effects of low molecular weight dextran. J Thorac Cardiovasc Surg. 1961;41:252.Google Scholar
  222. 222.
    Moghissi K, Mac Lell ES, Munday KA. Changes in renal blood flow and PAH extraction during extracorporeal circulation of short and long duration. Cardiovasc Res. 1969;3:37.PubMedCrossRefGoogle Scholar
  223. 223.
    Andrews TC, Reimond SC, Berlin JA, Antman EM. Prevention of supraventricular arrhythmias after coronary artery bypass surgery: a meta-analysis of randomized control trials. Circulation. 1991;84:III241.Google Scholar
  224. 224.
    Hickey PR, Buckley MJ, Philbin DM. Pulsatile and nonpulsatile cardiopulmonary bypass: review of a counterproductive controversy. Ann Thorac Surg. 1983;36:720–737.PubMedCrossRefGoogle Scholar
  225. 225.
    Boldt J, Brenner T, Lehman A, et al. Is kidney function altered by the duration of cardiopulmonary bypass? Ann Thorac Surg. 2003;75:906.PubMedCrossRefGoogle Scholar
  226. 226.
    Antunes PE, Prieto D, de Oliveira JF, et al. Renal dysfunction after myocardial revascularization. Eur J Cardiothorac Surg. 2004;25:597.PubMedCrossRefGoogle Scholar
  227. 227.
    Young EW, Diab A, Kirsh MM. Intravenous diltiazem and acute renal failure after cardiac operations. Ann Thorac Surg. 1998;65:1316.PubMedCrossRefGoogle Scholar
  228. 228.
    Swaminathan M, East C, Phillips-Bute B, et al. Report of a substudy of warm versus cold cardiopulmonary bypass: changes in creatinine clearance. Ann Thorac Surg. 2001;72:1603.PubMedCrossRefGoogle Scholar
  229. 229.
    Grayson AD, Khater M, Jackson M, Fox MA. Valvular heart surgery is an independent risk for acute renal failure. Ann Thorac Surg. 2003;75:1829.PubMedCrossRefGoogle Scholar
  230. 230.
    Zanardo G, Michielon P, Paccagnella A, et al. Acute renal failure in the patient undergoing cardiac operation. Prevalence, mortality rate, and main risk factors. J Thorac Cardiovasc. 1994;107:1489.Google Scholar
  231. 231.
    Corwin HL, Sprague SM, DeLaria GA, Norusis MJ. Acute renal failure associated with cardiac operations. A case study. J Thorac Cardiovasc Surg. 1989;98:1107.PubMedGoogle Scholar
  232. 232.
    Lange HW, Aepple DM, Brown DC. Survival of patients with acute renal failure requiring dialysis after open-heart surgery: early prognostic indicators. Am Heart J. 1987;113:1138.PubMedCrossRefGoogle Scholar
  233. 233.
    Alfieri A, Kolter MN. Noncardiac complications of open-heart surgery. Am Heart J. 1990;119:149.PubMedCrossRefGoogle Scholar
  234. 234.
    Bhat JG, Gluck ML, Lowenstein J, Baldwin DS. Acute renal failure after open-heart surgery. Ann Intern Med. 1976;84:677.PubMedCrossRefGoogle Scholar
  235. 235.
    Tang AT, et-Gamel A, Keevil B, et al. The effect of “renal dose” dopamine on renal tubular function following cardiac surgery; assessed by measuring retinol binding protein (RBP). Eur J Cardiothorac Surg. 1999;15:717.PubMedCrossRefGoogle Scholar
  236. 236.
    Cammi PP, Pagani L, Micalizzi E, et al. Fenoldopam for renal protection in patients undergoing cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2003;17:491.CrossRefGoogle Scholar
  237. 237.
    Anderson LW, Landow L, Baek L, et al. Association between gastric intramucosal pH and splanchnic endotoxins, antibody to endotoxin, and tumor necrosis factor concentrations in patients undergoing cardiopulmonary bypass. Crit Care Med. 1993;21:210.CrossRefGoogle Scholar
  238. 238.
    Aranha G, Picklenan J, Pifarre R, et al. The reasons for ­gastrointestinal consultation after cardiac surgery. Am Surg. 1984;50:301.PubMedGoogle Scholar
  239. 239.
    Tsiotos GG, Mullany CJ, Zietlow S, van Heerden JA. Abdominal complications following cardiac surgery. Am J Surg. 1994;167:553.PubMedCrossRefGoogle Scholar
  240. 240.
    Krasna MJ, Flancbaum L, Trooskin SZ, et al. Gastrointestinal complications after cardiac surgery. Surgery. 1988;104:773.PubMedGoogle Scholar
  241. 241.
    Rosemurgy AS, McAllister E, Karl RC. The acute surgical abdomen after cardiac surgery involving extracorporeal circulation. Ann Surg. 1988;207:323.PubMedCrossRefGoogle Scholar
  242. 242.
    Welling RE, Rath R, Albers JE, Glaser RS. Gastrointestinal complications after cardiac surgery. Arch Surg. 1986;121:1178.PubMedCrossRefGoogle Scholar
  243. 243.
    Christenson JT, Schmuziger M, Maurice J, et al. Gastrointestinal complications after coronary artery bypass grafting. J Thorac Cardiovasc Surg. 1994;108:899.PubMedGoogle Scholar
  244. 244.
    Cook D, Guyatt G, Marshall J, et al. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. N Eng J Med. 1998;338:791.CrossRefGoogle Scholar
  245. 245.
    Wang MJ, Chao A, Huang CH, et al. Hyperbilirubinemia after cardiac operation. Incidence, risk factors and clinical significance. J Thorac Cardiovasc Surg. 1994;108:429.PubMedGoogle Scholar
  246. 246.
    Raman JS, Kichi K, Morimatsu H, et al. Severe ischemic early liver injury after cardiac surgery. Ann Thorac Surg. 2002;74:1601.PubMedCrossRefGoogle Scholar
  247. 247.
    Tremolada F, Lorregian M, Antona C, et al. Blood transmitted and clotting factor transmitted Non-A, Non-B hepatitis. J Clin Gastroenterol. 1998;10:413.CrossRefGoogle Scholar
  248. 248.
    Rattner DW, Gu ZY, Vlahakes GJ, et al. Hyperamylasemia after cardiac surgery. Incidence, significance, and management. Ann Thorac Surg. 1989;209:279.CrossRefGoogle Scholar
  249. 249.
    Haas GS, Warshaw AL, Daggett WM, Aretz HT. Acute pancreatitis after cardiopulmonary bypass. Am J Surg. 1985;149:508.PubMedCrossRefGoogle Scholar
  250. 250.
    Aglio LS, Stanford GG, Maddi R, et al. Hypomagnesemia is common following cardiac surgery. J Cardiothorac Anesthesia. 1991;5:201.CrossRefGoogle Scholar
  251. 251.
    Prielipp RC, Zaloga GP, Butterworth JF. Magnesium inhibits the hypertensive but not the cardiotonic actions of low-dose epinephrine. Anesthesiology. 1991;74:973.PubMedCrossRefGoogle Scholar
  252. 252.
    Frater RW, Oka Y, Kadish A, et al. Diabetes and coronary artery surgery. Mt Sinai J Med. 1982;49:237.PubMedGoogle Scholar
  253. 253.
    Seki S. Clinical features of hyperosmolar nonketotic diabetic coma associated with cardiac operations. J Thorac Cardiovasc Surg. 1986;91:867.PubMedGoogle Scholar
  254. 254.
    Crittenden MD, Khuri SF. The effect of cardiopulmonary bypass on platelet function and platelet kinetics. In: Attar S, editor. Hemostasis in cardiac surgery. Armonk: Futura Publishing; 1999. p. 3.Google Scholar
  255. 255.
    George JN, Pickett EB, Saucerman S, et al. Platelet surface glycoproteins: studies on resting and activated platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery. J Clin Invest. 1986;78:340.PubMedCrossRefGoogle Scholar
  256. 256.
    Harker L, Malpass TW, Branson HE, et al. Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective a-granule release. Blood. 1980;56:824.PubMedGoogle Scholar
  257. 257.
    Valeri CR, Cassidy G, Khuri S, et al. Hypothermia-induced reversible platelet dysfunction. Ann Thorac Surg. 1987;205:175.CrossRefGoogle Scholar
  258. 258.
    Brieger DB, Mak KH, Kottke-Marchant K, Topol EJ. Heparin-induced thrombocytopenia. J Am Coll Cardiol. 1998;31:1449.PubMedCrossRefGoogle Scholar
  259. 259.
    Shorten GD, Comunale ME. Heparin-induced ­thrombocytopenia. J Cardiothorac Vasc Anesth. 1996;10:521.PubMedCrossRefGoogle Scholar
  260. 260.
    Kollef MH, Sharpless L, Vlasnik J, et al. The impact of ­nosocomial infections on patient outcome following cardiac surgery. Chest. 1997;112:666.PubMedCrossRefGoogle Scholar
  261. 261.
    Breyer RH, Mills SA, Hudspeth AS, et al. A prospective study of sternal wound complications. Ann Thorac Surg. 1984;37:412.PubMedCrossRefGoogle Scholar
  262. 262.
    Culliford AT, Cunningham JN Jr, Zeff RH, et al. Sternal and costochondral infections following open-heart surgery. A review of 2,594 cases. J Thorac Cardiovasc Surg. 1976;72:714.PubMedGoogle Scholar
  263. 263.
    Cheung EH, Craver JM, Jones EL, et al. Mediastinitis after cardiac valve operations: impact upon survival. J Thorac Cardiovasc Surg. 1985;90:517.PubMedGoogle Scholar
  264. 264.
    Demmy TL, Park SB, Liebler GA, et al. Recent experience with major sternal wound complications. Ann Thorac Surg. 1990;49:458.PubMedCrossRefGoogle Scholar
  265. 265.
    Ottino G, DePaulis R, Pansini G, et al. Major sternal wound infections after open-heart surgery: a multivariate analysis of risk factors in 2,579 consecutive operative procedures. Ann Thorac Surg. 1987;44:173.PubMedCrossRefGoogle Scholar
  266. 266.
    Gottleib LJ, Pielet RW, Karp RP, et al. Rigid internal fixation of the sternum in postoperative mediastinitis. Arch Surg. 1994;129:489.CrossRefGoogle Scholar
  267. 267.
    Cosgrove DM, Lytle BW, Loop FD, et al. Does bilateral internal mammary artery grafting increase surgical risk? J Thorac Cardiovasc Surg. 1988;95:850.PubMedGoogle Scholar
  268. 268.
    Gottlieb LJ, Beahm EK, Krizek TJ, Karp RB. Approaches to sternal wound infections. In: Karp RB, Laks H, Wechsler AS, editors. Advance in cardiac surgery. 1996. vol. 7, p. 147.Google Scholar
  269. 269.
    Verkkala K. Occurrence of and microbiological findings in postoperative infections following open-heart surgery. Effect on mortality and hospital stay. Ann Clin Res. 1987;19:170.PubMedGoogle Scholar
  270. 270.
    Kay HR, Goodman LR, Teplick SK, Mundth ED. Use of computed tomography to assess mediastinal complications after median sternotomy. Ann Thorac Surg. 1983;36:705.CrossRefGoogle Scholar
  271. 271.
    Gur E, Stern D, Weiss J, et al. Clinical-radiological evaluation of poststernotomy wound infections. Plast Reconstr Surg. 1998;101:348.PubMedCrossRefGoogle Scholar
  272. 272.
    Misawa Y, Fuse K, Hasegawa T. Infectious mediastinitis after cardiac operations: computed tomographic findings. Ann Thorac Surg. 1998;65:622.PubMedCrossRefGoogle Scholar
  273. 273.
    DeLaria GA, Hunter JA, Goldin MD, et al. Leg wound complications associated with coronary revascularization. J Thorac Cardiovasc Surg. 1981;81:403.PubMedGoogle Scholar
  274. 274.
    Loop FD, Cosgrove DM, Lytle BW, et al. An 11 year evolution of coronary arterial bypass grafting (1968–1978). Ann Surg. 1979;190:444.PubMedCrossRefGoogle Scholar
  275. 275.
    Gardner TJ, Hoeneffer PJ, Manolio TA, et al. Stroke following coronary artery bypass grafting: a ten year study. Ann Thorac Surg. 1985;40:574.PubMedCrossRefGoogle Scholar
  276. 276.
    Taylor GJ, Malik SA, Colliver JA, et al. Usefulness of atrial fibrillation as a predictor of stroke after isolated coronary artery bypass grafting. Am J Cardiol. 1987;60:905.PubMedCrossRefGoogle Scholar
  277. 277.
    Tuman KJ, McCarthy RJ, Najafi H, Ivankovich AD. Differential effects of advanced age on neurologic and cardiac risks of coronary artery operations. J Thorac Cardiovasc Surg. 1992;104:1510.PubMedGoogle Scholar
  278. 278.
    Lynn GM, Stefanko K, Reed JF III, et al. Risk factors for stoke after coronary artery bypass. J Thorac Cardiovasc Surg. 1992;104:1518.PubMedGoogle Scholar
  279. 279.
    Furlan AJ, Breuer AC. Central nervous system complications of open-heart surgery. Stoke. 1984;15:912.Google Scholar
  280. 280.
    Smith LW, Dimsdale JE. Postcardiotomy delirium: conclusions after 25 years? Am J Psychiatry. 1989;146:452.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ross F. DiMarcoJr.
    • 1
  1. 1.Cardiovascular Thoracic Surgery, Department of SurgeryUPMC Mercy Hospital of PittsburghPittsburghUSA

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