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Sepsis

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Surgical Intensive Care Medicine

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Abstract

Sepsis represents the body’s response to an infectious insult. It is characterized by the dysregulation of the inflammatory response and of the coagulation homeostasis leading to a pro-inflammatory, prothrombotic, and antifibrinolysis state. Depending on the host’s predisposition and comorbidities, as well as on the nature and intensity of the insult, sepsis may progress to severe sepsis, which may be associated with circulatory shock, cellular dysfunction, multiple organ failure, and death.

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Authors and Affiliations

  1. Department of Critical Care, Hospital de Terapia Intensiva, Universidade Estadual Do Piauí, Teresina, PI, Brazil

    Patricia Mello (Director, Intensive Care Unit)

  2. Division of Critical Care Medicine, Robert Wood Johnson Medical School, Cooper University Hospital, University of Medicine and Dentistry of New Jersey, Camden, NJ, USA

    R. Phillip Dellinger (Professor of Medicine, Head)

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  1. Patricia Mello
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Editors and Affiliations

  1. Department of Surgical Critical Care Division of Surgery, The Lahey Clinic Medical Center, Burlington, MA, USA

    John M. O’Donnell (Director, Surgical Intensive Care Unit Chairman) (Director, Surgical Intensive Care Unit Chairman)

  2. University Hospital Intensive Care Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

    Flávio E. Nácul

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Mello, P., Dellinger, R.P. (2010). Sepsis. In: O’Donnell, J.M., Nácul, F.E. (eds) Surgical Intensive Care Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77893-8_27

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