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Supplemental Oxygen Therapy

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Surgical Intensive Care Medicine
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Abstract

Intensivists caring for critically ill patients in a surgical intensive care unit continually face multiple diverse and challenging problems. While the specific disease processes in these patients are myriad, a fundamental goal is to provide adequate cellular respiration and thereby maintain sufficient tissue oxygenation and normal organ function. Successful cellular respiration depends on the maintenance of several factors, including adequate alveolar ventilation, a functioning gas-exchange surface, the capacity to transport oxygen to the tissue, and intact tissue respiration (the mitochondrial cytochrome oxidase system). Subsequent chapters in this textbook describe problems with each of these factors and how intensivists should approach and manage them. This chapter focuses on alveolar ventilation and how to use supplemental oxygen therapy to improve arterial oxygenation in patients who are hypoxemic but do not require mechanical ventilation.

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References

  1. Levitzky MG. Pulmonary Physiology, 7th ed. New York: McGraw-Hill, 2007.

    Google Scholar 

  2. Kennedy TC, Knudson RJ. Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis. Chest 1977;72:305–9.

    Article  PubMed  CAS  Google Scholar 

  3. West JB. Pulmonary Pathophysiology—The Essentials, 7th ed. Baltimore: Lippincott Williams & Wilkins, 2007.

    Google Scholar 

  4. West JB. Respiratory Physiology—The Essentials, 8th ed. Baltimore: Lippincott Williams & Wilkins, 2008.

    Google Scholar 

  5. AARC (American Association for Respiratory Care) clinical practice guideline. Oxygen therapy in the acute care hospital. Respir Care 1991;36:1410–13.

    Google Scholar 

  6. Scanlan CL, Heuer A. Medical gas therapy. In: Scanlan CL, Wilkins RL, Stoller JK, eds. Egan’s Fundamentals of Respiratory Care. 7th ed. St. Louis: Mosby, 1999:737–70.

    Google Scholar 

  7. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 1999;34:646–56.

    Article  PubMed  CAS  Google Scholar 

  8. Turnbull TL, Hart RG, Strange GR, et al. Emergency department screening for unsuspected carbon monoxide exposure. Ann Emerg Med 1988;17:478–83.

    Article  PubMed  CAS  Google Scholar 

  9. Barret L, Danel V, Faure J. Carbon monoxide poisoning, a diagnosis frequently overlooked. J Toxicol Clin Toxicol 1985;23:309–13.

    Article  PubMed  CAS  Google Scholar 

  10. Dekich SE, Olsen GN. Techniques for administering oxygen effectively in the ICU. J Crit Illn 1989; 4:95–103.

    Google Scholar 

  11. Goldstein RS, Young J, Rebuck AS. Effect of breathing pattern on oxygen concentration received from standard face masks. Lancet 1982;2:1188–90.

    Article  PubMed  CAS  Google Scholar 

  12. Peruzzi WT, Shapiro BA. Respiratory care. In: Murray MJ, Coursin DB, Pearl RG, Prough DS, eds. Critical Care Medicine: Periopera-tive Management. Philadelphia: Lippincott-Raven, 1997.

    Google Scholar 

  13. Scacci R. Air entrainment masks: jet mixing is how they work; the Bernoulli and Venturi principles are how they don’t. Respir Care 1979;24:928–31.

    Google Scholar 

  14. Irwin RS, French CL, Mike RW. Respiratory adjunct therapy. In: Rippe JM, Irwin RS, Alpert JS, Fink MP (eds). Intensive Care Medicine, 2nd ed.. Boston: Little, Brown, 1991.

    Google Scholar 

  15. Kass JE, Castriotta RJ. Heliox therapy in acute severe asthma. Chest 1995; 107:757–60.

    Article  PubMed  CAS  Google Scholar 

  16. Shiue ST, Gluck EH. The use of helium-oxygen mixtures in support of patients with status asthmaticus and respiratory acidosis. J Asthma 1989;26:177–80.

    Article  PubMed  CAS  Google Scholar 

  17. Christopherson SK, Hlastala MP. Pulmonary gas exchange during altered density gas breathing. J Appl Physiol 1982;52:221–5.

    PubMed  CAS  Google Scholar 

  18. Manthous CA, Hall JB, Caputo MA, et al. Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma. Am J Respir Crit Care Med. 1995;151:310–14.

    Article  PubMed  CAS  Google Scholar 

  19. Manthous CA, Morgan S, Pohlman A, Hall JB. Heliox in the treatment of airflow obstruction: A critical review of the literature. Respir Care 1997;42:1032–42.

    Google Scholar 

  20. Katz JA. PEEP and CPAP in perioperative respiratory care. Respir Care 1984;29:614–29.

    Google Scholar 

  21. Branson RD, Hurst JM, DeHaven CB Jr. Mask CPAP: state of the art. Respir Care 1985;30:846–57.

    PubMed  CAS  Google Scholar 

  22. Putensen C, Hormann C, Baum M, Lingnau W. Comparison of mask and nasal continuous positive airway pressure after extuba-tion and mechanical ventilation. Crit Care Med 1993;21:357–62.

    Article  PubMed  CAS  Google Scholar 

  23. Bersten AD, Holt AW, Vedig AE, Skowronski GA, Baggoley CJ. Treatment of severe cardiogenic pulmonary edema with continuous positive airway pressure delivered by face mask. N Engl J Med 1991;325:1825–30.

    Article  PubMed  CAS  Google Scholar 

  24. Lin M, Yang YF, Chiang HT, Chang MS, Chiang BN, Cheitlin MD. Reappraisal of continuous positive airway pressure therapy in acute cardiogenic pulmonary edema. Short-term results and long-term follow-up. Chest 1995;107:1379–86.

    Article  PubMed  CAS  Google Scholar 

  25. Kramer N, Meyer TJ, Meharg J, Cece RD, Hill NS. Randomized, prospective trial of noninvasive positive pressure ventilation in acute respiratory failure. Am J Respir Crit Care Med 1995;151: 1799–806.

    Article  PubMed  CAS  Google Scholar 

  26. Masip J, Roque M, Sanchez B, Fernandez R, Subirana M, Expos-ito JA. Noninvasive ventilation in acute cardiogenic pulmonary edema. JAMA 2005;294:3124–3130.

    Article  PubMed  CAS  Google Scholar 

  27. Mehta S, Jay GD, Woolard RH, Hipona RA, et al. Randomized prospective trial of bilevel versus continuous positive airway pressure in acute pulmonary edema. Crit Care Med 1997; 25:620–628.

    Article  PubMed  CAS  Google Scholar 

  28. Crane SD, Elliott MW, Gilligan P, Richards K, Gray AJ. Randomised controlled comparison of continuous positive airways pressure, bilevel non-invasive ventilation, and standard treatment in emergency department patients with acute cardiogenic pulmonary oedema. Emerg Med J 2004; 21:155–161.

    Article  PubMed  CAS  Google Scholar 

  29. Abou-Shala N, Meduri U. Noninvasive mechanical ventilation in patients with acute respiratory failure. Crit Care Med 1996;24: 705–15.

    Article  PubMed  CAS  Google Scholar 

  30. Bott J, Carroll MP, Conway JH, et al. Randomized controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease. Lancet 1993;341:1555–57.

    Article  PubMed  CAS  Google Scholar 

  31. Brochard L, Mancebo J, Wysocki M, et al. Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med 1995;333:817–22.

    Article  PubMed  CAS  Google Scholar 

  32. Wysocki M, Tric L, Wolff MA, Millet H, Herman B. Noninva-sive pressure support ventilation in patients with acute respiratory failure. A randomized comparison with conventional therapy. Chest 1995;107:761–68.

    Article  PubMed  CAS  Google Scholar 

  33. Mehta S, Jay GD, Woolard RH, et al. Randomized, prospective trial of bilevel versus continuous positive airway pressure in acute pulmonary edema. Crit Care Med 1997;25:620–28.

    Article  PubMed  CAS  Google Scholar 

  34. Antonelli M, Conti G, Rocco M, et al. A comparison of nonin-vasive positive-pressure ventilation and conventional mechanical ventilation in patients with acute respiratory failure. N Engl Med 1998;339:429–35.

    Article  CAS  Google Scholar 

  35. Nava S, Ambrosino N, Clini E, et al. Noninvasive mechanical ventilation in the weaning of patients with respiratory failure due to chronic obstructive pulmonary disease. A randomized, controlled trial. Ann Intern Med 1998;128:721–28.

    Article  PubMed  CAS  Google Scholar 

  36. Girault C, Daudenthun I, Chevron V, Tamion F, Leroy J, Bon-marchand G. Noninvasive ventilation as a systematic extubation and weaning technique in acute-on-chronic respiratory failure: a prospective, randomized controlled study. Am J Respir Crit Care Med 1999;160:86–92.

    Article  PubMed  CAS  Google Scholar 

  37. Lightowler J, Non-invasive positive pressure ventilation for the treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease (Cochrane Review). BMJ 2003:185–9.

    Google Scholar 

  38. Keenan SP, Sinuff T, Cook DJ, Hill N. Which patients with acute exacerbation of chronic obstructive pulmonary disease benefit from noninvasive positive pressure ventilation? A systematic review of the literature. Ann Intern Med 2003;138: 861–870.

    Article  PubMed  Google Scholar 

  39. Elliott MW. Non-invasive ventilation in acute exacerbations of chronic obstructive pulmonary disease: a new gold standard? Intensive Care Med 2002;28:1691–4.

    Article  PubMed  CAS  Google Scholar 

  40. Hill NS. Complications of noninvasive positive pressure ventilation. Respir Care 1997;42:432–42.

    Google Scholar 

  41. Mellemgaard K. The alveolar-arterial oxygen difference: its size and components in normal man. Acta Physiol Scand 1966;67: 10–20.

    Article  PubMed  CAS  Google Scholar 

  42. Kanber GJ, King FW, Eshchar YR, Sharp JT. The alveolar-arterial oxygen gradient in young and elderly men during air and oxygen breathing. Am Rev Respir Dis 1968;97:376–81.

    PubMed  CAS  Google Scholar 

  43. Gilbert R, Keighley JF. The arterial-alveolar oxygen tension ratio. An index of gas exchange applicable to varying inspired oxygen concentrations. Am Rev Respir Dis 1974;109:142–5.

    PubMed  CAS  Google Scholar 

  44. Peris LV, Boix JH, Salom JV, Valentin V, Garcia D, Amau A. Clinical use of the arterial/alveolar oxygen tension ratio. Crit Care Med 1983;11:888–91.

    Article  PubMed  CAS  Google Scholar 

  45. Severinghaus JW, Astrup PB. History of blood gas analysis. VI. Oximetry. J Clin Monit 1986;2:270–88.

    Article  PubMed  CAS  Google Scholar 

  46. Severinghaus JW, Kelleher JF. Recent developments in pulse oxim-etry. Anesthesiology 1992;76:1018–38.

    Article  PubMed  CAS  Google Scholar 

  47. Tremper KK, Barker SJ. Pulse oximetry. Anesthesiology 1989;70: 98–108.

    Article  PubMed  CAS  Google Scholar 

  48. Kelleher JF. Pulse oximetry. J Clin Monit 1989;5:37–62.

    Article  PubMed  CAS  Google Scholar 

  49. LeGrand TS, Peters JI. Pulse oximetry: advantages and pitfalls: the key is knowing what it can—and cannot—tell you. J Respir Dis 1999;20:195–200,206.

    Google Scholar 

  50. Ralston AC, Webb RK, Runciman WB. Potential errors in pulse oxi-metry. I. Pulse oximeter evaluation. Anaesthesia 1991;46:202–6.

    Article  PubMed  CAS  Google Scholar 

  51. Campbell EJ. The J. Burns Amberson Lecture. The management of acute respiratory failure in chronic bronchitis and emphysema. Am Rev Respir Dis 1967;96:626–39.

    PubMed  CAS  Google Scholar 

  52. Mithoefer JC, Karetzky MS, Mead GD. Oxygen therapy in respiratory failure. N Engl J Med 1967:277:947–9.

    Article  PubMed  CAS  Google Scholar 

  53. Bradley CA, Fleetham JA, Anthonisen NR. Ventilatory control in patients with hypoxemia due to obstructive lung disease. Am Rev Respir Dis 1979;120:21–30.

    PubMed  CAS  Google Scholar 

  54. Fleetham JA, Bradley CA, Kryger MH, Anthonisen NR. The effect of low flow oxygen therapy on the chemical control of ventilation in patients with hypoxemic COPD. Am Rev Respir Dis 1980;122:833–40.

    PubMed  CAS  Google Scholar 

  55. Campbell EJ. Respiratory failure. Definition, mechanisms and recent developments. Bull Eur Physiopathol Respir 1979;15(Suppl):1–13.

    PubMed  Google Scholar 

  56. Lenfant C. Arterial-alveolar difference in PCO2 during air and oxygen breathing. J Appl Physiol 1966;21:1356–62.

    PubMed  CAS  Google Scholar 

  57. West JB. Causes of carbon dioxide retention in lung disease. N Engl J Med 1971;284:1232–36.

    Article  PubMed  CAS  Google Scholar 

  58. Aubier M, Murciano D, Milic-Emili J, et al. Effects of the administration of O2 on ventilation and blood gases in patients with chronic obstructive pulmonary disease during acute respiratory failure. Am Rev Respir Dis 1980;122:747–54.

    PubMed  CAS  Google Scholar 

  59. Robinson TD, Freiberg DB, Regnis JA, Young IH. The role of hypoventilation and ventilation-perfusion redistribution in oxygen-induced hypercapnia during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000;161:1524–9.

    Article  PubMed  CAS  Google Scholar 

  60. Schwartzstein RM, Parker MJ. Respiratory Physiology: A Clinical Approach. Lippincott Williams & Wilkins. 2006.

    Google Scholar 

  61. Deneke SM, Fanburg BL. Normobaric oxygen toxicity of the lung. N Engl J Med 1980;303:76–86.

    Article  PubMed  CAS  Google Scholar 

  62. Klein J. Normobaric pulmonary oxygen toxicity. Anesth Analg 1990;70:195–207.

    Article  PubMed  CAS  Google Scholar 

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Villanueva, A.G. (2010). Supplemental Oxygen Therapy. In: O’Donnell, J.M., Nácul, F.E. (eds) Surgical Intensive Care Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77893-8_1

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  • DOI: https://doi.org/10.1007/978-0-387-77893-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-77892-1

  • Online ISBN: 978-0-387-77893-8

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