• Michael E. Starzak


A protein with two independent ligand binding sites resolves into two single site partition functions even if the two sites have different binding parameters. The distinct sites can even be on different proteins. Interaction between two sites with bound ions requires an additional interaction energy so that the total partition function cannot be factored. For example, charged ions on two neighboring sites repel each other and the repulsion energy Boltzmann factor is included in the Boltzmann factor for the state with ions at each site.


Partition Function Excess Charge Boltzmann Factor Total Interaction Energy Double Layer Potential 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of ChemistryState University of New York BinghamtonBinghamtonUSA

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