Abstract
Hydroxyapatite and related calcium phosphates (CaPs) are similar in composition to the mineral part of bones and teeth. Synthetic CaPs are successfully used for filling bone defects in various clinical indications as they are considered bioactive and osteoconductive, guiding the bone healing process. Nevertheless, most of the synthetic bone substitutes lack the osteoinductive property for regenerating bone tissue over large defects. This chapter reviews the biological properties of CaP materials in relation to their chemistry, crystallographic structure, and solubility. Recent studies have shown that some macro and micro porous CaP ceramics have led to ectopic bone formation when implanted in muscles of animals. Although the interactions of these CaP materials with body fluids, cells, and tissues have been investigated at both the microscopic and ultrastructural levels, there is still a lack of understanding of the possible mechanisms leading to osteoinduction. Both the study of cell–material interactions in vitro and immunochemistry techniques after implantation may provide valuable information. These osteoinductive bone substitutes may be satisfactorily used in future as an alternative to autologous or allogenous bone grafts.
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D.F. Williams. The Williams dictionary of biomaterials. Liverpool University Press (1999)
F.C.M. Driessens. Monographs in oral science. Vol. 10. Basel, Karger(1982)
K. De Groot. Bioceramics of calcium phosphate. CRC Press Inc.; Boca Raton, Florida (1983)
R.Z. Legeros. Calcium phosphates in oral biology and medicine. Monographs in Oral Science. Vol. 15. Basel, Karger (1991)
J.C. Elliot. Structures and Chemistry of the Apatites and Other Calcium Orthophosphates. Studies in Inorganic Chemistry 18. Elsevier; Amsterdam (1994)
L.C. Chow, E.D. Eanes. Octacalcium phosphate. Karger, Basel (2001)
W.E. Brown, Nature 196 (1962) 1048
G. Daculsi, R.Z. Legeros, B. Nery, K. Lynch and B. Kerebel. J. Biomed. Mater. Res. 23 (1983) 883
G. Daculsi, R.Z. Legeros. M. Heughebaert and Barbieux I. Calcif. Tissue Int. 46 (1990) 20
G. Daculsi and N. Passuti. Biomaterials. 11 (1990) 86
G. Daculsi, N. Passuti, S. Martin, C. Deudon. R.Z. Legeros and S. Raher. J. Biomed. Mater. Res. 24 (1990) 379
N. Passuti, G. Daculsi, J.M. Rogez, S. Martin and J.V. Bainvel. Clin. Orthop. Relat. Res. 248 (1989) 169
G. Daculsi, O. Laboux, O. Malard and P. Weiss. J. Mater. Sci., Mater. Med. 14 (2003) 95
B.R. Constantz, et al. Science 267 (1995) 1796.
L. Le Guehennec, E. Goyenvalle, E. Aguado, M. Houchmand-Cuny, B. Enkel, P. Pilet, G. Daculsi and P. Layrolle. J. Biomed. Mater. Res. Appl. Biomater. 72B (2005) 69
P. Layrolle and A. Lebugle. Chem. Mater. 6 (1994) 1996
Y. Osaka, Y. Miura, K. Takeuchi, M. Asada and K. Takahashi. J. Mater. Sci., Mater. Med. 2 (1991) 51
J.C. Heughebaert and G. Montel. Calcif. Tissue Int. 34 (1982) 103
P. Layrolle, A. Ito and T. Tateishi. J. Am. Ceram. Soc. 81 (1998) 1421
E.D. Eanes, I.H. Gillesen and A.S. Posner. Nature 208 (1965) 365
A.S. Posner and F. Betts. Acc. Chem. Res. 8 (1975) 273
G. Treboux, P. Layrolle, N. Kanzaki, K. Onuma and A. Ito. J. Phys. Chem. A 104 (2000) 5111
G. Treboux, P. Layrolle, N. Kanzaki, K. Onuma and A. Ito . J. Am. Chem. Soc. 122 (2000) 8323
N. Kanzaki, G. Treboux, K. Onuma and A. Ito. Biomaterials 22 (2001) 2921
H. Yamasaki and H. Sakai. Biomaterials. 13 (1992) 308.
S.H. Li, J.R. De Wijn, P. Layrolle and K. De Groot. J. Biomed. Mater. Res. 61 (2002) 109
S.H. Li, J. De Wijn, P. Layrolle and K. De Groot .J. Am. Ceram. Soc. 86 (2003) 65
U. Ripamonti. Biomaterials 17 (1996) 31
C. Klein, K. De Groot, W. Chen, Y. Li and X. Zhang. Biomaterials 15 (1994) 31
Z. Yang, H. Yuan, W. Tong, P. Zou, W. Chen and X. Zhang. Biomaterials 17 (1996) 2131
H. Yuan, Z. Yang, Y. Li, X. Zhang, J.D. De Bruijn and K. De Groot. J. Mater. Sci.: Mater. Med. 9 (1998) 723
H. Yuan, Z. Yang, J.D. De Bruijn, K. De Groot and X. Zhang. Biomaterials. 22 (2001) 2617
H. Yuan, M. Van Den Doel, S. Li, C.A. Van Blitterswijk, K. De Groot and J.D. De Bruijn. J. Mater. Sci. Mater. Med. 13 (2002) 127
P. Habibovic, J. Li, C.M. Van Der Valk, G. Meijer, P. Layrolle, C.A. Van Blitterswijk and K. De Groot. Biomaterials 26 (2005) 23.
D. Le Nihouannen, G. Daculsi, A. Saffarzadeh, O. Gauthier, S. Delplace, P. Pilet and P. Layrolle. Bone 36 (2005) 1086
K. De Groot. Tissue Eng. 4 (1998) 337
L. Diaz-Flores, R. Gutierrez A. Lopez-Alonso, R. Gonzalez and H. Varela. Clin. Orthop. 275 (1992) 280
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The authors acknowledge the company Biomatlante for providing biphasic calcium phosphate (MBCP™).
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Layrolle, P., Daculsi, G. (2009). Physicochemistry of Apatite and Its Related Calcium Phosphates. In: León, B., Jansen, J. (eds) Thin Calcium Phosphate Coatings for Medical Implants. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77718-4_2
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