Advertisement

Biomimetic Coatings and Their Biological Functionalization

  • Yuelian Liu
  • Ernst B. Hunziker
Chapter

Abstract

The biomimetic coating technique can be used to deposit layers of calcium phosphate (CaP) on medical devices to improve their osteoconductivity and osseointegration.The inorganic layer generated is akin to mineralized bone matrix and can be degraded as such. The biomimetic coating technique involves the nucleation and growth of bone-like crystals on a pretreated substrate by immersing it in a supersaturated solution of CaP under physiological conditions of temperature (37°C) and pH (7.4). The method, originally developed by Kokubo and his co-workers in 1990, has since undergone improvement and refinement by several groups of investigators. Biomimetic coatings are valuable in that they can serve as a vehicle for the slow, sustained release of osteogenic agents at the site of implantation. This attribute is rendered possible by the near-physiological conditions under which these coatings are prepared, which permits the incorporation of bioactive agents into the inorganic crystal latticework rather than their superficial adsorption on preformed layers. In addition, the biomimetic coating technique can be applied to implants of an organic as well as of a metallic nature and to those with irregular surface geometries, which is not possible using conventional methodologies.

Keywords

Ectopic Bone Formation Bioactive Agent Osteogenic Effect Coated Implant Biological Milieu 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    K. De Groot, J Oral Implantol 12 (1986) 485.Google Scholar
  2. 2.
    K. De Groot, J Biomed Mater Res 23 (1989) 1367.CrossRefGoogle Scholar
  3. 3.
    T. Kitsugi, T. Yamamuro, T. Nakamura, S. Kotani, T. Kokubo and H. Takeuchi, Biomaterials 14 (1993) 216.CrossRefGoogle Scholar
  4. 4.
    C. P. Klein, A. A. Driessen and K. De Groot, Biomaterials 5 (1984) 157.CrossRefGoogle Scholar
  5. 5.
    C. P. Klein, J. G. Wolke, J. M. De Blieck-Hogervorst and K. De Groot, J Biomed Mater Res 28 (1994a) 961.Google Scholar
  6. 6.
    C. P. Klein, P. Patka, J. G. Wolke, J. M. De Blieck-Hogervorst and K. De Groot, Biomaterials 15 (1994c) 146.Google Scholar
  7. 7.
    H. Zhang, S. Li, Y. Yan and Y. Wang, Biomed Mater Eng 10 (2000) 213.Google Scholar
  8. 8.
    H. Schliephake, D. Scharnweber, M. Dard, S. Robetaler, A. Sewing and C. Huttmann, J Biomed Mater Res 64A (2003) 225.CrossRefGoogle Scholar
  9. 9.
    K. De Groot, R. Geesink, C. P. Klein and P. Serekian, J Biomed Mater Res 21 (1987) 1375.CrossRefGoogle Scholar
  10. 10.
    J. G. Wolke, K. Van Dijk, H. G. Schaeken, K. De Groot and J. A. Jansen, J Biomed Mater Res 28 (1994) 1477.CrossRefGoogle Scholar
  11. 11.
    J. G. Wolke, J. P. Van Der Waerden, K. De Groot and J. A. Jansen, Biomaterials 18 (1997) 483.CrossRefGoogle Scholar
  12. 12.
    J. G. Wolke, K. DE Groot and J. A. Jansen, J Biomed Mater Res 39 (1998a) 524.Google Scholar
  13. 13.
    J. G. Wolke, K. De Groot and J. A. Jansen, J Biomed Mater Res 43 (1998b) 270.Google Scholar
  14. 14.
    J. A. Jansen, J. G. Wolke, S. Swann, J. P. van der Waerden and K. De Groot, Clin Oral Implants Res 4 (1993) 28.CrossRefGoogle Scholar
  15. 15.
    J. W. Vehof, J. Van Den Dolder, J. E. De Ruijter, P. H. Spauwen and J. A. Jansen, J Biomed Mater Res 64A (2003) 417.CrossRefGoogle Scholar
  16. 16.
    L. Agata De Sena, M. Calixto De Andrade, A. Malta Rossi and G. DE Almeida Soares, J Biomed Mater Res 60 (2002) 1.CrossRefGoogle Scholar
  17. 17.
    J. Wang, J. De Boer and K. De Groot, J Dent Res 83 (2004) 296.CrossRefGoogle Scholar
  18. 18.
    J. Wang, P. Layrolle, M. Stigter and K. De Groot, Biomaterials 25 (2004) 583.CrossRefGoogle Scholar
  19. 19.
    T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi and T. Yamamuro, J Biomed Mater Res 24 (1990) 721.CrossRefGoogle Scholar
  20. 20.
    T. Kokubo, Biomaterials 12 (1991) 155.CrossRefGoogle Scholar
  21. 21.
    P. Li, (US Patent 6139583) (2000).Google Scholar
  22. 22.
    H. B. Wen, J. R. De Wijn, C. A. van Blitterswijk and K. De Groot, J Biomed Mater Res 46 (1999) 245.CrossRefGoogle Scholar
  23. 23.
    Y. Liu, P. Layrolle, J. De Bruijn, C. Van Blitterswijk and K. De Groot, J Biomed Mater Res 57 (2001) 327.CrossRefGoogle Scholar
  24. 24.
    Y. Liu, E. B. Hunziker, P. Layrolle, C. van Blitterswijk, P. D. Calvert and K. De Groot, J Biomed Mater Res A 67 (2003d) 1155.Google Scholar
  25. 25.
    K. De Groot, J. G. Wolke and J. A. Jansen, Proc Inst Mech Eng [H] 212 (1998) 137.Google Scholar
  26. 26.
    F. Barrere, C. A. van Blitterswijk, K. De Groot and P. Layrolle, Biomaterials 23 (2002a) 1921.Google Scholar
  27. 27.
    F. Barrere, B. C. Van, G. K. De and P. Layrolle, Biomaterials 23 (2002b) 2211.Google Scholar
  28. 28.
    F. Barrere, P. Layrolle, C. A. van Blitterswijk and K. De Groot, J Mater Sci Mater Med 12 (2001) 529.CrossRefGoogle Scholar
  29. 29.
    F. Barrere, P. Layrolle, C. A. van Blitterswijk and K. De Groot, Bone 25 (1999) 107S.CrossRefGoogle Scholar
  30. 30.
    B. Gondolph-Zink, Orthopade 27 (1998) 96.Google Scholar
  31. 31.
    P. J. F. Layrolle, K. De Groot, J. D. De Bruijn, C. A. Van Blitterswijk and H. Huipin, (US Patent 6207218) (2001).Google Scholar
  32. 32.
    P. Li and P. Ducheyne, J Biomed Mater Res 41 (1998) 341.CrossRefGoogle Scholar
  33. 33.
    I. Ono, H. Gunji, F. Kaneko, T. Saito and Y. Kuboki, J Craniofac Surg 6 (1995) 238.CrossRefGoogle Scholar
  34. 34.
    J. P. Fiorellini, D. Buser, E. Riley and T. H. Howell, Int J Periodontics Restorative Dent 21 (2001) 41.Google Scholar
  35. 35.
    T. Kawai, A. Mieki, Y. Ohno, M. Umemura, H. Kataoka, S. Kurita, M. Koie, T. Jinde, J. Hasegawa and M. R. Urist, Clin Orthop (1993) 296.Google Scholar
  36. 36.
    A. H. Reddi and N. S. Cunningham, Biomaterials 11 (1990) 33.Google Scholar
  37. 37.
    C. M. Agrawal, J. Best, J. D. Heckman and B. D. Boyan, Biomaterials 16 (1995) 1255.CrossRefGoogle Scholar
  38. 38.
    I. Ono, H. Gunji, K. Suda, F. Kaneko, M. Murata, T. Saito and Y. Kuboki, Plast Reconstr Surg 95 (1995) 1265.CrossRefGoogle Scholar
  39. 39.
    S. A. Esenwein, S. Esenwein, G. Herr, G. Muhr, W. Kusswetter and C. H. Hartwig, Chirurg 72 (2001) 1360.CrossRefGoogle Scholar
  40. 40.
    X. Wang, Y. Jin, B. Liu, S. Zhou, L. Yang, X. Yang and F. H. White, Int J Oral Maxillofac Surg 23 (1994) 115.CrossRefGoogle Scholar
  41. 41.
    K. Endo, Dent Mater J 14 (1995) 185.CrossRefGoogle Scholar
  42. 42.
    H. M. Kim, F. Miyaji, T. Kokubo and T. Nakamura, J Biomed Mater Res 32 (1996) 409.CrossRefGoogle Scholar
  43. 43.
    M. R. Urist, Science 150 (1965) 893.CrossRefGoogle Scholar
  44. 44.
    G. Aldinger, G. Herr, W. Kusswetter, H. J. Reis, F. W. Thielemann and U. Holz, Int Orthop 15 (1991) 169.CrossRefGoogle Scholar
  45. 45.
    K. Elima, Ann Med 25 (1993) 395.CrossRefGoogle Scholar
  46. 46.
    M. B. Lee, J Clin Periodontol 24 (1997) 355.CrossRefGoogle Scholar
  47. 47.
    K. Takahashi, Nippon Yakurigaku Zasshi 116 (2000) 232.CrossRefGoogle Scholar
  48. 48.
    R. T. Franceschi, Crit Rev Oral Biol Med 10 (1999) 40.CrossRefGoogle Scholar
  49. 49.
    A. Yamaguchi, Nippon Rinsho 60 Suppl 3 (2002) 40.Google Scholar
  50. 50.
    A. H. Reddi, Clin Orthop (1998) S66.Google Scholar
  51. 51.
    D. D. Lee, A. Tofighi, M. Aiolova, P. Chakravarthy, A. Catalano, A. Majahad and D. Knaack, Clin Orthop (1999) S396.Google Scholar
  52. 52.
    G. Schmidmaier, B. Wildemann, F. Cromme, F. Kandziora, N. P. Haas and M. Raschke, Bone 30 (2002) 816.CrossRefGoogle Scholar
  53. 53.
    L. A. Salata, V. Franke-Stenport AND L. Rasmusson, Clin Implant Dent Relat Res 4 (2002) 27.CrossRefGoogle Scholar
  54. 54.
    J. O. Hollinger AND K. Leong, Biomaterials 17 (1996) 187.CrossRefGoogle Scholar
  55. 55.
    G. N. KING, Curr Pharm Biotechnol 2 (2001) 131.CrossRefGoogle Scholar
  56. 56.
    C. A. Kirker-Head, Adv Drug Deliv Rev 43 (2000) 65.CrossRefGoogle Scholar
  57. 57.
    Y. Liu, E. B. Hunziker, C. Van De Vaal and K. De Groot, Key Engineering Materials, Trans Tech Publications 254-256 (2004) 619.Google Scholar
  58. 58.
    Y. Liu, E. B. Hunziker, P. Layrolle, J. D. De Bruijn and K. De Groot, Tissue Eng 10 (2004) 101.CrossRefGoogle Scholar
  59. 59.
    Y. Liu, E. B. Hunziker, K. De Groot and P. Layrolle, in Bioceramics 15, edited by B. Ben-Nissan, D. Sher and W. Walsh (Trans Tech Publications, Sydney, 2002) p. 667.Google Scholar
  60. 60.
    D. A. Oakes and J. R. Lieberman, Clin Orthop (2000) S101.Google Scholar
  61. 61.
    H. Ohgushi and A. I. Caplan, J Biomed Mater Res 48 (1999) 913.CrossRefGoogle Scholar
  62. 62.
    A. A. Scaduto and J. R. Lieberman, Orthop Clin North Am 30 (1999) 625.CrossRefGoogle Scholar
  63. 63.
    T. D. Alden, P. Varady, D. F. Kallmes, J. A. Jane, JR. and G. A. Helm, Spine 27 (2002) S87.CrossRefGoogle Scholar
  64. 64.
    W. Becker and B. E. Becker, J Am Dent Assoc 124 (1993) 37.Google Scholar
  65. 65.
    M. Shirkhanzadeh and G. Q. Liu, Materials Lett 21 (1994) 115.CrossRefGoogle Scholar
  66. 66.
    A. G. Coombes and J. D. Heckman, Biomaterials 13 (1992) 217.CrossRefGoogle Scholar
  67. 67.
    Y. Liu, K. De Groot and E. B. Hunziker, Bone 36 (2005) 745.CrossRefGoogle Scholar
  68. 68.
    Y. Liu, L. Enggist, A. F. Kuffer, D. Buser and E. B. Hunziker, Biomaterials 28 (2007) 2677.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Section of Oral Implantology, Department of Oral FunctionAcademic Centre of Dentistry Amsterdam (ACTA)The Netherlands
  2. 2.ITI Research Institute for Dental and Skeletal BiologyUniversity of BernSwitzerland

Personalised recommendations