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Supercritical Fluid Technology for Nanotechnology in Drug Delivery

  • Mohammed J. Meziani
  • Pankaj Pathak
  • Ya-Ping Sun
Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume X)

Introduction

In the past few decades, supercritical fluid technology has attracted the attention of both scientists and engineers (McHugh and Krukonis, 1994; Taylor, 1996; Brennecke, 1993; Hutchenson and Foster, 1995; Levelt Sengers, 1991; Kendall et al., 1999). Early studies on the application of supercritical fluid technology were primarily in extraction and chromatography. Extensive experimental and theoretical investigations have been aimed toward an understanding of the properties of supercritical fluid systems, particularly intermolecular interactions (solute–solvent, solvent–solvent, and solute–solute) in supercritical fluid solutions (Tucker, 1999; Jessop and Leitner, 1999; Sun, 2002). Much progress has also been made in the use of supercritical fluids and mixtures as reaction media for chemical synthesis and as alternative solvent systems for materials processing (Sun, 2002; Poliakoff et al., 1996; Kajimoto, 1999; Savage, 1999; Musie et al., 2001). Recently, several...

Keywords

Supercritical Fluid Fluticasone Propionate Drug Particle Stabilization Agent Salmeterol Xinafoate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

Financial support from NSF and the Center for Advanced Engineering Fibers and Films (NSF-ERC at Clemson University) is gratefully acknowledged.

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Mohammed J. Meziani
    • 1
  • Pankaj Pathak
  • Ya-Ping Sun
  1. 1.Department of Chemistry and Laboratory for Emerging Materials and TechnologyClemson UniversityClemsonUSA

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